ID   MYD88_XENTR             Reviewed;         283 AA.
AC   Q28DJ2;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Myeloid differentiation primary response protein MyD88;
GN   Name=myd88; ORFNames=TNeu124j11.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein involved in the Toll-like receptor and IL-1
CC       receptor signaling pathway in the innate immune response.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The intermediate domain (ID) is required for the
CC       phosphorylation and activation of IRAK. {ECO:0000250}.
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DR   EMBL; CR855486; CAJ83053.1; -; mRNA.
DR   RefSeq; NP_001016837.1; NM_001016837.2.
DR   AlphaFoldDB; Q28DJ2; -.
DR   SMR; Q28DJ2; -.
DR   PaxDb; Q28DJ2; -.
DR   GeneID; 549591; -.
DR   KEGG; xtr:549591; -.
DR   CTD; 4615; -.
DR   Xenbase; XB-GENE-486650; myd88.
DR   eggNOG; ENOG502QWKI; Eukaryota.
DR   InParanoid; Q28DJ2; -.
DR   OrthoDB; 890418at2759; -.
DR   Reactome; R-XTR-1810476; RIP-mediated NFkB activation via ZBP1.
DR   Reactome; R-XTR-209543; p75NTR recruits signalling complexes.
DR   Reactome; R-XTR-3134963; DEx/H-box helicases activate type I IFN and inflammatory cytokines production.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR   GO; GO:0035325; F:Toll-like receptor binding; IBA:GO_Central.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:InterPro.
DR   GO; GO:0008063; P:Toll signaling pathway; IBA:GO_Central.
DR   CDD; cd08312; Death_MyD88; 1.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 3.40.50.10140; -; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR034249; MyD88_Death.
DR   InterPro; IPR017281; Myelin_different_resp_MyD88.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR15079; PTHR15079; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   PIRSF; PIRSF037756; MyD88; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   SUPFAM; SSF52200; SSF52200; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Immunity; Inflammatory response; Innate immunity;
KW   Reference proteome.
FT   CHAIN           1..283
FT                   /note="Myeloid differentiation primary response protein
FT                   MyD88"
FT                   /id="PRO_0000393147"
FT   DOMAIN          27..105
FT                   /note="Death"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00064"
FT   DOMAIN          147..281
FT                   /note="TIR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
FT   REGION          106..143
FT                   /note="Intermediate domain"
FT                   /evidence="ECO:0000250"
FT   REGION          120..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        120..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   283 AA;  32505 MW;  9EC1CF3971384C4A CRC64;
     MACGSSLGSV DMNSIPLVAL NYNVRHRLSL YLNPNAVVAA GWTQLAEEMG YDYLEIKNFE
     RFPDCTMKLL EDWEKKCFRA TVGGLLEMLK KMERNDILTD LGPLIEADCM KHLEKKNAPL
     PLQDDKVDSS EQYRITKSDD PSGSLPETFD AFICYCAQDI SFVQEMISRL EQTDYKLKLC
     VFDRDVLPGT CLWSITSELI EHRCRKMVVI ISDDYLDSSE CDFQTKFALS LGPGAREKRL
     IPVKYKPMKR PFPSILRFIT LCDYTNPCTK GWFWERLAKA LSR