ID   MYG1_BOVIN              Reviewed;         381 AA.
AC   Q58DG1;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=MYG1 exonuclease {ECO:0000305};
DE            EC=3.1.-.- {ECO:0000250|UniProtKB:Q9HB07};
DE   Flags: Precursor;
GN   Name=MYG1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: 3'-5' RNA exonuclease which cleaves in situ on specific
CC       transcripts in both nucleus and mitochondrion. Involved in regulating
CC       spatially segregated organellar RNA processing, acts as a coordinator
CC       of nucleo-mitochondrial crosstalk. In nucleolus, processes pre-
CC       ribosomal RNA involved in ribosome assembly and alters cytoplasmic
CC       translation. In mitochondrial matrix, processes 3'-termini of the mito-
CC       ribosomal and messenger RNAs and controls translation of mitochondrial
CC       proteins. {ECO:0000250|UniProtKB:Q9HB07}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q9HB07}. Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:Q9HB07}. Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9JK81}.
CC   -!- SIMILARITY: Belongs to the MYG1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BT021616; AAX46463.1; -; mRNA.
DR   EMBL; BT021636; AAX46483.1; -; mRNA.
DR   EMBL; BC111153; AAI11154.1; -; mRNA.
DR   AlphaFoldDB; Q58DG1; -.
DR   STRING; 9913.ENSBTAP00000026875; -.
DR   PaxDb; Q58DG1; -.
DR   PRIDE; Q58DG1; -.
DR   Ensembl; ENSBTAT00000026875; ENSBTAP00000026875; ENSBTAG00000020177.
DR   VEuPathDB; HostDB:ENSBTAG00000020177; -.
DR   VGNC; VGNC:49159; MYG1.
DR   eggNOG; KOG2948; Eukaryota.
DR   GeneTree; ENSGT00390000010265; -.
DR   HOGENOM; CLU_051576_0_0_1; -.
DR   InParanoid; Q58DG1; -.
DR   OMA; FHCDEVV; -.
DR   TreeFam; TF313313; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000020177; Expressed in laryngeal cartilage and 106 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0035641; P:locomotory exploration behavior; IEA:Ensembl.
DR   InterPro; IPR003226; Met-dep_prot_hydro.
DR   PANTHER; PTHR11215; PTHR11215; 1.
DR   Pfam; PF03690; UPF0160; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Hydrolase; Mitochondrion; Nuclease; Nucleus; Phosphoprotein;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..47
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           48..381
FT                   /note="MYG1 exonuclease"
FT                   /id="PRO_0000245579"
FT   MOD_RES         120
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HB07"
FT   MOD_RES         267
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HB07"
FT   MOD_RES         273
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JK81"
SQ   SEQUENCE   381 AA;  42967 MW;  7CCA40DE4CCC30D0 CRC64;
     MGHRFLRGFL RVLLPPLPLR SPHLKLSLEP VAPSKRPRSH LMAPPRIGTH NGTFHCDEAL
     ACALLRLLPE YREAEIVRTR DPEKLAACDI VVDVGGEYDP QRHRYDHHQR SFTETMSSLS
     PGKPWQTKLS SAGLIYLHFG HKLLAQLLGT SEEDGMVGTL YDKMYENFVE EVDAVDNGIS
     QWEEGEPRYL LTTTLSARVA RLNPTWNQPN QDTEAGFKRA MDLVREEFLQ RLDFYQNSWL
     PARTLVEEAL AKRFQVDPSG EIIELEKGGC PWKEHLYQLE LGLSPAGTIA FVIYTDQAGQ
     WRVQCVPKEP HSFQSRLPLL EPWRGLRDEA LDQISGIPGC IFVHASGFIG GHRTREGALS
     MARATLAQRP APTPAPNPMV Q