MYDGF_MOUSE
ID MYDGF_MOUSE Reviewed; 166 AA.
AC Q9CPT4; A2RSI7; Q3UG74;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Myeloid-derived growth factor {ECO:0000303|PubMed:25581518};
DE Short=MYDGF {ECO:0000303|PubMed:25581518};
DE Flags: Precursor;
GN Name=Mydgf {ECO:0000303|PubMed:25581518};
GN Synonyms=D17Wsu104e {ECO:0000312|MGI:MGI:2156020};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Embryo, Hypothalamus, Small intestine, Stomach, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP RETRACTED PAPER.
RC TISSUE=Bone marrow;
RX PubMed=11714798; DOI=10.4049/jimmunol.167.11.6338;
RA Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H.,
RA Kitamura T.;
RT "SF20/IL-25, a novel bone marrow stroma-derived growth factor that binds to
RT mouse thymic shared antigen-1 and supports lymphoid cell proliferation.";
RL J. Immunol. 167:6338-6347(2001).
RN [4]
RP RETRACTION NOTICE OF PUBMED:11714798.
RX PubMed=12538725; DOI=10.4049/jimmunol.170.3.1593;
RA Tulin E.E., Onoda N., Nakata Y., Maeda M., Hasegawa M., Nomura H.,
RA Kitamura T.;
RL J. Immunol. 170:1593-1593(2003).
RN [5]
RP SUBCELLULAR LOCATION, INDUCTION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=15378209; DOI=10.1007/s00018-004-4256-z;
RA Wang P., Mariman E., Keijer J., Bouwman F., Noben J.P., Robben J.,
RA Renes J.;
RT "Profiling of the secreted proteins during 3T3-L1 adipocyte differentiation
RT leads to the identification of novel adipokines.";
RL Cell. Mol. Life Sci. 61:2405-2417(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [7]
RP FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE, AND TISSUE
RP SPECIFICITY.
RX PubMed=25581518; DOI=10.1038/nm.3778;
RA Korf-Klingebiel M., Reboll M.R., Klede S., Brod T., Pich A., Polten F.,
RA Napp L.C., Bauersachs J., Ganser A., Brinkmann E., Reimann I., Kempf T.,
RA Niessen H.W., Mizrahi J., Schoenfeld H.J., Iglesias A., Bobadilla M.,
RA Wang Y., Wollert K.C.;
RT "Myeloid-derived growth factor (C19orf10) mediates cardiac repair following
RT myocardial infarction.";
RL Nat. Med. 21:140-149(2015).
CC -!- FUNCTION: Bone marrow-derived monocyte and paracrine-acting protein
CC that promotes cardiac myocyte survival and adaptive angiogenesis for
CC cardiac protection and/or repair after myocardial infarction (MI).
CC Stimulates endothelial cell proliferation through a MAPK1/3-,
CC STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte
CC apoptosis in a PI3K/AKT-dependent signaling pathway.
CC {ECO:0000269|PubMed:25581518}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15378209,
CC ECO:0000269|PubMed:25581518}. Endoplasmic reticulum-Golgi intermediate
CC compartment {ECO:0000250|UniProtKB:Q969H8}. Endoplasmic reticulum
CC {ECO:0000250|UniProtKB:Q969H8}. Golgi apparatus
CC {ECO:0000250|UniProtKB:Q969H8}. Note=The C-terminal RTEL motif may
CC provide retention in the endoplasmic reticulum.
CC {ECO:0000250|UniProtKB:Q969H8}.
CC -!- TISSUE SPECIFICITY: Expressed in prostate, spleen and lung, and weakly
CC expressed in the left ventricle (LF) and liver. Expressed predominantly
CC in inflammatory cells, such as monocytes and macrophages, and weakly
CC expressed in neutrophils, T-cells, B-cells, endothelial cells and
CC cardiac myocytes, after myocardial infarction (MI) (at protein level).
CC {ECO:0000269|PubMed:25581518}.
CC -!- INDUCTION: Up-regulated by ischemia/hypoxia and reperfusion (IR) injury
CC in the left ventricle (at protein level) (PubMed:25581518). Up-
CC regulated during adipocyte differentiation (at protein level)
CC (PubMed:15378209). {ECO:0000269|PubMed:15378209,
CC ECO:0000269|PubMed:25581518}.
CC -!- DISRUPTION PHENOTYPE: Mice show normal postnatal body mass gain,
CC develop normally and are fertile. Show larger infarct collagen-rich
CC scars and more severe heart contractile dysfunction compared to wild-
CC type mice after ischemia and reperfusion (IR) injury.
CC {ECO:0000269|PubMed:25581518}.
CC -!- SIMILARITY: Belongs to the MYDGF family. {ECO:0000305}.
CC -!- CAUTION: Was originally thought to signal lymphoid cells to proliferate
CC via thymic shared antigen 1 (PubMed:11714798). This work was later
CC retracted (PubMed:12538725). {ECO:0000305|PubMed:11714798,
CC ECO:0000305|PubMed:12538725}.
CC -!- CAUTION: It has been reported that MYDGF is secreted into blood plasma
CC (PubMed:15378209, PubMed:25581518). However, another report studying
CC human MYDGF shows resident localization to the endoplasmic reticulum
CC and Golgi apparatus and secretion when the two most C-terminal residues
CC of the RTEL motif are abolished (By similarity).
CC {ECO:0000250|UniProtKB:Q969H8, ECO:0000269|PubMed:15378209,
CC ECO:0000269|PubMed:25581518}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB25931.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY038184; AAK72580.1; -; mRNA.
DR EMBL; AK004074; BAB23155.1; -; mRNA.
DR EMBL; AK008289; BAB25579.1; -; mRNA.
DR EMBL; AK008854; BAB25931.2; ALT_INIT; mRNA.
DR EMBL; AK018016; BAB31038.1; -; mRNA.
DR EMBL; AK133947; BAE21944.1; -; mRNA.
DR EMBL; AK148083; BAE28335.1; -; mRNA.
DR EMBL; AK162834; BAE37074.1; -; mRNA.
DR EMBL; BC132127; AAI32128.1; -; mRNA.
DR EMBL; BC132129; AAI32130.1; -; mRNA.
DR CCDS; CCDS28898.1; -.
DR RefSeq; NP_543027.1; NM_080837.2.
DR AlphaFoldDB; Q9CPT4; -.
DR SMR; Q9CPT4; -.
DR BioGRID; 205767; 4.
DR STRING; 10090.ENSMUSP00000019723; -.
DR PhosphoSitePlus; Q9CPT4; -.
DR REPRODUCTION-2DPAGE; Q9CPT4; -.
DR EPD; Q9CPT4; -.
DR jPOST; Q9CPT4; -.
DR MaxQB; Q9CPT4; -.
DR PaxDb; Q9CPT4; -.
DR PeptideAtlas; Q9CPT4; -.
DR PRIDE; Q9CPT4; -.
DR ProteomicsDB; 287652; -.
DR Antibodypedia; 23698; 241 antibodies from 29 providers.
DR Ensembl; ENSMUST00000019723; ENSMUSP00000019723; ENSMUSG00000019579.
DR GeneID; 28106; -.
DR KEGG; mmu:28106; -.
DR UCSC; uc008dbg.1; mouse.
DR CTD; 56005; -.
DR MGI; MGI:2156020; Mydgf.
DR VEuPathDB; HostDB:ENSMUSG00000019579; -.
DR eggNOG; ENOG502RZK9; Eukaryota.
DR GeneTree; ENSGT00390000000777; -.
DR HOGENOM; CLU_132160_0_0_1; -.
DR InParanoid; Q9CPT4; -.
DR OMA; TKIEYAN; -.
DR OrthoDB; 1577767at2759; -.
DR PhylomeDB; Q9CPT4; -.
DR TreeFam; TF332795; -.
DR BioGRID-ORCS; 28106; 3 hits in 76 CRISPR screens.
DR ChiTaRS; Mydgf; mouse.
DR PRO; PR:Q9CPT4; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9CPT4; protein.
DR Bgee; ENSMUSG00000019579; Expressed in ascending aorta and 263 other tissues.
DR Genevisible; Q9CPT4; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.
DR GO; GO:0045766; P:positive regulation of angiogenesis; IDA:UniProtKB.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:UniProtKB.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB.
DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IDA:UniProtKB.
DR GO; GO:0051897; P:positive regulation of protein kinase B signaling; IDA:UniProtKB.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR InterPro; IPR018887; MYDGF.
DR PANTHER; PTHR31230; PTHR31230; 1.
DR Pfam; PF10572; UPF0556; 1.
PE 1: Evidence at protein level;
KW Angiogenesis; Apoptosis; Endoplasmic reticulum; Golgi apparatus;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000250|UniProtKB:Q969H8"
FT CHAIN 25..166
FT /note="Myeloid-derived growth factor"
FT /id="PRO_0000021009"
SQ SEQUENCE 166 AA; 17982 MW; F95BDC6FC1D44B5B CRC64;
MAAPSGGFWT AVVLAAAALK LAAAVSEPTT VPFDVRPGGV VHSFSQDVGP GNKFTCTFTY
ASQGGTNEQW QMSLGTSEDS QHFTCTIWRP QGKSYLYFTQ FKAELRGAEI EYAMAYSKAA
FERESDVPLK SEEFEVTKTA VSHRPGAFKA ELSKLVIVAK AARSEL
