ID   MYF6_XENLA              Reviewed;         240 AA.
AC   Q92020; Q1X7U4;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Myogenic factor 6;
DE            Short=Myf-6;
DE   AltName: Full=Muscle-specific regulatory factor 4;
GN   Name=myf6; Synonyms=mrf4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=1374354;
RA   Jennings C.G.B.;
RT   "Expression of the myogenic gene MRF4 during Xenopus development.";
RL   Dev. Biol. 150:121-132(1992).
RN   [2]
RP   ERRATUM OF PUBMED:1374354.
RA   Jennings C.G.B.;
RL   Dev. Biol. 151:319-332(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16258964; DOI=10.1002/dvdy.20628;
RA   Della Gaspera B., Sequeira I., Charbonnier F., Becker C., Shi D.L.,
RA   Chanoine C.;
RT   "Spatio-temporal expression of MRF4 transcripts and protein during Xenopus
RT   laevis embryogenesis.";
RL   Dev. Dyn. 235:524-529(2006).
CC   -!- FUNCTION: Involved in muscle differentiation (myogenic factor). Induces
CC       fibroblasts to differentiate into myoblasts. Probable sequence specific
CC       DNA-binding protein (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- TISSUE SPECIFICITY: Skeletal muscle. {ECO:0000269|PubMed:1374354}.
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DR   EMBL; S84990; AAB21581.1; -; mRNA.
DR   EMBL; S34392; AAB22140.1; -; mRNA.
DR   EMBL; AY970827; AAY40356.1; -; mRNA.
DR   PIR; B44886; B43909.
DR   RefSeq; NP_001081477.1; NM_001088008.1.
DR   AlphaFoldDB; Q92020; -.
DR   SMR; Q92020; -.
DR   GeneID; 397858; -.
DR   KEGG; xla:397858; -.
DR   CTD; 397858; -.
DR   Xenbase; XB-GENE-6252334; myf6.L.
DR   OrthoDB; 1471470at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 397858; Expressed in muscle tissue and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR002546; MyoD_N.
DR   InterPro; IPR039704; Myogenic_factor.
DR   PANTHER; PTHR11534; PTHR11534; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Myogenesis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..240
FT                   /note="Myogenic factor 6"
FT                   /id="PRO_0000127359"
FT   DOMAIN          91..142
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
SQ   SEQUENCE   240 AA;  27127 MW;  5DFBA77410768367 CRC64;
     MMDLFETNSY FFYLDGDNGA FQQLGVADGS PVYPGSEGTL SPCRDQLPVD AGSDRSEEEH
     VLAPPGLQPH CPGQCLIWAC KTCKRKSAPT DRRKAATLRE RRRLKKINEA FEALKRRTVA
     NPNQRLPKVE ILRSAINYIE RLQDLLHSLD QQDKPQKADE EPFSYNSKEA PVQSEDFLST
     CHPEWHHIPD HSRMPNLNIK EEGSLQENSS SSLQCLSSIV DSISSDEPRH PCTIQELVEN