MYF6_RAT
ID MYF6_RAT Reviewed; 242 AA.
AC P19335;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Myogenic factor 6;
DE Short=Myf-6;
DE AltName: Full=Muscle-specific regulatory factor 4;
GN Name=Myf6; Synonyms=Mrf4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Soleus muscle;
RX PubMed=2560751; DOI=10.1101/gad.3.12b.2050;
RA Rhodes S.J., Konieczny S.F.;
RT "Identification of MRF4: a new member of the muscle regulatory factor gene
RT family.";
RL Genes Dev. 3:2050-2061(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=1639267; DOI=10.1016/0378-1119(92)90730-d;
RA Hinterberger T.J., Mays J.L., Konieczny S.F.;
RT "Structure and myofiber-specific expression of the rat muscle regulatory
RT gene MRF4.";
RL Gene 117:201-207(1992).
RN [3]
RP INTERACTION WITH CSRP3.
RX PubMed=9234731; DOI=10.1128/mcb.17.8.4750;
RA Kong Y., Flick M.J., Kudla A.J., Konieczny S.F.;
RT "Muscle LIM protein promotes myogenesis by enhancing the activity of
RT MyoD.";
RL Mol. Cell. Biol. 17:4750-4760(1997).
CC -!- FUNCTION: Involved in muscle differentiation (myogenic factor). Induces
CC fibroblasts to differentiate into myoblasts. Probable sequence specific
CC DNA-binding protein. May play a role in controlling terminal
CC differentiation events.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. Interacts with CSRP3. {ECO:0000269|PubMed:9234731}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Skeletal muscle in late fetal and adult rats.
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DR EMBL; M27151; AAA41636.1; -; mRNA.
DR EMBL; M84685; AAA41635.1; -; Genomic_DNA.
DR PIR; JC1233; JC1233.
DR RefSeq; NP_037304.1; NM_013172.2.
DR AlphaFoldDB; P19335; -.
DR SMR; P19335; -.
DR DIP; DIP-485N; -.
DR IntAct; P19335; 1.
DR STRING; 10116.ENSRNOP00000006523; -.
DR iPTMnet; P19335; -.
DR PhosphoSitePlus; P19335; -.
DR PaxDb; P19335; -.
DR Ensembl; ENSRNOT00000006523; ENSRNOP00000006523; ENSRNOG00000004878.
DR GeneID; 25714; -.
DR KEGG; rno:25714; -.
DR UCSC; RGD:3134; rat.
DR CTD; 4618; -.
DR RGD; 3134; Myf6.
DR eggNOG; KOG3960; Eukaryota.
DR GeneTree; ENSGT00950000182959; -.
DR HOGENOM; CLU_100258_0_0_1; -.
DR InParanoid; P19335; -.
DR OMA; SPCQDQI; -.
DR OrthoDB; 1471470at2759; -.
DR PhylomeDB; P19335; -.
DR TreeFam; TF316344; -.
DR Reactome; R-RNO-525793; Myogenesis.
DR PRO; PR:P19335; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000004878; Expressed in skeletal muscle tissue and 3 other tissues.
DR Genevisible; P19335; RN.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0060415; P:muscle tissue morphogenesis; ISO:RGD.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; IBA:GO_Central.
DR GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; ISO:RGD.
DR GO; GO:0007519; P:skeletal muscle tissue development; ISO:RGD.
DR GO; GO:0043403; P:skeletal muscle tissue regeneration; IMP:RGD.
DR GO; GO:0001756; P:somitogenesis; ISO:RGD.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002546; MyoD_N.
DR InterPro; IPR039704; Myogenic_factor.
DR PANTHER; PTHR11534; PTHR11534; 1.
DR Pfam; PF01586; Basic; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00520; BASIC; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Myogenesis; Nucleus;
KW Reference proteome.
FT CHAIN 1..242
FT /note="Myogenic factor 6"
FT /id="PRO_0000127354"
FT DOMAIN 93..144
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 31..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 242 AA; 26987 MW; 4EFD739BB6C4F6C5 CRC64;
MMMDLFETGS YFFYLDGENV TLQPLEVAEG SPLYPGSDGT LSPCQDQMPQ EAGSDSSGEE
HVLAPPGLQP PHCPGQCLIW ACKTCKRKSA PTDRRKAATL RERRRLKKIN EAFEALKRRT
VANPNQRLPK VEILRSAINY IERLQDLLHR LDQQEKMQEL GVDPYSYKPK QEILEGADFL
RTCSPQWPSV SDHSRGLVIT AKEGGASVDA SASSSLQRLS SIVDSISSEE RKLPSVEEVV
EK
