MYCT1_HUMAN
ID MYCT1_HUMAN Reviewed; 235 AA.
AC Q8N699; Q8N396; Q8TBE8; Q9H763;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Myc target protein 1;
DE AltName: Full=Myc target in myeloid cells protein 1;
GN Name=MYCT1; Synonyms=MTLC, MTMC1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RC TISSUE=Laryngeal carcinoma;
RX PubMed=12673574;
RA Qiu G.-B., Qiu G., Xu Z., Huang D., Gong L.-G., Li C., Sun X., Sun K.-L.;
RT "Cloning and characterization of MTLC, a novel gene in 6q25.";
RL Zhonghua Yi Xue Yi Chuan Xue Za Zhi 20:94-97(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-127.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 32-235.
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP EXPRESSION IN GASTRIC CARCINOMA.
RX PubMed=14562369; DOI=10.3748/wjg.v9.i10.2160;
RA Qiu G.-B., Gong L.-G., Hao D.-M., Zhen Z.-H., Sun K.-L.;
RT "Expression of MTLC gene in gastric carcinoma.";
RL World J. Gastroenterol. 9:2160-2163(2003).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: May regulate certain MYC target genes, MYC seems to be a
CC direct upstream transcriptional activator. Does not seem to
CC significantly affect growth cell capacity. Overexpression seems to
CC mediate many of the known phenotypic features associated with MYC,
CC including promotion of apoptosis, alteration of morphology, enhancement
CC of anchorage-independent growth, tumorigenic conversion, promotion of
CC genomic instability, and inhibition of hematopoietic differentiation
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12673574}.
CC Note=Expressed in nuclei of hepatocellular carcinoma cell line BEL-7402
CC cells.
CC -!- TISSUE SPECIFICITY: Down-regulated in gastric cancer tissues.
CC -!- SIMILARITY: Belongs to the MYCT1 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-49 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AF527367; AAM88866.1; -; mRNA.
DR EMBL; AK024922; BAB15035.1; -; mRNA.
DR EMBL; AL390960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW47726.1; -; Genomic_DNA.
DR EMBL; BC022556; AAH22556.2; -; mRNA.
DR EMBL; BC128463; AAI28464.1; -; mRNA.
DR EMBL; BC128464; AAI28465.1; -; mRNA.
DR EMBL; AL834500; CAD39158.3; -; mRNA.
DR CCDS; CCDS5239.1; -.
DR RefSeq; NP_079383.2; NM_025107.2.
DR RefSeq; XP_011534451.1; XM_011536149.2.
DR RefSeq; XP_011534452.1; XM_011536150.2.
DR RefSeq; XP_011534453.1; XM_011536151.2.
DR RefSeq; XP_011534454.1; XM_011536152.2.
DR RefSeq; XP_016866808.1; XM_017011319.1.
DR AlphaFoldDB; Q8N699; -.
DR BioGRID; 123159; 8.
DR IntAct; Q8N699; 7.
DR MINT; Q8N699; -.
DR STRING; 9606.ENSP00000356214; -.
DR iPTMnet; Q8N699; -.
DR PhosphoSitePlus; Q8N699; -.
DR SwissPalm; Q8N699; -.
DR BioMuta; MYCT1; -.
DR DMDM; 74751049; -.
DR jPOST; Q8N699; -.
DR MassIVE; Q8N699; -.
DR PaxDb; Q8N699; -.
DR PeptideAtlas; Q8N699; -.
DR PRIDE; Q8N699; -.
DR ProteomicsDB; 72150; -.
DR Antibodypedia; 55356; 129 antibodies from 23 providers.
DR DNASU; 80177; -.
DR Ensembl; ENST00000367245.6; ENSP00000356214.5; ENSG00000120279.7.
DR GeneID; 80177; -.
DR KEGG; hsa:80177; -.
DR MANE-Select; ENST00000367245.6; ENSP00000356214.5; NM_025107.3; NP_079383.2.
DR UCSC; uc003qpc.5; human.
DR CTD; 80177; -.
DR DisGeNET; 80177; -.
DR GeneCards; MYCT1; -.
DR HGNC; HGNC:23172; MYCT1.
DR HPA; ENSG00000120279; Tissue enhanced (lymphoid).
DR neXtProt; NX_Q8N699; -.
DR OpenTargets; ENSG00000120279; -.
DR PharmGKB; PA134908917; -.
DR VEuPathDB; HostDB:ENSG00000120279; -.
DR eggNOG; ENOG502RXWU; Eukaryota.
DR GeneTree; ENSGT00390000011642; -.
DR InParanoid; Q8N699; -.
DR OMA; PEFHWSN; -.
DR OrthoDB; 1364750at2759; -.
DR PhylomeDB; Q8N699; -.
DR TreeFam; TF333196; -.
DR PathwayCommons; Q8N699; -.
DR SignaLink; Q8N699; -.
DR SIGNOR; Q8N699; -.
DR BioGRID-ORCS; 80177; 15 hits in 1071 CRISPR screens.
DR ChiTaRS; MYCT1; human.
DR GenomeRNAi; 80177; -.
DR Pharos; Q8N699; Tbio.
DR PRO; PR:Q8N699; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8N699; protein.
DR Bgee; ENSG00000120279; Expressed in lower lobe of lung and 166 other tissues.
DR ExpressionAtlas; Q8N699; baseline and differential.
DR Genevisible; Q8N699; HS.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0061484; P:hematopoietic stem cell homeostasis; IEA:Ensembl.
DR InterPro; IPR029180; Myc_target_1.
DR PANTHER; PTHR14869; PTHR14869; 1.
DR Pfam; PF15179; Myc_target_1; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..235
FT /note="Myc target protein 1"
FT /id="PRO_0000310959"
FT MOTIF 95..113
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOD_RES 135
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R411"
FT MOD_RES 138
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R411"
FT MOD_RES 141
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R411"
FT MOD_RES 149
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R411"
FT VARIANT 119
FT /note="G -> S (in dbSNP:rs17710008)"
FT /id="VAR_037115"
FT VARIANT 127
FT /note="R -> G (in dbSNP:rs17852097)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037116"
FT CONFLICT 147
FT /note="Q -> R (in Ref. 2; BAB15035)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 235 AA; 26593 MW; 880ADD4C9598F53F CRC64;
MRTQVYEGLC KNYFSLAVLQ RDRIKLLFFD ILVFLSVFLL FLLFLVDIMA NNTTSLGSPW
PENFWEDLIM SFTVSMAIGL VLGGFIWAVF ICLSRRRRAS APISQWSSSR RSRSSYTHGL
NRTGFYRHSG CERRSNLSLA SLTFQRQASL EQANSFPRKS SFRASTFHPF LQCPPLPVET
ESQLVTLPSS NISPTISTSH SLSRPDYWSS NSLRVGLSTP PPPAYESIIK AFPDS
