ID   MYCN_DANRE              Reviewed;          93 AA.
AC   Q9PSJ0;
DT   13-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=N-myc protein;
DE            Short=zN-Myc;
DE   Flags: Fragment;
GN   Name=mycn; Synonyms=nmyc1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo {ECO:0000269|PubMed:8474440};
RX   PubMed=8474440; DOI=10.1128/mcb.13.5.2765-2775.1993;
RA   Schreiber-Agus N., Horner J., Torres R., Chiu F.-C., DePinho R.A.;
RT   "Zebra fish myc family and max genes: differential expression and oncogenic
RT   activity throughout vertebrate evolution.";
RL   Mol. Cell. Biol. 13:2765-2775(1993).
CC   -!- FUNCTION: May function as a transcription factor. {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Binds DNA as a heterodimer with MAX (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Barely detectable in most tissues assayed.
CC       {ECO:0000269|PubMed:8474440}.
CC   -!- DEVELOPMENTAL STAGE: Expression increases significantly between 6 and
CC       12 hours, a period characterized by late gastrulation, early central
CC       nervous system development and early somite formation. Levels increase
CC       during later stages marked by rapid growth and development of the
CC       brain, and formation of rudimentary visual and auditory organs and
CC       myotomes (12 to 24 hours). {ECO:0000269|PubMed:8474440}.
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DR   PIR; D48059; D48059.
DR   AlphaFoldDB; Q9PSJ0; -.
DR   STRING; 7955.ENSDARP00000026640; -.
DR   PaxDb; Q9PSJ0; -.
DR   ZFIN; ZDB-GENE-020711-1; mycn.
DR   eggNOG; KOG2588; Eukaryota.
DR   InParanoid; Q9PSJ0; -.
DR   PRO; PR:Q9PSJ0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR   Pfam; PF01056; Myc_N; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           <1..>93
FT                   /note="N-myc protein"
FT                   /id="PRO_0000127329"
FT   NON_TER         1
FT                   /evidence="ECO:0000303|PubMed:8474440"
FT   NON_TER         93
FT                   /evidence="ECO:0000303|PubMed:8474440"
SQ   SEQUENCE   93 AA;  9811 MW;  B4409B81CB5BE086 CRC64;
     EDIWKKFELL PTPPLSPSRA ALPGDPGELG AVAGDCSLMG FGLTDPLDWA SELLLLPGDD
     IWGASDGDLF GSVLDTTDNS IIIQDCMWSG FSA