ID   MYD88_TAKRU             Reviewed;         288 AA.
AC   A8QMS7;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Myeloid differentiation primary response protein MyD88;
GN   Name=myd88;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney;
RA   Matsuo A., Seya T.;
RT   "Function analysis of Fugu rubripes Toll-like receptor21,22.";
RL   Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1
CC       receptor signaling pathway in the innate immune response.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The intermediate domain (ID) is required for the
CC       phosphorylation and activation of IRAK. {ECO:0000250}.
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DR   EMBL; AB197918; BAF91189.1; -; mRNA.
DR   RefSeq; NP_001106666.1; NM_001113195.1.
DR   AlphaFoldDB; A8QMS7; -.
DR   SMR; A8QMS7; -.
DR   STRING; 31033.ENSTRUP00000044800; -.
DR   GeneID; 100134853; -.
DR   KEGG; tru:100134853; -.
DR   CTD; 4615; -.
DR   eggNOG; ENOG502QWKI; Eukaryota.
DR   InParanoid; A8QMS7; -.
DR   OrthoDB; 890418at2759; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR   CDD; cd08312; Death_MyD88; 1.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 3.40.50.10140; -; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR034249; MyD88_Death.
DR   InterPro; IPR017281; Myelin_different_resp_MyD88.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR15079; PTHR15079; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   PIRSF; PIRSF037756; MyD88; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF52200; SSF52200; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Immunity; Inflammatory response; Innate immunity;
KW   Reference proteome.
FT   CHAIN           1..288
FT                   /note="Myeloid differentiation primary response protein
FT                   MyD88"
FT                   /id="PRO_0000393144"
FT   DOMAIN          25..103
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT   DOMAIN          151..285
FT                   /note="TIR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT   REGION          104..148
FT                   /note="Intermediate domain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   288 AA;  33244 MW;  06B1C571116315F8 CRC64;
     MAYCNSKTDL SRVPLLALNM GFRKKVGLYL NPRNAVAADW MALAEALGFT FLEIKNYESA
     INPTVKVLED WQARSTDATV GKLLSILSEV ERNDVLEDLQ PMIDEDVRRY CERLNRDPEP
     PVQVNQVDSC FHRTLERVGL TLHDDPEGTP ELFDAFICYC QRDFEFVQEM IRQLEETDFK
     LKLCVFDRDV LPGSCVWTIT SELIEKRCKR MVVVISDEYL DSEACDFQTK FALSLSPGAR
     NKRLIPVKYK SMSKPFPSIL RFLTLCDYTR PCTQAWFWKR LAKALSLP