ID   MYF5_NOTVI              Reviewed;         256 AA.
AC   Q91154;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Myogenic factor 5;
DE            Short=Myf-5;
GN   Name=MYF-5;
OS   Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Salamandridae; Pleurodelinae;
OC   Notophthalmus.
OX   NCBI_TaxID=8316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Regenerating limb blastema;
RX   PubMed=7703517; DOI=10.1002/aja.1002020102;
RA   Simon H.G., Nelson C., Goff D., Laufer E., Morgan B.A., Tabin C.;
RT   "Differential expression of myogenic regulatory genes and Msx-1 during
RT   dedifferentiation and redifferentiation of regenerating amphibian limbs.";
RL   Dev. Dyn. 202:1-12(1995).
CC   -!- FUNCTION: Acts as a transcriptional activator that promotes
CC       transcription of muscle-specific target genes and plays a role in
CC       muscle differentiation. Induces fibroblasts to differentiate into
CC       myoblasts. Probable sequence specific DNA-binding protein (By
CC       similarity). Plays a role in limb regeneration. {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; X82838; CAA58045.1; -; mRNA.
DR   AlphaFoldDB; Q91154; -.
DR   SMR; Q91154; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR022032; Myf5.
DR   InterPro; IPR002546; MyoD_N.
DR   InterPro; IPR039704; Myogenic_factor.
DR   PANTHER; PTHR11534; PTHR11534; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF12232; Myf5; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding; Myogenesis;
KW   Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..256
FT                   /note="Myogenic factor 5"
FT                   /id="PRO_0000127348"
FT   DOMAIN          83..134
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          218..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..243
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   256 AA;  28834 MW;  3F77DDA8DD8B205F CRC64;
     MDLVDSCQFS PSEFFYDSSS MPSPDDDFVE DFDSRLGRFR VHPDELQCSD EEEHVRAPSG
     HHQAGHCLLW ACKACKRKSS TMDRRKAATM RERRRLKKVN SAFETLKRCT TANPNQRLPK
     VEILRNAISY IESLQELLRE QVENYYTLPG QRCSEPGSPL SNCSDGMAEC NSPAWSRRNG
     SFDSAYCSDI PTMYPTDKLS TLSSLDCLSS IVDRISSPEE PALPQQDNLT LSPSSSLESQ
     LGTPDTPDPR PIYHVL