ID   MYF5_CHICK              Reviewed;         258 AA.
AC   Q08856;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Myogenic factor 5;
DE            Short=Myf-5;
GN   Name=MYF5;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8389445; DOI=10.1093/nar/21.10.2503;
RA   Saitoh O., Fujisawa-Sehara A., Nabeshima Y., Periasamy M.;
RT   "Expression of myogenic factors in denervated chicken breast muscle:
RT   isolation of the chicken Myf5 gene.";
RL   Nucleic Acids Res. 21:2503-2509(1993).
CC   -!- FUNCTION: Acts as a transcriptional activator that promotes
CC       transcription of muscle-specific target genes and plays a role in
CC       muscle differentiation. Induces fibroblasts to differentiate into
CC       myoblasts. Probable sequence specific DNA-binding protein (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; X73250; CAA51712.1; -; Genomic_DNA.
DR   PIR; S41126; S41126.
DR   RefSeq; NP_001025534.1; NM_001030363.1.
DR   AlphaFoldDB; Q08856; -.
DR   SMR; Q08856; -.
DR   STRING; 9031.ENSGALP00000043455; -.
DR   PaxDb; Q08856; -.
DR   GeneID; 395633; -.
DR   KEGG; gga:395633; -.
DR   CTD; 4617; -.
DR   VEuPathDB; HostDB:geneid_395633; -.
DR   eggNOG; KOG3960; Eukaryota.
DR   InParanoid; Q08856; -.
DR   OrthoDB; 1471470at2759; -.
DR   PhylomeDB; Q08856; -.
DR   PRO; PR:Q08856; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IDA:BHF-UCL.
DR   GO; GO:0043425; F:bHLH transcription factor binding; IPI:BHF-UCL.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0042693; P:muscle cell fate commitment; IDA:BHF-UCL.
DR   GO; GO:0045663; P:positive regulation of myoblast differentiation; IBA:GO_Central.
DR   GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0035914; P:skeletal muscle cell differentiation; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR022032; Myf5.
DR   InterPro; IPR002546; MyoD_N.
DR   InterPro; IPR039704; Myogenic_factor.
DR   PANTHER; PTHR11534; PTHR11534; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF12232; Myf5; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   3: Inferred from homology;
KW   Activator; Developmental protein; Differentiation; DNA-binding; Myogenesis;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..258
FT                   /note="Myogenic factor 5"
FT                   /id="PRO_0000127346"
FT   DOMAIN          85..136
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          21..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          220..258
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   258 AA;  28457 MW;  2BCAA9B74997B18D CRC64;
     MEVMDSCQFS PSELFYDSSC LSSPEGEFPE DFEPRELPPF GAPAPTEPAC PEEEEHVRAP
     SGHHQAGHCL MWACKACKRK STTMDRRKAA TMRERRRLKK VNQAFETLKR CTTANPNQRL
     PKVEILRNAI RYIESLQELL REQVENYYHL PGQSCSEPTS PSSSCSDVMA DSRSPVWPAR
     GSSFEAGYCR EMPHGYATEQ SGALSSLDCL SSIVDRLSPA EEPGLPLRHA GSLSPGASID
     SGPGTPGSPP PRRTYQAL