ID   MYC_AVIME               Reviewed;         412 AA.
AC   P0C0N8; P06647;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   02-JUN-2021, entry version 78.
DE   RecName: Full=Viral myc transforming protein;
DE            Short=v-Myc;
GN   Name=MYC;
OS   Avian retrovirus MH2E21.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Alpharetrovirus.
OX   NCBI_TaxID=11916;
OH   NCBI_TaxID=8976; Galliformes.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3016301; DOI=10.1128/jvi.59.2.341-353.1986;
RA   Patschinsky T., Jansen H.W., Bloecker H., Frank R., Bister K.;
RT   "Structure and transforming function of transduced mutant alleles of the
RT   chicken c-myc gene.";
RL   J. Virol. 59:341-353(1986).
CC   -!- FUNCTION: Transforms avian and murine macrophages and fibroblasts as
CC       well as murine B-lymphoid cells. {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is synthesized as a Gag-vMyc chimeric
CC       protein. The sequence shown here corresponds to the Myc homolog
CC       fragment of the chimera.
CC   -!- MISCELLANEOUS: The MH2E21 virus appears to be a recombinant between
CC       ring-necked pheasant virus and a deletion mutant of MH2 that was
CC       constructed in vitro. The MH2E21 virus lacks Gag, Pol and Env genes,
CC       and thus needs a helper virus to reproduce.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA42389.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M14008; AAA42389.1; ALT_INIT; Genomic_RNA.
DR   PIR; A29285; TVFV2E.
DR   SMR; P0C0N8; -.
DR   PRIDE; P0C0N8; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003327; Myc-LZ.
DR   InterPro; IPR002418; Tscrpt_reg_Myc.
DR   InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF02344; Myc-LZ; 1.
DR   Pfam; PF01056; Myc_N; 2.
DR   PIRSF; PIRSF001705; Myc_protein; 1.
DR   PRINTS; PR00044; LEUZIPPRMYC.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Host nucleus; Oncogene.
FT   CHAIN           1..412
FT                   /note="Viral myc transforming protein"
FT                   /id="PRO_0000127305"
FT   DOMAIN          327..379
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          144..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          208..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          386..407
FT                   /note="Leucine-zipper"
FT   COMPBIAS        153..171
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..240
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   412 AA;  45162 MW;  19A1248A5E9A0FB1 CRC64;
     MPLSVSLPSK NYDYDYDSVQ PYFYFEEEEE NFYLAAQQRS SELQPPAPSE DIWKKFELLP
     APPLSPSCRS NLAAASCFPS TADQLEMVTE LLGGDMVNQS SICDPDDESF VKSIIIRDCM
     WSGFSAAAKL EKVVSEKLAT YKASRREGGP AAASRPGPPP SGPPPPPAGP AASAGLYLHD
     LGAAAAGCIG SSVVFPCPLG RRGPPGAGPA ALLGVDAPPT AGGGSEEEQE EDEEIDVVTL
     AEANESESST ESSTEASEEH CKPHHSPLVL ERCHVNIHQH NYAAPPSTKV EYPAAKRLKL
     DSGRVLKQVS NNRKCSSPRT SDSEVNDKRR THNVLERQRR NELKLSFFAL RDQIPEVANN
     EKAPKVVILK RATEYVLSIQ SDEHRLIAEK EQLRRRREQL KHKLEQLRNS RA