ID   MYF6_TAKRU              Reviewed;         239 AA.
AC   Q6SYV5; Q90ZL0;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Myogenic factor 6;
DE            Short=Myf-6;
DE   AltName: Full=Muscle-specific regulatory factor 4;
GN   Name=myf6; Synonyms=mrf4;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Fernandes J.M., Mackenzie M.G., Kinghorn J.R., Johnston I.A.;
RT   "Myf6 cDNA from Fugu rubripes.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Coutelle O., Summerbell D., Halai C., Sydney B., Rigby P.W.;
RT   "Cross species transgenics show different interpretation of transcription
RT   factor signals in mouse and Fugu myf5.";
RL   Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in muscle differentiation (myogenic factor). Induces
CC       fibroblasts to differentiate into myoblasts. Probable sequence specific
CC       DNA-binding protein (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; AY445320; AAR20812.1; -; mRNA.
DR   EMBL; AJ308546; CAC39207.1; -; Genomic_DNA.
DR   RefSeq; NP_001027943.1; NM_001032771.1.
DR   AlphaFoldDB; Q6SYV5; -.
DR   SMR; Q6SYV5; -.
DR   STRING; 31033.ENSTRUP00000027392; -.
DR   GeneID; 446039; -.
DR   KEGG; tru:446039; -.
DR   CTD; 4618; -.
DR   eggNOG; KOG3960; Eukaryota.
DR   InParanoid; Q6SYV5; -.
DR   OrthoDB; 1471470at2759; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR002546; MyoD_N.
DR   InterPro; IPR039704; Myogenic_factor.
DR   PANTHER; PTHR11534; PTHR11534; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Myogenesis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..239
FT                   /note="Myogenic factor 6"
FT                   /id="PRO_0000127357"
FT   DOMAIN          96..147
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          28..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..189
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        161..179
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        16
FT                   /note="R -> G (in Ref. 2; CAC39207)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        43
FT                   /note="S -> R (in Ref. 2; CAC39207)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        179
FT                   /note="G -> V (in Ref. 2; CAC39207)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        239
FT                   /note="D -> N (in Ref. 2; CAC39207)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   239 AA;  26694 MW;  7AB2333774279835 CRC64;
     MMDLFETNTY LFNDLRYLEE GDHGPLQHLD MSGVSPLYNG NDSPLSPGQD NVPSETGGES
     SGDEHVLAPP GLRSHCEGQC LMWACKICKR KSAPTDRRKA ATLRERRRLK KINEAFDALK
     RKTVANPNQR LPKVEILRSA ISYIERLQDL LQTLDEQERS QSGASDTRND KEQNRPSGGD
     YRWKKASNTW PTSADHSAII NQRDGNCESS ATSSLLCLSS IVSSISDDKT NLRQGVQED