MYCB_MOUSE
ID MYCB_MOUSE Reviewed; 170 AA.
AC Q6P8Z1; Q9D6E3;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein B-Myc;
GN Name=Mycb; Synonyms=Bmyc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Hippocampus, and Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF SER-60 AND SER-68,
RP PHOSPHORYLATION AT SER-60 AND SER-68, AND TISSUE SPECIFICITY.
RX PubMed=11039906; DOI=10.1038/sj.onc.1203851;
RA Gregory M.A., Xiao Q., Cornwall G.A., Lutterbach B., Hann S.R.;
RT "B-Myc is preferentially expressed in hormonally-controlled tissues and
RT inhibits cellular proliferation.";
RL Oncogene 19:4886-4895(2000).
CC -!- FUNCTION: Seems to act as an inhibitor of cellular proliferation.
CC {ECO:0000269|PubMed:11039906}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11039906}.
CC -!- TISSUE SPECIFICITY: Highly expressed in epididymis. Also expressed in
CC hypothalamus, pituitary, uterus and ovary. Low expression in testis.
CC Not detected in heart. {ECO:0000269|PubMed:11039906}.
CC -!- PTM: Rapidly degraded via the ubiquitin-proteasome pathway.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB28992.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK012810; BAE43234.1; -; mRNA.
DR EMBL; AK013780; BAB28992.1; ALT_FRAME; mRNA.
DR EMBL; AK158603; BAE34577.1; -; mRNA.
DR EMBL; BC061001; AAH61001.1; -; mRNA.
DR CCDS; CCDS15789.1; -.
DR RefSeq; NP_075815.2; NM_023326.2.
DR AlphaFoldDB; Q6P8Z1; -.
DR IntAct; Q6P8Z1; 3.
DR MINT; Q6P8Z1; -.
DR STRING; 10090.ENSMUSP00000097885; -.
DR iPTMnet; Q6P8Z1; -.
DR PhosphoSitePlus; Q6P8Z1; -.
DR PaxDb; Q6P8Z1; -.
DR PRIDE; Q6P8Z1; -.
DR ProteomicsDB; 287561; -.
DR DNASU; 107771; -.
DR Ensembl; ENSMUST00000061483; ENSMUSP00000097885; ENSMUSG00000049086.
DR GeneID; 107771; -.
DR KEGG; mmu:107771; -.
DR UCSC; uc008itg.1; mouse.
DR CTD; 107771; -.
DR MGI; MGI:88184; Bmyc.
DR VEuPathDB; HostDB:ENSMUSG00000049086; -.
DR eggNOG; KOG2483; Eukaryota.
DR GeneTree; ENSGT00940000155285; -.
DR HOGENOM; CLU_135109_0_0_1; -.
DR InParanoid; Q6P8Z1; -.
DR OMA; PDCTCNT; -.
DR OrthoDB; 877891at2759; -.
DR PhylomeDB; Q6P8Z1; -.
DR BioGRID-ORCS; 107771; 1 hit in 76 CRISPR screens.
DR ChiTaRS; Bmyc; mouse.
DR PRO; PR:Q6P8Z1; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q6P8Z1; protein.
DR Bgee; ENSMUSG00000049086; Expressed in embryonic brain and 215 other tissues.
DR ExpressionAtlas; Q6P8Z1; baseline and differential.
DR Genevisible; Q6P8Z1; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR DisProt; DP00564; -.
DR InterPro; IPR002418; Tscrpt_reg_Myc.
DR InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR Pfam; PF01056; Myc_N; 1.
DR PRINTS; PR00044; LEUZIPPRMYC.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..170
FT /note="Protein B-Myc"
FT /id="PRO_0000127339"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:11039906"
FT MOD_RES 68
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:11039906"
FT MUTAGEN 60
FT /note="S->A: Loss of phosphorylation."
FT /evidence="ECO:0000269|PubMed:11039906"
FT MUTAGEN 68
FT /note="S->A: Loss of phosphorylation."
FT /evidence="ECO:0000269|PubMed:11039906"
SQ SEQUENCE 170 AA; 18526 MW; EF3BD10DD793C2D4 CRC64;
MPLHVSLANG NRDLDYDSVQ PYFMCDDEEE DVHHQQPPQP PAPSEDIWKK FELLPTPRPS
PGHAGLYSPP CEAVAVSFAP RDHDGDSFSI ADLPELPGGD AVKQSFVCDP DDETFVKNII
LQDCMWNGFS ASAKLVSKLD PYQAVRKEGT GVSLAADVEP ATPPDCTCNT
