ID   MYF6_CHICK              Reviewed;         242 AA.
AC   Q01795;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Myogenic factor 6;
DE            Short=Myf-6;
DE   AltName: Full=Muscle-specific regulatory factor 4;
GN   Name=MYF6; Synonyms=MRF4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1374396; DOI=10.1016/s0021-9258(19)50195-8;
RA   Fujisawa-Sehara A., Nabeshima Y., Komiya T., Uetsuki T., Asakura A.,
RA   Nabeshima Y.;
RT   "Differential trans-activation of muscle-specific regulatory elements
RT   including the mysosin light chain box by chicken MyoD, myogenin, and
RT   MRF4.";
RL   J. Biol. Chem. 267:10031-10038(1992).
CC   -!- FUNCTION: Involved in muscle differentiation (myogenic factor). Induces
CC       fibroblasts to differentiate into myoblasts. Probable sequence specific
CC       DNA-binding protein.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Skeletal muscle.
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DR   EMBL; D10599; BAA01450.1; -; mRNA.
DR   PIR; A42668; A42668.
DR   RefSeq; NP_001025917.1; NM_001030746.1.
DR   RefSeq; XP_015137402.1; XM_015281916.1.
DR   AlphaFoldDB; Q01795; -.
DR   SMR; Q01795; -.
DR   STRING; 9031.ENSGALP00000030023; -.
DR   Ensembl; ENSGALT00000030660; ENSGALP00000030023; ENSGALG00000010936.
DR   GeneID; 417873; -.
DR   KEGG; gga:417873; -.
DR   CTD; 4618; -.
DR   VEuPathDB; HostDB:geneid_417873; -.
DR   eggNOG; KOG3960; Eukaryota.
DR   GeneTree; ENSGT00950000182959; -.
DR   HOGENOM; CLU_100258_0_0_1; -.
DR   InParanoid; Q01795; -.
DR   OMA; SPCQDQI; -.
DR   OrthoDB; 1471470at2759; -.
DR   PhylomeDB; Q01795; -.
DR   PRO; PR:Q01795; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000010936; Expressed in muscle tissue and 4 other tissues.
DR   ExpressionAtlas; Q01795; baseline.
DR   GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IDA:BHF-UCL.
DR   GO; GO:0043425; F:bHLH transcription factor binding; IPI:BHF-UCL.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0042693; P:muscle cell fate commitment; IDA:BHF-UCL.
DR   GO; GO:0060415; P:muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0045663; P:positive regulation of myoblast differentiation; IBA:GO_Central.
DR   GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0035914; P:skeletal muscle cell differentiation; IBA:GO_Central.
DR   GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR002546; MyoD_N.
DR   InterPro; IPR039704; Myogenic_factor.
DR   PANTHER; PTHR11534; PTHR11534; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Myogenesis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..242
FT                   /note="Myogenic factor 6"
FT                   /id="PRO_0000127355"
FT   DOMAIN          93..144
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          30..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          190..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..52
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   242 AA;  26351 MW;  A2BFF4F3F3B4CD37 CRC64;
     MMMDLFETGS YFFYLDGENG ALQQLEMAEG SPLYPGSDGT LSPCQDQLPP EAGSDSSGEE
     HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL RERRRLKKIN EAFEALKRRT
     VANPNQRLPK VEILRSAISY IERLQDLLHR LDQQDKMQEV AADPFSFSPK QGNVPGSDFL
     STCGSDWHSA SDHSRALGGS PKAGGSMVES SASSSLRCLS SIVDSISSDE PKLPGAEEAV
     EK