MYD88_CHICK
ID MYD88_CHICK Reviewed; 299 AA.
AC A5HNF6; A0FIQ0; Q5F3L0;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Myeloid differentiation primary response protein MyD88;
GN Name=MYD88; ORFNames=RCJMB04_14h3;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Spleen;
RX PubMed=17676477; DOI=10.1080/10425170701295856;
RA Wheaton S., Lambourne M.D., Sarson A.J., Brisbin J.T., Mayameei A.,
RA Sharif S.;
RT "Molecular cloning and expression analysis of chicken MyD88 and TRIF
RT genes.";
RL DNA Seq. 18:480-486(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=White leghorn; TISSUE=Bursa of Fabricius;
RX PubMed=18582498; DOI=10.1016/j.dci.2008.05.016;
RA Qiu Y., Shen Y., Li X., Ding C., Ma Z.;
RT "Molecular cloning and functional characterization of a novel isoform of
RT chicken myeloid differentiation factor 88 (MyD88).";
RL Dev. Comp. Immunol. 32:1522-1530(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1
CC receptor signaling pathway in the innate immune response. {ECO:0000250,
CC ECO:0000269|PubMed:18582498}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18582498}. Nucleus
CC {ECO:0000269|PubMed:18582498}. Note=Predominantly cytoplasmic, with
CC some expression in the nucleus.
CC -!- TISSUE SPECIFICITY: Expressed in spleen, liver, kidney, bursa of
CC Fabricius, lung and brain (at protein level). Expressed in cecum,
CC heart, spleen, liver, kidney, female reproductive tract, thymus, bursa
CC of Fabricius, muscle and lung. {ECO:0000269|PubMed:17676477,
CC ECO:0000269|PubMed:18582498}.
CC -!- DOMAIN: The intermediate domain (ID) is required for the
CC phosphorylation and activation of IRAK. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABJ98316.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=CAH65274.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; EF011109; ABJ98316.1; ALT_FRAME; mRNA.
DR EMBL; EF544486; ABQ17966.1; -; mRNA.
DR EMBL; AJ851640; CAH65274.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001026133.2; NM_001030962.3.
DR AlphaFoldDB; A5HNF6; -.
DR SMR; A5HNF6; -.
DR STRING; 9031.ENSGALP00000042597; -.
DR PaxDb; A5HNF6; -.
DR Ensembl; ENSGALT00000044477; ENSGALP00000042597; ENSGALG00000005947.
DR GeneID; 420420; -.
DR KEGG; gga:420420; -.
DR CTD; 4615; -.
DR VEuPathDB; HostDB:geneid_420420; -.
DR eggNOG; ENOG502QWKI; Eukaryota.
DR GeneTree; ENSGT00510000048324; -.
DR HOGENOM; CLU_045884_0_0_1; -.
DR InParanoid; A5HNF6; -.
DR OMA; CTQSWFW; -.
DR OrthoDB; 890418at2759; -.
DR PhylomeDB; A5HNF6; -.
DR Reactome; R-GGA-3134963; DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
DR Reactome; R-GGA-433822; NFkB and MAPK activation mediated by TRAF6.
DR Reactome; R-GGA-451477; MyD88-dependent cascade initiated on endosome membrane.
DR Reactome; R-GGA-451514; MyD88:TIRAP-dependent cascade initiated on plasma membrane.
DR Reactome; R-GGA-573298; NFkB and MAPK activation mediated by TRAF6 upon TLR7 or TLR21 stimulation.
DR Reactome; R-GGA-9020702; Interleukin-1 signaling.
DR Reactome; R-GGA-977240; MyD88 cascade initiated on plasma membrane.
DR PRO; PR:A5HNF6; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000005947; Expressed in spleen and 13 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:AgBase.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IDA:AgBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR GO; GO:0035325; F:Toll-like receptor binding; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; NAS:AgBase.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; IMP:AgBase.
DR GO; GO:0008063; P:Toll signaling pathway; IBA:GO_Central.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; TAS:AgBase.
DR CDD; cd08312; Death_MyD88; 1.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 3.40.50.10140; -; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR034249; MyD88_Death.
DR InterPro; IPR017281; Myelin_different_resp_MyD88.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR15079; PTHR15079; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13676; TIR_2; 1.
DR PIRSF; PIRSF037756; MyD88; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF52200; SSF52200; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Immunity; Inflammatory response; Innate immunity; Nucleus;
KW Reference proteome.
FT CHAIN 1..299
FT /note="Myeloid differentiation primary response protein
FT MyD88"
FT /id="PRO_0000393140"
FT DOMAIN 34..113
FT /note="Death"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT DOMAIN 162..296
FT /note="TIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT REGION 114..158
FT /note="Intermediate domain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 299 AA; 33781 MW; 62138CF9E06B02B3 CRC64;
MATVPVGAGS APGPEPADLH SVPMVALNYG VRRRLGLYLN PRAATAADWT ALAEKLGHDY
LEIRRLEALP DPTAALLEEW QSRCPGGATV GQLLELLRQL GRHDVLLELG GSVEEDCKKY
LRRKQQEAEQ PLQVPAVDSS VPKTSELMGI TTRDDPYGHG TEMFDAFICY CQKDLQFVQE
MIRELEQTEF KLKLCVFDRD VLPGTCVWSI SGELIERRCR RMVVVISDDY LESDECDFQT
KFALSLSPGA RLKRLIPVKC KTMKNEFPSI LRFITICDYT NPCTKKWFWT RLAKSLLLP
