MYD88_DANRE
ID MYD88_DANRE Reviewed; 284 AA.
AC Q5XJ85; Q45VT5; Q6TQG4; Q6TS40;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Myeloid differentiation primary response protein MyD88;
GN Name=myd88;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Tuebingen;
RX PubMed=14687934; DOI=10.1016/j.molimm.2003.10.003;
RA Meijer A.H., Krens S.F.G., Medina Rodriguez I.A., He S., Bitter W.,
RA Snaar-Jagalska B.E., Spaink H.P.;
RT "Expression analysis of the Toll-like receptor and TIR domain adaptor
RT families of zebrafish.";
RL Mol. Immunol. 40:773-783(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=16552074; DOI=10.1128/iai.74.4.2436-2441.2006;
RA van der Sar A.M., Stockhammer O.W., van der Laan C., Spaink H.P.,
RA Bitter W., Meijer A.H.;
RT "MyD88 innate immune function in a zebrafish embryo infection model.";
RL Infect. Immun. 74:2436-2441(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Adapter protein involved in the Toll-like receptor and Il-1
CC receptor signaling pathway in the innate immune response.
CC {ECO:0000269|PubMed:16552074}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expression is highest in adults. In the embryo,
CC maternal transcript levels are reduced during blastula and gastrula
CC stages. Expression increases during segmentation and later stages.
CC {ECO:0000269|PubMed:16552074}.
CC -!- DOMAIN: The intermediate domain (ID) is required for the
CC phosphorylation and activation of IRAK. {ECO:0000250}.
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DR EMBL; AY388401; AAQ90476.1; -; mRNA.
DR EMBL; AY389463; AAQ91324.1; -; mRNA.
DR EMBL; DQ100359; AAZ16494.1; -; mRNA.
DR EMBL; BC083419; AAH83419.1; -; mRNA.
DR RefSeq; NP_997979.2; NM_212814.2.
DR AlphaFoldDB; Q5XJ85; -.
DR SMR; Q5XJ85; -.
DR STRING; 7955.ENSDARP00000020711; -.
DR PaxDb; Q5XJ85; -.
DR GeneID; 403145; -.
DR KEGG; dre:403145; -.
DR CTD; 4615; -.
DR ZFIN; ZDB-GENE-040219-3; myd88.
DR eggNOG; ENOG502QWKI; Eukaryota.
DR InParanoid; Q5XJ85; -.
DR OrthoDB; 890418at2759; -.
DR PhylomeDB; Q5XJ85; -.
DR TreeFam; TF326264; -.
DR Reactome; R-DRE-1810476; RIP-mediated NFkB activation via ZBP1.
DR Reactome; R-DRE-209543; p75NTR recruits signalling complexes.
DR Reactome; R-DRE-3134963; DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
DR Reactome; R-DRE-9020702; Interleukin-1 signaling.
DR PRO; PR:Q5XJ85; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR GO; GO:0035325; F:Toll-like receptor binding; IBA:GO_Central.
DR GO; GO:0002218; P:activation of innate immune response; IMP:ZFIN.
DR GO; GO:0042742; P:defense response to bacterium; IMP:ZFIN.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IMP:ZFIN.
DR GO; GO:0042117; P:monocyte activation; IMP:ZFIN.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0002283; P:neutrophil activation involved in immune response; IMP:ZFIN.
DR GO; GO:0030593; P:neutrophil chemotaxis; IMP:ZFIN.
DR GO; GO:1901534; P:positive regulation of hematopoietic progenitor cell differentiation; IMP:ZFIN.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR GO; GO:1901532; P:regulation of hematopoietic progenitor cell differentiation; IGI:ZFIN.
DR GO; GO:0002237; P:response to molecule of bacterial origin; IMP:ZFIN.
DR GO; GO:0008063; P:Toll signaling pathway; IBA:GO_Central.
DR CDD; cd08312; Death_MyD88; 1.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 3.40.50.10140; -; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR034249; MyD88_Death.
DR InterPro; IPR017281; Myelin_different_resp_MyD88.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR15079; PTHR15079; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037756; MyD88; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF52200; SSF52200; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Immunity; Inflammatory response; Innate immunity;
KW Reference proteome.
FT CHAIN 1..284
FT /note="Myeloid differentiation primary response protein
FT MyD88"
FT /id="PRO_0000393141"
FT DOMAIN 24..101
FT /note="Death"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT DOMAIN 147..281
FT /note="TIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT REGION 102..143
FT /note="Intermediate domain"
FT /evidence="ECO:0000250"
FT CONFLICT 7
FT /note="I -> L (in Ref. 1; AAQ90476)"
FT /evidence="ECO:0000305"
FT CONFLICT 60
FT /note="D -> E (in Ref. 2; AAZ16494)"
FT /evidence="ECO:0000305"
FT CONFLICT 135
FT /note="I -> V (in Ref. 3; AAH83419)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 284 AA; 32874 MW; 2A8A843356BD4203 CRC64;
MASKLSIDHE AIPVTALNCS FRKKLGLFLN PTNTVAADWR TVAELMDFTY LEIKNFEKRD
CPFEKVLTDW ETRPDATVAN LLSILEKAER KDVISELKEI LDDDCRKYME RQQRKPLQVP
VVDSCGPRTQ EREGITLYDD PQGLTPETFD AFICYCQSDI QFVHEMIKQL EHTEYNLKLC
VFDRDVLPGT CVWTIASELI EKRCKRMVVV ISDDYLDSDA CDFQTKFALS LCPGARTKRL
IPVVYKSMKR PFPSILRFLT ICDYSKPCTQ VWFWTRLAKA LSLP
