MYD88_SALSA
ID MYD88_SALSA Reviewed; 283 AA.
AC B3SRQ2;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 48.
DE RecName: Full=Myeloid differentiation primary response protein MyD88;
GN Name=myd88;
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=18602433; DOI=10.1016/j.vaccine.2008.06.054;
RA Strandskog G., Skjaeveland I., Ellingsen T., Jorgensen J.B.;
RT "Double-stranded RNA- and CpG DNA-induced immune responses in Atlantic
RT salmon: comparison and synergies.";
RL Vaccine 26:4704-4715(2008).
CC -!- FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1
CC receptor signaling pathway in the innate immune response.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: The intermediate domain (ID) is required for the
CC phosphorylation and activation of IRAK. {ECO:0000250}.
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DR EMBL; EF672332; ABV59003.1; -; mRNA.
DR RefSeq; NP_001130017.1; NM_001136545.1.
DR STRING; 8030.ENSSSAP00000080060; -.
DR GeneID; 100169859; -.
DR KEGG; sasa:100169859; -.
DR CTD; 4615; -.
DR OrthoDB; 890418at2759; -.
DR Proteomes; UP000087266; Chromosome ssa29.
DR GO; GO:0005815; C:microtubule organizing center; IDA:AgBase.
DR GO; GO:0005634; C:nucleus; IDA:AgBase.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:AgBase.
DR GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR GO; GO:0008134; F:transcription factor binding; IPI:AgBase.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0010629; P:negative regulation of gene expression; IDA:AgBase.
DR GO; GO:0010628; P:positive regulation of gene expression; IDA:AgBase.
DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR CDD; cd08312; Death_MyD88; 1.
DR Gene3D; 1.10.533.10; -; 1.
DR Gene3D; 3.40.50.10140; -; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR034249; MyD88_Death.
DR InterPro; IPR017281; Myelin_different_resp_MyD88.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR15079; PTHR15079; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13676; TIR_2; 1.
DR PIRSF; PIRSF037756; MyD88; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR SUPFAM; SSF52200; SSF52200; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Immunity; Inflammatory response; Innate immunity;
KW Reference proteome.
FT CHAIN 1..283
FT /note="Myeloid differentiation primary response protein
FT MyD88"
FT /id="PRO_0000393143"
FT DOMAIN 22..100
FT /note="Death"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT DOMAIN 146..280
FT /note="TIR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT REGION 101..142
FT /note="Intermediate domain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 283 AA; 32867 MW; 5DF84537A4105406 CRC64;
MSTSLDLWNI PLRALNINVR KRLGLFLNPR NTVASDWMSV AENMGFSYLE IKNYEDCLDP
TRRILEDWQA RCPGAKVGKL LSILDNVDRK DVVEDLRDLI EEDCRRYIER QNEPPLQVPE
VDSCVPKTQE RQGITLEDDP EGGIPELFDA FICYCQSDFD FVHEMXQQLE QTDHKLKLCV
FDRDVLPGSC VWTITSELIE KRCKRMVVVI SDEYLDSDAC DFQTKFALSL CPGARSKRLI
PVKYRSMKKP FPSILRFLTV CDYTRPCTQS WFWVRLARAL SLP
