ID   MYC_AVIMC               Reviewed;         416 AA.
AC   P01110;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 2.
DT   23-FEB-2022, entry version 135.
DE   RecName: Full=Viral myc transforming protein;
DE            Short=v-Myc;
GN   Name=MYC;
OS   Avian myelocytomatosis virus MC29.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Alpharetrovirus.
OX   NCBI_TaxID=11868;
OH   NCBI_TaxID=8976; Galliformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6302688; DOI=10.1073/pnas.80.9.2500;
RA   Reddy E.P., Reynolds R.K., Watson D.K., Schultz R.A., Lautenberger J.,
RA   Papas T.S.;
RT   "Nucleotide sequence analysis of the proviral genome of avian
RT   myelocytomatosis virus (MC29).";
RL   Proc. Natl. Acad. Sci. U.S.A. 80:2500-2504(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6296857; DOI=10.1073/pnas.80.1.100;
RA   Alitalo K., Bishop J.M., Smith D.H., Chen E.Y., Colby W.W., Levinson A.D.;
RT   "Nucleotide sequence to the v-myc oncogene of avian retrovirus MC29.";
RL   Proc. Natl. Acad. Sci. U.S.A. 80:100-104(1983).
CC   -!- FUNCTION: Transforms avian and murine macrophages and fibroblasts as
CC       well as murine B-lymphoid cells.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is synthesized as a Gag-vMyc chimeric
CC       protein. The sequence shown here corresponds to the Myc homolog
CC       fragment of the chimera.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA24498.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=CAA24499.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; V01173; CAA24498.1; ALT_INIT; Genomic_DNA.
DR   EMBL; V01174; CAA24499.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_045935.1; NC_001866.1.
DR   SMR; P01110; -.
DR   MINT; P01110; -.
DR   GeneID; 1491913; -.
DR   KEGG; vg:1491913; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003327; Myc-LZ.
DR   InterPro; IPR002418; Tscrpt_reg_Myc.
DR   InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF02344; Myc-LZ; 1.
DR   Pfam; PF01056; Myc_N; 1.
DR   PIRSF; PIRSF001705; Myc_protein; 1.
DR   PRINTS; PR00044; LEUZIPPRMYC.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Host nucleus; Oncogene.
FT   CHAIN           1..416
FT                   /note="Viral myc transforming protein"
FT                   /id="PRO_0000127308"
FT   DOMAIN          331..383
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          144..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..267
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          383..411
FT                   /note="Leucine-zipper"
FT   COMPBIAS        153..171
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..244
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..336
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        146
FT                   /note="Q -> R (in Ref. 2; CAA24498)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        389
FT                   /note="K -> R (in Ref. 2; CAA24498)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   416 AA;  46095 MW;  1B5D6DB1D52EE209 CRC64;
     MPLSASLPSK NYDYDYDSVQ PYFYFEEEEE NFYLAAQQRG SELQPPAPSE DIWKKFELLP
     MPPLSPSRRS SLAAASCFPS TADQLEMVTE LLGGDMVNQS FICDPDDESF VKSIIIQDCM
     WSGFSAAAKL EKVVSEKLAT YQASRQEGGP AAASRPGPPP SGPPPPPAGP AASAGLYLHD
     LGAAAADCID PSVVFPYPLS ERAPRAAPPG ANPAALLGVD TPPTTSSDSE EEQEEDEEID
     VVTLAEANES ESSTESSTEA SEEHCKPHHS PLVLKRCHVN IHQHNYAAPP STKVEYPAAK
     RLKLDSGRVL KQISNNRKCS SPRTLDSEEN DKRRTHNVLE RQRRNELKLR FFALRDQIPE
     VANNEKAPKV VILKKATEYV LSLQSDEHKL IAEKEQLRRR REQLKHNLEQ LRNSRA