MYC2_ORYSJ
ID MYC2_ORYSJ Reviewed; 699 AA.
AC Q336P5; A0A0P0XY34; Q6QJB9; Q9AYK0;
DT 09-DEC-2015, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Transcription factor MYC2 {ECO:0000305};
DE Short=OsMYC2 {ECO:0000303|PubMed:24647160};
DE AltName: Full=Basic helix-loop-helix protein 9 {ECO:0000303|PubMed:16896230};
DE Short=OsbHLH009 {ECO:0000303|PubMed:16896230};
DE Short=bHLH 9 {ECO:0000305};
GN Name=MYC2 {ECO:0000303|PubMed:24647160}; Synonyms=BHLH9 {ECO:0000305};
GN OrderedLocusNames=Os10g0575000 {ECO:0000312|EMBL:BAF27315.1},
GN LOC_Os10g42430 {ECO:0000312|EMBL:ABB48017.1};
GN ORFNames=OSJNBa0003O19.20 {ECO:0000312|EMBL:AAK00453.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhu Z.;
RT "Oryza sativa MYC protein mRNA, complete cds.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=12791992; DOI=10.1126/science.1083523;
RA Yu Y., Rambo T., Currie J., Saski C., Kim H.-R., Collura K., Thompson S.,
RA Simmons J., Yang T.-J., Nah G., Patel A.J., Thurmond S., Henry D.,
RA Oates R., Palmer M., Pries G., Gibson J., Anderson H., Paradkar M.,
RA Crane L., Dale J., Carver M.B., Wood T., Frisch D., Engler F.,
RA Soderlund C., Palmer L.E., Teytelman L., Nascimento L., De la Bastide M.,
RA Spiegel L., Ware D., O'Shaughnessy A., Dike S., Dedhia N., Preston R.,
RA Huang E., Ferraro K., Kuit K., Miller B., Zutavern T., Katzenberger F.,
RA Muller S., Balija V., Martienssen R.A., Stein L., Minx P., Johnson D.,
RA Cordum H., Mardis E., Cheng Z., Jiang J., Wilson R., McCombie W.R.,
RA Wing R.A., Yuan Q., Ouyang S., Liu J., Jones K.M., Gansberger K.,
RA Moffat K., Hill J., Tsitrin T., Overton L., Bera J., Kim M., Jin S.,
RA Tallon L., Ciecko A., Pai G., Van Aken S., Utterback T., Reidmuller S.,
RA Bormann J., Feldblyum T., Hsiao J., Zismann V., Blunt S., de Vazeille A.R.,
RA Shaffer T., Koo H., Suh B., Yang Q., Haas B., Peterson J., Pertea M.,
RA Volfovsky N., Wortman J., White O., Salzberg S.L., Fraser C.M., Buell C.R.,
RA Messing J., Song R., Fuks G., Llaca V., Kovchak S., Young S., Bowers J.E.,
RA Paterson A.H., Johns M.A., Mao L., Pan H., Dean R.A.;
RT "In-depth view of structure, activity, and evolution of rice chromosome
RT 10.";
RL Science 300:1566-1569(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16896230; DOI=10.1104/pp.106.080580;
RA Li X., Duan X., Jiang H., Sun Y., Tang Y., Yuan Z., Guo J., Liang W.,
RA Chen L., Yin J., Ma H., Wang J., Zhang D.;
RT "Genome-wide analysis of basic/helix-loop-helix transcription factor family
RT in rice and Arabidopsis.";
RL Plant Physiol. 141:1167-1184(2006).
RN [7]
RP FUNCTION, INTERACTION WITH TIFY3/JAZ1, AND TISSUE SPECIFICITY.
RX PubMed=24647160; DOI=10.1038/ncomms4476;
RA Cai Q., Yuan Z., Chen M., Yin C., Luo Z., Zhao X., Liang W., Hu J.,
RA Zhang D.;
RT "Jasmonic acid regulates spikelet development in rice.";
RL Nat. Commun. 5:3476-3476(2014).
CC -!- FUNCTION: Transcriptional activator involved in jasmonate (JA)
CC signaling pathway during spikelet development. Binds to the G2 region
CC G-box (5'-CACGTG-3') of the MADS1 promoter and thus directly regulates
CC the expression of MADS1. Its function in MADS1 activation is abolished
CC by TIFY3/JAZ1 which directly target MYC2 during spikelet development.
CC {ECO:0000269|PubMed:24647160}.
CC -!- SUBUNIT: Interacts with TIFY3/JAZ1. {ECO:0000269|PubMed:24647160}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Highly expressed in spikelets and floral organs.
CC {ECO:0000269|PubMed:24647160}.
CC -!- SIMILARITY: Belongs to the bHLH protein family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK00453.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY536428; AAS66204.1; -; mRNA.
DR EMBL; AC060755; AAK00453.1; ALT_INIT; Genomic_DNA.
DR EMBL; DP000086; ABB48017.1; -; Genomic_DNA.
DR EMBL; AP008216; BAF27315.1; -; Genomic_DNA.
DR EMBL; AP014966; BAT12190.1; -; Genomic_DNA.
DR RefSeq; XP_015614012.1; XM_015758526.1.
DR AlphaFoldDB; Q336P5; -.
DR SMR; Q336P5; -.
DR STRING; 4530.OS10T0575000-01; -.
DR PaxDb; Q336P5; -.
DR PRIDE; Q336P5; -.
DR EnsemblPlants; Os10t0575000-01; Os10t0575000-01; Os10g0575000.
DR GeneID; 4349484; -.
DR Gramene; Os10t0575000-01; Os10t0575000-01; Os10g0575000.
DR KEGG; osa:4349484; -.
DR eggNOG; ENOG502QUFW; Eukaryota.
DR HOGENOM; CLU_021132_0_1_1; -.
DR InParanoid; Q336P5; -.
DR OMA; AYGNENN; -.
DR OrthoDB; 371763at2759; -.
DR PlantReactome; R-OSA-6787011; Jasmonic acid signaling.
DR Proteomes; UP000000763; Chromosome 10.
DR Proteomes; UP000059680; Chromosome 10.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR045084; AIB/MYC-like.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR025610; MYC/MYB_N.
DR PANTHER; PTHR11514; PTHR11514; 1.
DR Pfam; PF14215; bHLH-MYC_N; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Jasmonic acid signaling pathway; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..699
FT /note="Transcription factor MYC2"
FT /id="PRO_0000434865"
FT DOMAIN 520..569
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 25..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..158
FT /note="JAZ-interaction domain"
FT /evidence="ECO:0000250|UniProtKB:Q39204"
FT REGION 290..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..533
FT /note="Basic motif; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 534..569
FT /note="Helix-loop-helix motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 582..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 506..514
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 27..42
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..353
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 584..598
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 699 AA; 75104 MW; 56FD71EFF7A1BEC1 CRC64;
MNLWTDDNAS MMEAFMASAD LPAFPWGAAS TPPPPPPPPH HHHQQQQQQV LPPPAAAPAA
AAFNQDTLQQ RLQSIIEGSR ETWTYAIFWQ SSIDVSTGAS LLGWGDGYYK GCDDDKRKQR
SSTPAAAAEQ EHRKRVLREL NSLIAGAGAA PDEAVEEEVT DTEWFFLVSM TQSFPNGLGL
PGQALFAAQP TWIATGLSSA PCDRARQAYT FGLRTMVCLP LATGVLELGS TDVIFQTGDS
IPRIRALFNL SAAAASSWPP HPDAASADPS VLWLADAPPM DMKDSISAAD ISVSKPPPPP
PHQIQHFENG STSTLTENPS PSVHAPTPSQ PAAPPQRQQQ QQQSSQAQQG PFRRELNFSD
FASNGGAAAP PFFKPETGEI LNFGNDSSSG RRNPSPAPPA ATASLTTAPG SLFSQHTPTL
TAAANDAKSN NQKRSMEATS RASNTNNHPA ATANEGMLSF SSAPTTRPST GTGAPAKSES
DHSDLEASVR EVESSRVVAP PPEAEKRPRK RGRKPANGRE EPLNHVEAER QRREKLNQRF
YALRAVVPNV SKMDKASLLG DAISYINELR GKLTALETDK ETLQSQMESL KKERDARPPA
PSGGGGDGGA RCHAVEIEAK ILGLEAMIRV QCHKRNHPAA RLMTALRELD LDVYHASVSV
VKDLMIQQVA VKMASRVYSQ DQLNAALYTR IAEPGTAAR
