MYF6_TETNG
ID MYF6_TETNG Reviewed; 239 AA.
AC Q6PUV5; Q4SAB2;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Myogenic factor 6;
DE Short=Myf-6;
DE AltName: Full=Muscle-specific regulatory factor 4;
GN Name=myf6; Synonyms=mrf4; ORFNames=GSTENG00021536001;
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA MacKenzie M.G., Fernandes J.M.O., Johnston I.A., Kinghorn J.R.;
RT "Tetraodon nigroviridis myogenic regulatory factor 4 mRNA.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
CC -!- FUNCTION: Involved in muscle differentiation (myogenic factor). Induces
CC fibroblasts to differentiate into myoblasts. Probable sequence specific
CC DNA-binding protein (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAG02420.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY576806; AAS88438.1; -; mRNA.
DR EMBL; CAAE01014691; CAG02420.1; ALT_SEQ; Genomic_DNA.
DR AlphaFoldDB; Q6PUV5; -.
DR SMR; Q6PUV5; -.
DR STRING; 99883.ENSTNIP00000014352; -.
DR KEGG; tng:GSTEN00021536G001; -.
DR InParanoid; Q6PUV5; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002546; MyoD_N.
DR InterPro; IPR039704; Myogenic_factor.
DR PANTHER; PTHR11534; PTHR11534; 1.
DR Pfam; PF01586; Basic; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00520; BASIC; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Myogenesis; Nucleus;
KW Reference proteome.
FT CHAIN 1..239
FT /note="Myogenic factor 6"
FT /id="PRO_0000127358"
FT DOMAIN 96..147
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 27..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 32
FT /note="P -> S (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 39
FT /note="D -> N (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 42
FT /note="H -> D (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 49
FT /note="P -> Q (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 74
FT /note="A -> S (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="L -> H (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 87
FT /note="V -> I (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 123
FT /note="S -> T (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="E -> A (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 149
FT /note="E -> D (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 153
FT /note="S -> T (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="C -> R (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 188
FT /note="E -> N (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 206
FT /note="A -> N (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 212
FT /note="S -> T (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
FT CONFLICT 230..231
FT /note="TD -> AN (in Ref. 1; AAS88438)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 239 AA; 26527 MW; FD5CB9D414F7A90C CRC64;
MMDLFETNTY LFNDLRYLEE GDHGPLQHLD MPGVSPLYDG NHSPLSPGPD NVPSETGGES
SGDEHVLAPP GLRAHCEGQC LMWACKVCKR KSAPTDRRKA ATLRERRRLK KINEAFDALK
RKSVANPNQR LPKVEILRSA ISYIERLQEL LQSLDEQERG QSGASDTRND KEQNRPSGGD
YCWKKASETW PTSADHSAII NQRDGACESS ASSSLLCLSS IVSSISDDKT DLRQGVQED
