ID   MYF5_COTJA              Reviewed;         246 AA.
AC   P34061;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Myogenic factor 5;
DE            Short=Myf-5;
DE   AltName: Full=Myogenic factor 3;
DE   Flags: Fragment;
GN   Name=MYF5; Synonyms=MF3;
OS   Coturnix japonica (Japanese quail) (Coturnix coturnix japonica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Perdicinae; Coturnix.
OX   NCBI_TaxID=93934;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Muscle;
RX   PubMed=1315698; DOI=10.1016/0012-1606(92)90214-2;
RA   Pownall M.E., Emerson C.P. Jr.;
RT   "Sequential activation of three myogenic regulatory genes during somite
RT   morphogenesis in quail embryos.";
RL   Dev. Biol. 151:67-79(1992).
CC   -!- FUNCTION: Acts as a transcriptional activator that promotes
CC       transcription of muscle-specific target genes and plays a role in
CC       muscle differentiation. Induces fibroblasts to differentiate into
CC       myoblasts. Probable sequence specific DNA-binding protein (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; L15472; AAA49497.1; ALT_TERM; mRNA.
DR   PIR; B43912; B43912.
DR   AlphaFoldDB; P34061; -.
DR   SMR; P34061; -.
DR   Proteomes; UP000694412; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR022032; Myf5.
DR   InterPro; IPR002546; MyoD_N.
DR   InterPro; IPR039704; Myogenic_factor.
DR   PANTHER; PTHR11534; PTHR11534; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF12232; Myf5; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding; Myogenesis;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           <1..246
FT                   /note="Myogenic factor 5"
FT                   /id="PRO_0000127347"
FT   DOMAIN          73..124
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   246 AA;  26999 MW;  0695920DFFC08F0A CRC64;
     RVRARIPGLS SPEGEFPEDF EPRELPPFGA PAPTEPACPE EEEHIRAPSG HHQAGHCLMW
     ACKACKRKST TMDRRKAATM RERRRLKKVN QAFETLKRCT TANPNQRLPK VEILRNAIRY
     IESLQELLRE QVENYYHLPG QSCSEPTSPS SSCSDAMGRT AAGPVWPARG SSFEAGYCPE
     MPHAYATEQS GALSSLDCLS RIVDRLSPAE EPGLPLRHAG SLSPGASIDS GARTPGSPPP
     RTYQAL