MYCBP_MOUSE
ID MYCBP_MOUSE Reviewed; 103 AA.
AC Q9EQS3; O88308; Q8R048;
DT 11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 5.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=c-Myc-binding protein;
DE AltName: Full=Associate of Myc 1;
DE Short=AMY-1;
GN Name=Mycbp; Synonyms=Amy1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND INDUCTION.
RC STRAIN=129/SvEvTacfBr; TISSUE=Spleen, and Thymus;
RX PubMed=12620400; DOI=10.1016/s0888-7543(03)00006-5;
RA Furusawa M., Taira T., Iguchi-Ariga S.M.M., Ariga H.;
RT "Molecular cloning of the mouse AMY-1 gene and identification of the
RT synergistic activation of the AMY-1 promoter by GATA-1 and Sp1.";
RL Genomics 81:221-233(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, Pancreas, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May control the transcriptional activity of MYC. Stimulates
CC the activation of E box-dependent transcription by MYC (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Binds via its C-terminal region to the N-terminal region of
CC MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP. Interacts
CC with CFAP91. {ECO:0000250|UniProtKB:Q99417}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC Note=Translocates into the nucleus in the S phase of the cell cycle.
CC {ECO:0000250}.
CC -!- INDUCTION: MYCBP expression is synergistically activated by SP1 and
CC GATA-1. {ECO:0000269|PubMed:12620400}.
CC -!- SIMILARITY: Belongs to the AMY1 family. {ECO:0000305}.
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DR EMBL; AB015858; BAA31257.1; -; mRNA.
DR EMBL; AB052913; BAB20018.1; -; Genomic_DNA.
DR EMBL; AK077633; BAC36916.1; -; mRNA.
DR EMBL; AK077762; BAC36997.1; -; mRNA.
DR EMBL; AK037661; BAE20517.1; -; mRNA.
DR EMBL; AK145773; BAE26643.1; -; mRNA.
DR EMBL; AL606962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466552; EDL30369.1; -; Genomic_DNA.
DR EMBL; BC028344; AAH28344.1; -; mRNA.
DR EMBL; BC048478; AAH48478.1; -; mRNA.
DR CCDS; CCDS18621.1; -.
DR RefSeq; NP_062634.2; NM_019660.3.
DR AlphaFoldDB; Q9EQS3; -.
DR SMR; Q9EQS3; -.
DR BioGRID; 207892; 9.
DR CORUM; Q9EQS3; -.
DR IntAct; Q9EQS3; 1.
DR STRING; 10090.ENSMUSP00000030400; -.
DR iPTMnet; Q9EQS3; -.
DR PhosphoSitePlus; Q9EQS3; -.
DR EPD; Q9EQS3; -.
DR jPOST; Q9EQS3; -.
DR MaxQB; Q9EQS3; -.
DR PaxDb; Q9EQS3; -.
DR PeptideAtlas; Q9EQS3; -.
DR PRIDE; Q9EQS3; -.
DR ProteomicsDB; 286093; -.
DR DNASU; 56309; -.
DR Ensembl; ENSMUST00000030400; ENSMUSP00000030400; ENSMUSG00000028647.
DR GeneID; 56309; -.
DR KEGG; mmu:56309; -.
DR UCSC; uc008uql.1; mouse.
DR CTD; 26292; -.
DR MGI; MGI:1891750; Mycbp.
DR VEuPathDB; HostDB:ENSMUSG00000028647; -.
DR eggNOG; ENOG502S2IC; Eukaryota.
DR GeneTree; ENSGT00390000017974; -.
DR HOGENOM; CLU_135895_0_1_1; -.
DR InParanoid; Q9EQS3; -.
DR OMA; QYEPLQE; -.
DR OrthoDB; 1497203at2759; -.
DR TreeFam; TF329224; -.
DR BioGRID-ORCS; 56309; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Mycbp; mouse.
DR PRO; PR:Q9EQS3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q9EQS3; protein.
DR Bgee; ENSMUSG00000028647; Expressed in undifferentiated genital tubercle and 244 other tissues.
DR ExpressionAtlas; Q9EQS3; baseline and differential.
DR Genevisible; Q9EQS3; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005739; C:mitochondrion; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR InterPro; IPR026060; AMY1.
DR PANTHER; PTHR13168; PTHR13168; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..103
FT /note="c-Myc-binding protein"
FT /id="PRO_0000220981"
FT CONFLICT 11
FT /note="R -> H (in Ref. 1; BAB20018)"
FT /evidence="ECO:0000305"
FT CONFLICT 65
FT /note="L -> V (in Ref. 1; BAA31257)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 103 AA; 11970 MW; 7B9D901788F912D0 CRC64;
MAHYKAADSK REQFRRYLEK SGVLDTLTKV LVALYEEPEK PTSALDFLKH HLGAATPENP
EIELLRLELA EMKEKYEATV EENKKLKAKL VQYEPPQEEK RAE
