ID   MYC_CARAU               Reviewed;         399 AA.
AC   P49709;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Transcriptional regulator Myc;
DE            Short=c-Myc;
GN   Name=myc;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Zhang H., Zhang H., Okamoto N., Ikeda Y.;
RT   "Cloning and sequencing of a c-myc gene from goldfish Carassius autatus.";
RL   Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that binds DNA in a non-specific manner,
CC       yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'.
CC       Activates the transcription of growth-related genes.
CC       {ECO:0000250|UniProtKB:P01106}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Binds DNA as a heterodimer with MAX.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000250|UniProtKB:P01106}.
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DR   EMBL; D31729; BAA06527.1; -; Genomic_DNA.
DR   AlphaFoldDB; P49709; -.
DR   SMR; P49709; -.
DR   PRIDE; P49709; -.
DR   Ensembl; ENSCART00000123522; ENSCARP00000110425; ENSCARG00000056880.
DR   Proteomes; UP000515129; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0032502; P:developmental process; IEA:UniProt.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR003327; Myc-LZ.
DR   InterPro; IPR002418; Tscrpt_reg_Myc.
DR   InterPro; IPR012682; Tscrpt_reg_Myc_N.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF02344; Myc-LZ; 1.
DR   Pfam; PF01056; Myc_N; 1.
DR   PIRSF; PIRSF001705; Myc_protein; 1.
DR   PRINTS; PR00044; LEUZIPPRMYC.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Glycoprotein; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..399
FT                   /note="Transcriptional regulator Myc"
FT                   /id="PRO_0000127315"
FT   DOMAIN          315..367
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          177..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..320
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          374..395
FT                   /note="Leucine-zipper"
FT   MOTIF           76..84
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000250|UniProtKB:P01106"
FT   COMPBIAS        177..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..233
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..249
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        58
FT                   /note="O-linked (GlcNAc) threonine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   399 AA;  45756 MW;  FC4B2CEC361F1D42 CRC64;
     MPVSASLAYK NYDYDYDSIQ PYFYFDNDDE DFYHHQQGQP QPPAPSEDIW KKFELLPTPP
     LSPSRRQSLS TAEQLEMVSE FLGDDVVNQS FICDADYSQS FIKSIIIQDC MWSGFSAAAK
     LEKAVSERLA SLHAARKELI SDSSSNRLSA SYLQDLSTSA SECIDPSVVF PYPLTESSKS
     NKVAPSQPML VLDTPPNSSS SSGSDSEDEE EEEEEEEEEE EEEEEEEEEE EIDVVTVEKR
     QKRNEADVSD SRYPSPLVLK RCHVSTHQHN YAAHPSTRHD QPAVKRLRLE TSSSNRHGKQ
     RKCTSPRTSD SEDNDKRRTH NVLERQRRNE LKLSFFALRD EIPEVANNEK AAKVVILKKA
     TECIHSMQLD EQRLLSIKEQ LRRKSEQLKH RLQQLRSSH