MYCS_MOUSE
ID MYCS_MOUSE Reviewed; 431 AA.
AC Q9Z304; Q3V0Z1;
DT 27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Protein S-Myc;
GN Name=Mycs;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ; TISSUE=Liver;
RX PubMed=9931502; DOI=10.1016/s0378-1119(98)00547-2;
RA Sugiyama A., Noguchi K., Kitanaka C., Katou N., Tashiro F., Ono T.,
RA Yoshida M.C., Kuchino Y.;
RT "Molecular cloning and chromosomal mapping of mouse intronless myc gene
RT acting as a potent apoptosis inducer.";
RL Gene 226:273-283(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has apoptosis-inducing activity.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; AB016289; BAA37155.1; -; Genomic_DNA.
DR EMBL; AK132789; BAE21362.1; -; mRNA.
DR EMBL; BX465847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466841; EDL08935.1; -; Genomic_DNA.
DR EMBL; BC117074; AAI17075.1; -; mRNA.
DR EMBL; BC120777; AAI20778.1; -; mRNA.
DR CCDS; CCDS29953.1; -.
DR RefSeq; NP_034980.2; NM_010850.2.
DR AlphaFoldDB; Q9Z304; -.
DR SMR; Q9Z304; -.
DR STRING; 10090.ENSMUSP00000054158; -.
DR PaxDb; Q9Z304; -.
DR PRIDE; Q9Z304; -.
DR DNASU; 17870; -.
DR Ensembl; ENSMUST00000058404; ENSMUSP00000054158; ENSMUSG00000044597.
DR GeneID; 17870; -.
DR KEGG; mmu:17870; -.
DR UCSC; uc009sks.2; mouse.
DR CTD; 17870; -.
DR MGI; MGI:1332242; Mycs.
DR VEuPathDB; HostDB:ENSMUSG00000044597; -.
DR eggNOG; KOG2588; Eukaryota.
DR GeneTree; ENSGT00940000158432; -.
DR HOGENOM; CLU_052560_0_0_1; -.
DR InParanoid; Q9Z304; -.
DR OMA; GMICKNS; -.
DR OrthoDB; 877891at2759; -.
DR PhylomeDB; Q9Z304; -.
DR TreeFam; TF106001; -.
DR BioGRID-ORCS; 17870; 3 hits in 74 CRISPR screens.
DR PRO; PR:Q9Z304; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9Z304; protein.
DR Bgee; ENSMUSG00000044597; Expressed in vastus lateralis and 2 other tissues.
DR Genevisible; Q9Z304; MM.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0019900; F:kinase binding; ISO:MGI.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002418; Tscrpt_reg_Myc.
DR InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF01056; Myc_N; 1.
DR PIRSF; PIRSF001705; Myc_protein; 1.
DR PRINTS; PR00044; LEUZIPPRMYC.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; DNA-binding; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..431
FT /note="Protein S-Myc"
FT /id="PRO_0000127341"
FT DOMAIN 348..400
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 400..421
FT /note="Leucine-zipper"
FT MOD_RES 36
FT /note="Phosphotyrosine; by Tyr-kinases"
FT /evidence="ECO:0000250"
FT CONFLICT 340
FT /note="N -> K (in Ref. 1; BAA37155)"
FT /evidence="ECO:0000305"
FT CONFLICT 427
FT /note="Q -> P (in Ref. 1; BAA37155)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 431 AA; 47680 MW; AA698DAFE58F1F07 CRC64;
MLSCTTSTMP GMICKNSDLE FDLLKPCFYP EEDDIYFGGH NSTPPGEDIW KKFELLPTPR
LSPDSALAEH SLEPVNWATE MLLPEADLWS NPGEEEVFGQ GGLRGCTSNP IILQDCMWSG
FSNPGKPESV VSEKLPGGYR SLAVGAGTLA PGAAAAASSA GHERSGTAGV GRGKAAWLTE
LSHLDLECVD PAVVFFPANK REPMPVPTIP TSTGSAISLG DHQGLSSSLE DFLSNSGSVE
EGGEEIYVVM LEETQFSKTV SRLPTAAHQE NAALSPGCAQ SSELILKRYD LIQEQHNYAA
PPLPYVDRED ARPQKKPRSH TSLALKCVFR PKAPRLGSRN NSDWENIERR RNHNRMERQR
RDIMRSSFLN LRDLVPELVH NEKAAKVVIL KKATEYIHTL QADESKLLVE RKKLYERQQQ
LLQKIKQYAL C
