ID   MYCN_CHICK              Reviewed;         441 AA.
AC   P18444;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=N-myc proto-oncogene protein;
GN   Name=MYCN;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2183017; DOI=10.1128/mcb.10.5.2017-2026.1990;
RA   Sawai S., Kato K., Wakamatsu Y., Kondoh H.;
RT   "Organization and expression of the chicken N-myc gene.";
RL   Mol. Cell. Biol. 10:2017-2026(1990).
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Binds DNA as a heterodimer with MAX.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; D90071; BAA14112.1; -; Genomic_DNA.
DR   PIR; A34703; TVCHMC.
DR   AlphaFoldDB; P18444; -.
DR   SMR; P18444; -.
DR   STRING; 9031.ENSGALP00000036097; -.
DR   VEuPathDB; HostDB:geneid_421948; -.
DR   eggNOG; KOG2588; Eukaryota.
DR   InParanoid; P18444; -.
DR   PhylomeDB; P18444; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR002418; Tscrpt_reg_Myc.
DR   InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF01056; Myc_N; 1.
DR   PIRSF; PIRSF001705; Myc_protein; 1.
DR   PRINTS; PR00044; LEUZIPPRMYC.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome.
FT   CHAIN           1..441
FT                   /note="N-myc proto-oncogene protein"
FT                   /id="PRO_0000127327"
FT   DOMAIN          358..410
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          49..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          144..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          206..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          410..431
FT                   /note="Leucine-zipper"
FT   COMPBIAS        152..166
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..257
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        349..369
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         240
FT                   /note="Phosphoserine; by CK2"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         242
FT                   /note="Phosphoserine; by CK2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   441 AA;  48697 MW;  176B36CE768FC0CE CRC64;
     MPGMISKNPD LEFDSLQPCF YPDEDDFYLC GPDSAPPGED IWKKFELLPT PPLSPSRAGL
     QEPPPGGGSI AVGRGGPGEC RPVDPLDWAS ELLLLPPEAE LWGSTDGADF FETGLGASNN
     LNSIIIQDCM WSAFSAREKL ERAVSEKLQS KPPAAAPPPP PPVVPTAACR RREQPQRGPG
     RAELGGSVPE CVDPAVVFPF PVNKREAAVP SGGETPRGGR RPGPAGESRA SSSSGDDTLS
     DSDDEDEEEE DDEEEIDVVT VEKRRSSSNK AVTTLTITVR PKNTTFPSVR TQQNELILKR
     CAPIHQQHNY AAPSPYMESE DVPPQKKLKA EVPRPVKPMI QPKSKSSSPR NSDSEDSERR
     RNHNILERQR RNDLRSSFLT LRDHVPELVK NEKAAKVVIL KKATEYVHSL QAEEQKLLLE
     KEKLQARQQQ LLKKIEYKRT C