ID   MYCL_MOUSE              Reviewed;         368 AA.
AC   P10166; Q5FWI7;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 165.
DE   RecName: Full=Protein L-Myc;
GN   Name=Mycl; Synonyms=Lmyc1, Mycl1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BALB/cJ;
RX   PubMed=2828024; DOI=10.1002/j.1460-2075.1987.tb02657.x;
RA   Legouy E., DePinho R.A., Zimmerman K., Collum R., Yancopoulos G.D.,
RA   Mitsock L., Kriz R., Alt F.W.;
RT   "Structure and expression of the murine L-myc gene.";
RL   EMBO J. 6:3359-3366(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Binds DNA as a heterodimer with MAX.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; X13945; CAA32128.1; -; Genomic_DNA.
DR   EMBL; BC053059; AAH53059.1; -; mRNA.
DR   EMBL; BC089346; AAH89346.1; -; mRNA.
DR   CCDS; CCDS18606.1; -.
DR   PIR; S03017; TVMSML.
DR   RefSeq; NP_001290050.1; NM_001303121.1.
DR   RefSeq; NP_032532.1; NM_008506.3.
DR   RefSeq; XP_006502884.1; XM_006502821.3.
DR   AlphaFoldDB; P10166; -.
DR   SMR; P10166; -.
DR   BioGRID; 201184; 1.
DR   IntAct; P10166; 1.
DR   STRING; 10090.ENSMUSP00000030407; -.
DR   iPTMnet; P10166; -.
DR   PhosphoSitePlus; P10166; -.
DR   PaxDb; P10166; -.
DR   PeptideAtlas; P10166; -.
DR   PRIDE; P10166; -.
DR   Antibodypedia; 17920; 144 antibodies from 27 providers.
DR   DNASU; 16918; -.
DR   Ensembl; ENSMUST00000030407; ENSMUSP00000030407; ENSMUSG00000028654.
DR   Ensembl; ENSMUST00000106252; ENSMUSP00000101859; ENSMUSG00000028654.
DR   GeneID; 16918; -.
DR   KEGG; mmu:16918; -.
DR   UCSC; uc008uop.2; mouse.
DR   CTD; 4610; -.
DR   MGI; MGI:96799; Mycl.
DR   VEuPathDB; HostDB:ENSMUSG00000028654; -.
DR   eggNOG; ENOG502QWSU; Eukaryota.
DR   GeneTree; ENSGT00940000158613; -.
DR   HOGENOM; CLU_052560_0_0_1; -.
DR   InParanoid; P10166; -.
DR   OMA; CHPRPVS; -.
DR   OrthoDB; 877891at2759; -.
DR   PhylomeDB; P10166; -.
DR   TreeFam; TF106001; -.
DR   BioGRID-ORCS; 16918; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Mycl; mouse.
DR   PRO; PR:P10166; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; P10166; protein.
DR   Bgee; ENSMUSG00000028654; Expressed in urinary bladder urothelium and 234 other tissues.
DR   ExpressionAtlas; P10166; baseline and differential.
DR   Genevisible; P10166; MM.
DR   GO; GO:0005694; C:chromosome; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0045607; P:regulation of inner ear auditory receptor cell differentiation; IGI:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR002418; Tscrpt_reg_Myc.
DR   InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF01056; Myc_N; 2.
DR   PIRSF; PIRSF001705; Myc_protein; 1.
DR   PRINTS; PR00044; LEUZIPPRMYC.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..368
FT                   /note="Protein L-Myc"
FT                   /id="PRO_0000127334"
FT   DOMAIN          285..337
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          39..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          112..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          337..365
FT                   /note="Leucine-zipper"
FT   COMPBIAS        132..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..260
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        279..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   368 AA;  40848 MW;  9174F6FD7C03321E CRC64;
     MDFDSYQHYF YDYDCGEDFY RSTAPSEDIW KKFELVPSPP TSPPWGSGPG AVDPASGINP
     GEPWPGGGAG DEAESRGHSK AWGRNYASII RRDCMWSGFS ARERLERVVS DRLAPGAPRG
     NPPKAPATPD GTPSLEASNP APATQCQLGE PKTQACSGSE SPSDSEGEEI DVVTVEKRRS
     LDIRKPVTIT VRADPLDPCM KHFHISIHQQ QHNYAARFPP ESCSQEGDPE PGPQEEAPEI
     EAPKEKEEEE EEEEEEEIVS PPPVGSEAPQ SCHPKPVSSD TEDVTKRKNH NFLERKRRND
     LRSRFLALRD QVPTLASCSK APKVVILSKA LEYLQALVGA EKKMATEKRQ LRCRQQQLQK
     RIAYLSGY