ID   MYF6_BOVIN              Reviewed;         242 AA.
AC   Q7YS80; A5PJL5;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Myogenic factor 6;
DE            Short=Myf-6;
DE   AltName: Full=Muscle-specific regulatory factor 4;
GN   Name=MYF6; Synonyms=MRF4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skeletal muscle;
RA   Muroya S., Nakajima I., Chikuni K.;
RT   "Effect of myogenic regulatory factor siRNAs on differentiation of bovine
RT   skeletal muscle cells.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal muscle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in muscle differentiation (myogenic factor). Induces
CC       fibroblasts to differentiate into myoblasts. Probable sequence specific
CC       DNA-binding protein (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Interacts with CSRP3. {ECO:0000250,
CC       ECO:0000250|UniProtKB:P19335}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; AB110601; BAC76804.1; -; mRNA.
DR   EMBL; BC142159; AAI42160.1; -; mRNA.
DR   RefSeq; NP_861527.1; NM_181811.1.
DR   AlphaFoldDB; Q7YS80; -.
DR   SMR; Q7YS80; -.
DR   STRING; 9913.ENSBTAP00000018607; -.
DR   PaxDb; Q7YS80; -.
DR   PRIDE; Q7YS80; -.
DR   Ensembl; ENSBTAT00000018607; ENSBTAP00000018607; ENSBTAG00000014003.
DR   GeneID; 281336; -.
DR   KEGG; bta:281336; -.
DR   CTD; 4618; -.
DR   VEuPathDB; HostDB:ENSBTAG00000014003; -.
DR   VGNC; VGNC:31793; MYF6.
DR   eggNOG; KOG3960; Eukaryota.
DR   GeneTree; ENSGT00950000182959; -.
DR   HOGENOM; CLU_100258_0_0_1; -.
DR   InParanoid; Q7YS80; -.
DR   OMA; SPCQDQI; -.
DR   OrthoDB; 1471470at2759; -.
DR   TreeFam; TF316344; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000014003; Expressed in gluteus medius and 53 other tissues.
DR   ExpressionAtlas; Q7YS80; baseline.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0045663; P:positive regulation of myoblast differentiation; IBA:GO_Central.
DR   GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0035914; P:skeletal muscle cell differentiation; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR002546; MyoD_N.
DR   InterPro; IPR039704; Myogenic_factor.
DR   PANTHER; PTHR11534; PTHR11534; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Myogenesis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..242
FT                   /note="Myogenic factor 6"
FT                   /id="PRO_0000127350"
FT   DOMAIN          93..144
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          31..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   242 AA;  26976 MW;  0359147B18071020 CRC64;
     MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPP EAGSDSSGEE
     HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL RERRRLKKIN EAFEALKRRT
     VANPNQRLPK VEILRSAINY IERLQDLLHR LDQQDKMQEL GVDPFSYRPK QENLEGADFL
     RTCSSQWPSV SDHSRGLVIT AKEGGTSIDS SASSSLRCLS SIVDSISSEE HKLPCVEEVV
     EK