ID   MYD88_ONCMY             Reviewed;         282 AA.
AC   Q4LBC6;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Myeloid differentiation primary response protein MyD88;
GN   Name=myd88;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=19362743; DOI=10.1016/j.vetimm.2009.03.006;
RA   Rebl A., Goldammer T., Fischer U., Kollner B., Seyfert H.M.;
RT   "Characterization of two key molecules of teleost innate immunity from
RT   rainbow trout (Oncorhynchus mykiss): MyD88 and SAA.";
RL   Vet. Immunol. Immunopathol. 131:122-126(2009).
CC   -!- FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1
CC       receptor signaling pathway in the innate immune response.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The intermediate domain (ID) is required for the
CC       phosphorylation and activation of IRAK. {ECO:0000250}.
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DR   EMBL; AJ878918; CAI48087.1; -; mRNA.
DR   RefSeq; NP_001117893.1; NM_001124421.1.
DR   AlphaFoldDB; Q4LBC6; -.
DR   SMR; Q4LBC6; -.
DR   GeneID; 100136123; -.
DR   KEGG; omy:100136123; -.
DR   CTD; 4615; -.
DR   OrthoDB; 890418at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:AgBase.
DR   GO; GO:0016234; C:inclusion body; IDA:AgBase.
DR   GO; GO:0005634; C:nucleus; IDA:AgBase.
DR   GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR   CDD; cd08312; Death_MyD88; 1.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 3.40.50.10140; -; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR034249; MyD88_Death.
DR   InterPro; IPR017281; Myelin_different_resp_MyD88.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR15079; PTHR15079; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   PIRSF; PIRSF037756; MyD88; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF52200; SSF52200; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Immunity; Inflammatory response; Innate immunity.
FT   CHAIN           1..282
FT                   /note="Myeloid differentiation primary response protein
FT                   MyD88"
FT                   /id="PRO_0000393142"
FT   DOMAIN          22..99
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT   DOMAIN          145..279
FT                   /note="TIR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT   REGION          100..141
FT                   /note="Intermediate domain"
FT                   /evidence="ECO:0000250"
FT   REGION          117..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   282 AA;  32552 MW;  CA6D237CCFBB3CDC CRC64;
     MSASLDLWNI PLRALNINVR KRLGLFLNPR NTVASDWMSV AENMGFSYLE IKNYEDCQDP
     TRKIYRTGKP LSRAQVGKLV SILDNVTRKD VVEDLRVLIE EDCKRYIERQ NEPPVQVPEV
     DSCVPRTPER QGITLEDDPE GGIPELFDAF ICYCQSDFDF VHEMIQQLEQ TDHKLKLCVF
     DRDALPGSCV WTITSELIEK RCKRMVVVIS DEYLDSDACD FQTKFALSLC PGARSKRLIP
     VKYKSMKKPF PSILRFLTVC DYPRPCTQSW FWVRLAKALS LP