MYEOV_HUMAN
ID MYEOV_HUMAN Reviewed; 313 AA.
AC Q96EZ4; Q9UGN6; Q9UGN7;
DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Myeloma-overexpressed gene protein;
DE AltName: Full=Oncogene in multiple myeloma;
GN Name=MYEOV; Synonyms=OCIM;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS ALA-159; GLN-198 AND ARG-271.
RC TISSUE=Stomach cancer;
RX PubMed=10753852;
RA Janssen J.W.G., Vaandrager J.W., Heuser T., Jauch A., Kluin P.M.,
RA Geelen E., Bergsagel P.L., Kuehl W.M., Drexler H.G., Otsuki T.,
RA Bartram C.R., Schuuring E.;
RT "Concurrent activation of a novel putative transforming gene, myeov, and
RT cyclin D1 in a subset of multiple myeloma cell lines with
RT t(11;14)(q13;q32).";
RL Blood 95:2691-2698(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-159.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96EZ4; Q15038: DAZAP2; NbExp=3; IntAct=EBI-12260130, EBI-724310;
CC Q96EZ4; Q96CV9: OPTN; NbExp=3; IntAct=EBI-12260130, EBI-748974;
CC Q96EZ4; Q15645: TRIP13; NbExp=3; IntAct=EBI-12260130, EBI-358993;
CC -!- DEVELOPMENTAL STAGE: Overexpressed in tumor cells lines with a
CC t(11;14)(q13;q32) translocation.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB65726.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/MYEOVID395.html";
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DR EMBL; AJ223366; CAB65727.1; -; mRNA.
DR EMBL; AJ223366; CAB65726.1; ALT_INIT; mRNA.
DR EMBL; AP005379; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC011815; AAH11815.1; -; mRNA.
DR CCDS; CCDS8190.1; -.
DR RefSeq; NP_001280220.1; NM_001293291.1.
DR RefSeq; NP_001280223.1; NM_001293294.1.
DR RefSeq; NP_001280225.1; NM_001293296.1.
DR RefSeq; NP_001287852.1; NM_001300923.1.
DR RefSeq; NP_001287853.1; NM_001300924.1.
DR RefSeq; NP_620123.2; NM_138768.3.
DR AlphaFoldDB; Q96EZ4; -.
DR BioGRID; 117748; 16.
DR IntAct; Q96EZ4; 5.
DR STRING; 9606.ENSP00000308330; -.
DR iPTMnet; Q96EZ4; -.
DR PhosphoSitePlus; Q96EZ4; -.
DR BioMuta; MYEOV; -.
DR DMDM; 296439231; -.
DR MassIVE; Q96EZ4; -.
DR PaxDb; Q96EZ4; -.
DR PeptideAtlas; Q96EZ4; -.
DR PRIDE; Q96EZ4; -.
DR Antibodypedia; 2162; 89 antibodies from 23 providers.
DR DNASU; 26579; -.
DR Ensembl; ENST00000308946.3; ENSP00000308330.3; ENSG00000172927.9.
DR Ensembl; ENST00000441339.3; ENSP00000412482.2; ENSG00000172927.9.
DR GeneID; 26579; -.
DR KEGG; hsa:26579; -.
DR MANE-Select; ENST00000441339.3; ENSP00000412482.2; NM_001293291.2; NP_001280220.1.
DR UCSC; uc001oov.3; human.
DR CTD; 26579; -.
DR DisGeNET; 26579; -.
DR GeneCards; MYEOV; -.
DR HGNC; HGNC:7563; MYEOV.
DR HPA; ENSG00000172927; Tissue enhanced (breast, esophagus, stomach).
DR MIM; 605625; gene.
DR neXtProt; NX_Q96EZ4; -.
DR OpenTargets; ENSG00000172927; -.
DR PharmGKB; PA31362; -.
DR VEuPathDB; HostDB:ENSG00000172927; -.
DR eggNOG; ENOG502TE93; Eukaryota.
DR GeneTree; ENSGT00400000022774; -.
DR InParanoid; Q96EZ4; -.
DR OMA; WPGVSTE; -.
DR OrthoDB; 1107210at2759; -.
DR PhylomeDB; Q96EZ4; -.
DR TreeFam; TF353299; -.
DR PathwayCommons; Q96EZ4; -.
DR SignaLink; Q96EZ4; -.
DR BioGRID-ORCS; 26579; 17 hits in 1070 CRISPR screens.
DR ChiTaRS; MYEOV; human.
DR GenomeRNAi; 26579; -.
DR Pharos; Q96EZ4; Tbio.
DR PRO; PR:Q96EZ4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q96EZ4; protein.
DR Bgee; ENSG00000172927; Expressed in lower esophagus mucosa and 112 other tissues.
DR ExpressionAtlas; Q96EZ4; baseline and differential.
DR Genevisible; Q96EZ4; HS.
PE 1: Evidence at protein level;
KW Proto-oncogene; Reference proteome.
FT CHAIN 1..313
FT /note="Myeloma-overexpressed gene protein"
FT /id="PRO_0000096668"
FT REGION 107..129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 159
FT /note="V -> A (in dbSNP:rs7103126)"
FT /evidence="ECO:0000269|PubMed:10753852,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_016603"
FT VARIANT 198
FT /note="R -> Q (in dbSNP:rs11539762)"
FT /evidence="ECO:0000269|PubMed:10753852"
FT /id="VAR_056948"
FT VARIANT 271
FT /note="G -> R (in dbSNP:rs11228610)"
FT /evidence="ECO:0000269|PubMed:10753852"
FT /id="VAR_056949"
FT VARIANT 284
FT /note="P -> T (in dbSNP:rs12274095)"
FT /id="VAR_056950"
FT CONFLICT 219
FT /note="M -> V (in Ref. 3; AAH11815)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 313 AA; 33556 MW; 292ABC0D6AFA52B0 CRC64;
MALRICVTYT PALPIGLCTR CCLCLEQSPS WCHCLRGVSF LTFHLHQSVP LGDRDSLLMF
TRQAGHFVEG SKAGRSRGRL CLSQALRVAV RGAFVSLWFA AGAGDRERNK GDKGAQTGAG
LSQEAEDVDV SRARRVTDAP QGTLCGTGNR NSGSQSARVV GVAHLGEAFR VGVEQAISSC
PEEVHGRHGL SMEIMWARMD VALRSPGRGL LAGAGALCMT LAESSCPDYE RGRRACLTLH
RHPTPHCSTW GLPLRVAGSW LTVVTVEALG GWRMGVRRTG QVGPTMHPPP VSGASPLLLH
HLLLLLLIII LTC
