MYF5_BOVIN
ID MYF5_BOVIN Reviewed; 255 AA.
AC P17667; A6H7F1; Q1T6Y4;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Myogenic factor 5;
DE Short=Myf-5;
GN Name=MYF5;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Fetal muscle;
RX PubMed=2356114; DOI=10.1093/nar/18.11.3147;
RA Clark T.G., Morris J., Akamatsu M., McGraw R.A., Ivarie R.;
RT "A bovine homolog to the human myogenic determination factor myf-5:
RT sequence conservation and 3' processing of transcripts.";
RL Nucleic Acids Res. 18:3147-3153(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=7684719; DOI=10.1016/0378-1119(93)90717-h;
RA Barth J.L., Worrell R.A., Crawford J.M., Morris J., Ivarie R.;
RT "Isolation, sequence, and characterization of the bovine myogenic factor-
RT encoding gene myf-5.";
RL Gene 127:185-191(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Japanese black; TISSUE=Skeletal muscle;
RA Shibata M., Matsumoto K., Aikawa K., Muramoto T., Fujimura S., Kadowaki M.;
RT "Gene expression of MRFs during development of skeletal muscle in Japanese
RT black cattle.";
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Fetal muscle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a transcriptional activator that promotes
CC transcription of muscle-specific target genes and plays a role in
CC muscle differentiation. Together with MYOG and MYOD1, co-occupies
CC muscle-specific gene promoter core region during myogenesis. Induces
CC fibroblasts to differentiate into myoblasts. Probable sequence specific
CC DNA-binding protein (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- SUBCELLULAR LOCATION: Nucleus.
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DR EMBL; X52526; CAA36758.1; -; mRNA.
DR EMBL; M95684; AAA51415.1; -; Genomic_DNA.
DR EMBL; AB257294; BAE93380.1; -; mRNA.
DR EMBL; BC146221; AAI46222.1; -; mRNA.
DR PIR; JN0624; JN0624.
DR RefSeq; NP_776541.1; NM_174116.1.
DR RefSeq; XP_015326365.1; XM_015470879.1.
DR AlphaFoldDB; P17667; -.
DR SMR; P17667; -.
DR STRING; 9913.ENSBTAP00000038425; -.
DR PaxDb; P17667; -.
DR Ensembl; ENSBTAT00000038612; ENSBTAP00000038425; ENSBTAG00000026972.
DR GeneID; 281335; -.
DR KEGG; bta:281335; -.
DR CTD; 4617; -.
DR VEuPathDB; HostDB:ENSBTAG00000026972; -.
DR VGNC; VGNC:31792; MYF5.
DR eggNOG; KOG3960; Eukaryota.
DR GeneTree; ENSGT00950000182959; -.
DR HOGENOM; CLU_066887_1_0_1; -.
DR InParanoid; P17667; -.
DR OMA; MAECNSP; -.
DR OrthoDB; 1471470at2759; -.
DR TreeFam; TF316344; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000026972; Expressed in oocyte and 26 other tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR GO; GO:0001502; P:cartilage condensation; IEA:Ensembl.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0060415; P:muscle tissue morphogenesis; IEA:Ensembl.
DR GO; GO:0001503; P:ossification; IEA:Ensembl.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; IBA:GO_Central.
DR GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; IBA:GO_Central.
DR GO; GO:0001952; P:regulation of cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IBA:GO_Central.
DR GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR022032; Myf5.
DR InterPro; IPR002546; MyoD_N.
DR InterPro; IPR039704; Myogenic_factor.
DR PANTHER; PTHR11534; PTHR11534; 1.
DR Pfam; PF01586; Basic; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF12232; Myf5; 1.
DR SMART; SM00520; BASIC; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding; Myogenesis;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..255
FT /note="Myogenic factor 5"
FT /id="PRO_0000127343"
FT DOMAIN 83..134
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 217..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 255 AA; 28242 MW; 0C7FD41BAE3A04F6 CRC64;
MDMMDGCQFS PSEYFYDGSC IPSPDGEFGD EFEPRVAAFG AHKADLQGSD EDEHVRAPTG
HHQAGHCLMW ACKACKRKST TMDRRKAATM RERRRLKKVN QAFDTLKRCT TTNPNQRLPK
VEILRNAIRY IESLQELLRE QVENYYSLPG QSCSEPTSPT SSCSDGMPEC NSPIWSRKSS
SFDSVYCPDV PNVYATDKSS LSSLDCLSSI VDRITNSEQP GLPLQDPASL SPVASTDSQP
ATPGASSSRL IYHVL
