ID   MYCS_RAT                Reviewed;         429 AA.
AC   P23999;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Protein S-Myc;
GN   Name=Mycs;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2594755; DOI=10.1073/pnas.86.23.9144;
RA   Sugiyama A., Kume A., Nemoto K., Lee S.Y., Asami Y., Nemoto F.,
RA   Nishimura S., Kuchino Y.;
RT   "Isolation and characterization of s-myc, a member of the rat myc gene
RT   family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:9144-9148(1989).
CC   -!- FUNCTION: Has apoptosis-inducing activity.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; M29069; AAA41645.1; -; Genomic_DNA.
DR   PIR; A36220; A36220.
DR   RefSeq; NP_068609.1; NM_021837.1.
DR   AlphaFoldDB; P23999; -.
DR   SMR; P23999; -.
DR   STRING; 10116.ENSRNOP00000004118; -.
DR   PaxDb; P23999; -.
DR   GeneID; 24581; -.
DR   KEGG; rno:24581; -.
DR   UCSC; RGD:3133; rat.
DR   CTD; 17870; -.
DR   RGD; 3133; Mycs.
DR   eggNOG; KOG2588; Eukaryota.
DR   InParanoid; P23999; -.
DR   OrthoDB; 877891at2759; -.
DR   PhylomeDB; P23999; -.
DR   PRO; PR:P23999; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR002418; Tscrpt_reg_Myc.
DR   InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF01056; Myc_N; 1.
DR   PIRSF; PIRSF001705; Myc_protein; 1.
DR   PRINTS; PR00044; LEUZIPPRMYC.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   3: Inferred from homology;
KW   Apoptosis; DNA-binding; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..429
FT                   /note="Protein S-Myc"
FT                   /id="PRO_0000127342"
FT   DOMAIN          346..398
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          301..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          398..419
FT                   /note="Leucine-zipper"
FT   MOD_RES         36
FT                   /note="Phosphotyrosine; by Tyr-kinases"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   429 AA;  47002 MW;  1E79FF90747FD0FA CRC64;
     MLSCTTSTMP GMICKNSDLE FDSLKPCFYP EDDDIYFGGR NSTPPGEDIW KKFELLPTPR
     LSPGRALAED SLEPANWATE MLLPEADLWS NPAEEEDIFG LKGLSGSSSN PVVLQDCMWS
     GFSSREKPET VVSEKLPGGC GSLAVGAGTL VPGAAAATSA GHARSGTAGV GRRKAAWLTE
     LSHLDSECVD SAVIFPANKR ESMPVATIPA SAGAAISLGD HQGLSSSLED FLSNSGYVEE
     GGEEIYVVML GETQFSKTVT KLPTAAHSEN AALTPECAQS GELILKRSDL IQEQHNYAAP
     PLPYAEDARP LKKPRSQDPL GPLKCVLRPK APRLRSRSNS DLEDIERRRN HNRMERQRRD
     IMRSSFLNLR DLVPELVHNE KAAKVVILKK ATEYIHTLQT DESKLLVERE KLYERKQQLL
     EKIKQSAVC