ID   MYF5_XENLA              Reviewed;         255 AA.
AC   P24700;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Myogenic factor 5;
DE            Short=Myf-5;
GN   Name=myf5;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1716555; DOI=10.1242/dev.111.2.551;
RA   Hopwood N.D., Pluck A., Gurdon J.B.;
RT   "Xenopus Myf-5 marks early muscle cells and can activate muscle genes
RT   ectopically in early embryos.";
RL   Development 111:551-560(1991).
CC   -!- FUNCTION: Acts as a transcriptional activator that promotes
CC       transcription of muscle-specific target genes and plays a role in
CC       muscle differentiation. Induces fibroblasts to differentiate into
CC       myoblasts. Probable sequence specific DNA-binding protein (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; X56738; CAA40062.1; -; mRNA.
DR   PIR; S16151; S16151.
DR   RefSeq; NP_001095249.1; NM_001101779.2.
DR   AlphaFoldDB; P24700; -.
DR   SMR; P24700; -.
DR   GeneID; 397960; -.
DR   KEGG; xla:397960; -.
DR   CTD; 397960; -.
DR   Xenbase; XB-GENE-866267; myf5.L.
DR   OrthoDB; 1471470at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 397960; Expressed in neurula embryo and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR022032; Myf5.
DR   InterPro; IPR002546; MyoD_N.
DR   InterPro; IPR039704; Myogenic_factor.
DR   PANTHER; PTHR11534; PTHR11534; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF12232; Myf5; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding; Myogenesis;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..255
FT                   /note="Myogenic factor 5"
FT                   /id="PRO_0000127349"
FT   DOMAIN          83..134
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          221..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..241
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   255 AA;  28643 MW;  7413CE90DF2566D1 CRC64;
     MEMVDSCHFS PSEFFYDSSC IPSPEEGYTE DYEHGMSIYG AHKKDLEESD EDEHVRAPIG
     HHQAGNCLMW ACKACKRKSS TTDRRKAATM RERRRLKKVN QAFETLKRCT TTNPNQRLPK
     VEILRNAIQY IESLQDLLRE QVENYYSLPG QSCTEPGSPM SSCSDGMSDC SSPQWSGRNS
     SFDNVYCSDL QTSFSSTKLT LSSLDCLSSI VDRISSPQQC SLPIPDSITP SPTSSTDSLP
     RSPDAHDCRP IYHVL