MYF6_PIG
ID MYF6_PIG Reviewed; 242 AA.
AC Q3YFL6; Q7YRC4;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Myogenic factor 6;
DE Short=Myf-6;
GN Name=MYF6;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=L990;
RX PubMed=15595701; DOI=10.1081/labt-200038667;
RA Wyszynska-Koko J., Kuryl J.;
RT "Porcine MYF6 gene: sequence, homology analysis, and variation in the
RT promoter region.";
RL Anim. Biotechnol. 15:159-173(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Liu M., Jiang S.W.;
RT "Associations of polymorphisms in the genes of MYF5, MYOD1 and MYF6 with
RT meat quality and carcass traits in pig.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in muscle differentiation (myogenic factor). Induces
CC fibroblasts to differentiate into myoblasts. Probable sequence specific
CC DNA-binding protein (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY327443; AAQ16205.1; -; Genomic_DNA.
DR EMBL; DQ139775; AAZ73770.1; -; Genomic_DNA.
DR RefSeq; NP_001231601.1; NM_001244672.1.
DR AlphaFoldDB; Q3YFL6; -.
DR SMR; Q3YFL6; -.
DR STRING; 9823.ENSSSCP00000001001; -.
DR PaxDb; Q3YFL6; -.
DR PRIDE; Q3YFL6; -.
DR Ensembl; ENSSSCT00000001023; ENSSSCP00000001001; ENSSSCG00000026533.
DR Ensembl; ENSSSCT00005049734; ENSSSCP00005030714; ENSSSCG00005031229.
DR Ensembl; ENSSSCT00015071271; ENSSSCP00015028570; ENSSSCG00015053523.
DR Ensembl; ENSSSCT00025090015; ENSSSCP00025039423; ENSSSCG00025065595.
DR Ensembl; ENSSSCT00030020084; ENSSSCP00030008946; ENSSSCG00030014581.
DR Ensembl; ENSSSCT00035095460; ENSSSCP00035040150; ENSSSCG00035070649.
DR Ensembl; ENSSSCT00040001581; ENSSSCP00040000398; ENSSSCG00040001349.
DR Ensembl; ENSSSCT00045027090; ENSSSCP00045018724; ENSSSCG00045015931.
DR Ensembl; ENSSSCT00050091461; ENSSSCP00050039371; ENSSSCG00050067082.
DR Ensembl; ENSSSCT00055058017; ENSSSCP00055046417; ENSSSCG00055029231.
DR Ensembl; ENSSSCT00060003777; ENSSSCP00060001245; ENSSSCG00060003062.
DR Ensembl; ENSSSCT00065042254; ENSSSCP00065017907; ENSSSCG00065031246.
DR Ensembl; ENSSSCT00070038941; ENSSSCP00070032607; ENSSSCG00070019691.
DR GeneID; 397005; -.
DR KEGG; ssc:397005; -.
DR CTD; 4618; -.
DR VGNC; VGNC:103304; MYF6.
DR eggNOG; KOG3960; Eukaryota.
DR GeneTree; ENSGT00950000182959; -.
DR HOGENOM; CLU_100258_0_0_1; -.
DR InParanoid; Q3YFL6; -.
DR OMA; SPCQDQI; -.
DR OrthoDB; 1471470at2759; -.
DR TreeFam; TF316344; -.
DR Reactome; R-SSC-525793; Myogenesis.
DR Proteomes; UP000008227; Chromosome 5.
DR Proteomes; UP000314985; Chromosome 5.
DR Bgee; ENSSSCG00000026533; Expressed in longissimus lumborum muscle and 9 other tissues.
DR ExpressionAtlas; Q3YFL6; baseline and differential.
DR Genevisible; Q3YFL6; SS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0060415; P:muscle tissue morphogenesis; IEA:Ensembl.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; IBA:GO_Central.
DR GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IBA:GO_Central.
DR GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002546; MyoD_N.
DR InterPro; IPR039704; Myogenic_factor.
DR PANTHER; PTHR11534; PTHR11534; 1.
DR Pfam; PF01586; Basic; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00520; BASIC; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 3: Inferred from homology;
KW Developmental protein; Differentiation; DNA-binding; Myogenesis; Nucleus;
KW Reference proteome.
FT CHAIN 1..242
FT /note="Myogenic factor 6"
FT /id="PRO_0000127353"
FT DOMAIN 93..144
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 31..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 240
FT /note="G -> V (in Ref. 1; AAQ16205)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 242 AA; 26952 MW; 0359167DB31DB420 CRC64;
MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPP EAGSDSSGEE
HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL RERRRLKKIN EAFEALKRRT
VANPNQRLPK VEILRSAINY IERLQDLLHR LDQQDKMQEL GVDPFSYRPK QENLEGADFL
RTCSSQWPSV SDHSRGLVMT AKEGGTNIDS SASSSLRCLS SIVDSISSEE HTLPCVEEVG
EK
