ID   MYDGF_BOVIN             Reviewed;         174 AA.
AC   P62248; Q3T039;
DT   05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Myeloid-derived growth factor {ECO:0000250|UniProtKB:Q969H8};
DE            Short=MYDGF {ECO:0000250|UniProtKB:Q969H8};
DE   Flags: Precursor;
GN   Name=MYDGF {ECO:0000250|UniProtKB:Q969H8};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Bonsdorff T., Gautier M., Olsaker I.;
RT   "Extended sequence analysis of the bovine genes represented by the pBTCL3-
RT   11 clones.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bone marrow-derived monocyte and paracrine-acting protein
CC       that promotes cardiac myocyte survival and adaptive angiogenesis for
CC       cardiac protection and/or repair after myocardial infarction (MI).
CC       Stimulates endothelial cell proliferation through a MAPK1/3-,
CC       STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte
CC       apoptosis in a PI3K/AKT-dependent signaling pathway.
CC       {ECO:0000250|UniProtKB:Q9CPT4}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q969H8}.
CC       Endoplasmic reticulum-Golgi intermediate compartment
CC       {ECO:0000250|UniProtKB:Q969H8}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q969H8}. Golgi apparatus
CC       {ECO:0000250|UniProtKB:Q969H8}. Note=The C-terminal RTEL motif may
CC       provide retention in the endoplasmic reticulum.
CC       {ECO:0000250|UniProtKB:Q969H8}.
CC   -!- SIMILARITY: Belongs to the MYDGF family. {ECO:0000305}.
CC   -!- CAUTION: Human MYDGF has been reported to be secreted into blood plasma
CC       and localized to the endoplasmic reticulum-Golgi intermediate
CC       compartment. However, another report shows resident localization to the
CC       endoplasmic reticulum and Golgi apparatus and secretion when the two
CC       most C-terminal residues of the RTEL motif are abolished.
CC       {ECO:0000250|UniProtKB:Q969H8}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY581200; AAS93436.1; -; mRNA.
DR   EMBL; BC102581; AAI02582.1; -; mRNA.
DR   RefSeq; NP_001001164.1; NM_001001164.1.
DR   AlphaFoldDB; P62248; -.
DR   SMR; P62248; -.
DR   STRING; 9913.ENSBTAP00000024823; -.
DR   PaxDb; P62248; -.
DR   PRIDE; P62248; -.
DR   Ensembl; ENSBTAT00000024823; ENSBTAP00000024823; ENSBTAG00000018655.
DR   GeneID; 407769; -.
DR   KEGG; bta:407769; -.
DR   CTD; 56005; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018655; -.
DR   VGNC; VGNC:31790; MYDGF.
DR   eggNOG; ENOG502RZK9; Eukaryota.
DR   GeneTree; ENSGT00390000000777; -.
DR   HOGENOM; CLU_132160_0_0_1; -.
DR   InParanoid; P62248; -.
DR   OMA; TKIEYAN; -.
DR   OrthoDB; 1577767at2759; -.
DR   TreeFam; TF332795; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000018655; Expressed in granulosa cell and 109 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.
DR   GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; ISS:UniProtKB.
DR   GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
DR   GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISS:UniProtKB.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   InterPro; IPR018887; MYDGF.
DR   PANTHER; PTHR31230; PTHR31230; 1.
DR   Pfam; PF10572; UPF0556; 1.
PE   2: Evidence at transcript level;
KW   Angiogenesis; Apoptosis; Endoplasmic reticulum; Golgi apparatus;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000250|UniProtKB:Q969H8"
FT   CHAIN           33..174
FT                   /note="Myeloid-derived growth factor"
FT                   /id="PRO_0000021007"
SQ   SEQUENCE   174 AA;  19030 MW;  BD7A0A99E153C506 CRC64;
     MAAPSGRRNG SGGANLWVSL LLAAAALRPV ETVSEPTTVA FDVRPGGVVH SFSQNVGPGD
     KYTCVFTYAS QGGTNEKWQM SLGTSEDHQH FTCTIWRPQG KSYLYFTQFK AEVRGAEIEY
     GMAYSKAAFE KESDVPLKNE EFEVTKTAVF HRPGAFKAEL SKLVIVAKAT RSEL