ID   MYC_ASTRU               Reviewed;         407 AA.
AC   Q17103;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Myc protein;
DE   AltName: Full=c-myc;
DE   Flags: Fragment;
GN   Name=MYC;
OS   Asterias rubens (Common European starfish) (Asterias vulgaris).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea;
OC   Forcipulatacea; Forcipulatida; Asteriidae; Asterias.
OX   NCBI_TaxID=7604;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1408141;
RA   Walker C.W., Boom J.D., Marsh A.G.;
RT   "First non-vertebrate member of the myc gene family is seasonally expressed
RT   in an invertebrate testis.";
RL   Oncogene 7:2007-2012(1992).
CC   -!- FUNCTION: Transcription factor that binds DNA in a non-specific manner,
CC       yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'.
CC       Activates the transcription of growth-related genes.
CC       {ECO:0000250|UniProtKB:P01106}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; M80364; AAA27788.1; -; mRNA.
DR   PIR; S27774; S27774.
DR   AlphaFoldDB; Q17103; -.
DR   SMR; Q17103; -.
DR   PRIDE; Q17103; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR002418; Tscrpt_reg_Myc.
DR   InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF01056; Myc_N; 1.
DR   PIRSF; PIRSF001705; Myc_protein; 1.
DR   PRINTS; PR00044; LEUZIPPRMYC.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           <1..407
FT                   /note="Myc protein"
FT                   /id="PRO_0000127321"
FT   DOMAIN          321..373
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          284..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          380..401
FT                   /note="Leucine-zipper"
FT   COMPBIAS        58..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        284..314
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   407 AA;  45673 MW;  F4E52DD01182113A CRC64;
     ARVPDDDMNS LEDSDSMESC FAGEEEFYSS TLTPPTPSED IWKKFELYPT PPLSPSHNPD
     DKESDRHPRH HQQDGDGSPS RSYQHLMDDD DLPLVNPQVP LLDLSSAPPI AALIQDCMWS
     SIIAEERRKL FMKSEKKHAE ERATKKASTP SSGVMLPPLV PASEYGTSDC VDPSAVCPYP
     LSETRLDLFS SGTNTPSDSE EEIDVVTVEK KHHSVHKINT TRPYHKQSTK VRHQLHHRPI
     SVALVGSLRG RPSTATILSI PIKKLKTEGN LEEVKQILQK SNLIRSSSGS SRGSSRGCSR
     NSSSRRVNQV SHPSSDSEDT EKRACHNVLE RQRREDLRTS FLLLRDEVPE LGTCDRAAKV
     VILKKATDYV SSLRDREETL RMDMATEKNR NLQLRRRLEA LLAPLTL