ID   MYCN_XENLA              Reviewed;         437 AA.
AC   P24793; A1E5L6;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=N-myc protein;
GN   Name=mycn; Synonyms=nmyc;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2088727; DOI=10.1242/dev.110.3.885;
RA   Vize P.D., Vaughan A., Krieg P.;
RT   "Expression of the N-myc proto-oncogene during the early development of
RT   Xenopus laevis.";
RL   Development 110:885-896(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Vize P.D., Krieg P.A.;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in CNS maturation.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Binds DNA as a heterodimer with MAX.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X58670; CAA41525.1; -; Genomic_DNA.
DR   EMBL; X58671; CAA41525.1; JOINED; Genomic_DNA.
DR   EMBL; EF108321; ABL11345.1; -; mRNA.
DR   PIR; S15704; S15704.
DR   RefSeq; NP_001165460.1; NM_001171989.1.
DR   RefSeq; XP_018117080.1; XM_018261591.1.
DR   AlphaFoldDB; P24793; -.
DR   SMR; P24793; -.
DR   GeneID; 100337516; -.
DR   KEGG; xla:100337516; -.
DR   CTD; 100337516; -.
DR   Xenbase; XB-GENE-6464367; mycn.L.
DR   OMA; PFPINKR; -.
DR   OrthoDB; 877891at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 100337516; Expressed in brain and 17 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR002418; Tscrpt_reg_Myc.
DR   InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF01056; Myc_N; 1.
DR   PIRSF; PIRSF001705; Myc_protein; 1.
DR   PRINTS; PR00044; LEUZIPPRMYC.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome.
FT   CHAIN           1..437
FT                   /note="N-myc protein"
FT                   /id="PRO_0000127330"
FT   DOMAIN          354..406
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          138..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          406..434
FT                   /note="Leucine-zipper"
FT   COMPBIAS        188..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..252
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..365
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         231
FT                   /note="Phosphoserine; by CK2"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         233
FT                   /note="Phosphoserine; by CK2"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   437 AA;  48406 MW;  C4D6EEC0636E6F04 CRC64;
     MPGLVSRNLD LEFDSLQPCF YPDEDDFYLC DPDSAPPGED IWKKFELLPT PPLSPSRSGL
     HGDPLSPGLP GDYGDSVDWA SELLVLPPEA DLLGGSGWGE LGLSPCNVKS IIIQDCMWSG
     FSAREKLERA VSEKLGKASC TPEPTIPHPP SSTVGSSVSG RGVDMNNPAA HCVDPAVVFP
     FPFNKGESCR TAPSSANPPP CTTTTVPTST TARNCTQPCT SSSSSGEESH SESDDDEDEE
     EEEEDDEEEE IDVVTVEKRR NSSNKSVTSL TITVRPKNTI LVSSKTAQNE VILKRCAPVH
     QQHNYAAPSP YVETEEVAPP QKKLRNELPR LVKNVVPTKP KSSSPRNYDS EDSERRRNHN
     ILERQRRNDL RSSFLTLRDH VPELIKNEKA AKVVILKKAT EYVHSLHADE QKLLLEKEKL
     QLRQQQLLKK IEHLRTC