ID   MYG1_RAT                Reviewed;         381 AA.
AC   Q641W2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=MYG1 exonuclease;
DE            EC=3.1.-.- {ECO:0000250|UniProtKB:Q9HB07};
DE   Flags: Precursor;
GN   Name=Myg1 {ECO:0000312|EMBL:AAH82112.1, ECO:0000312|RGD:1359237};
GN   Synonyms=C12orf10 {ECO:0000312|RGD:1359237};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:EDL86845.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000312|EMBL:EDL86845.1};
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:AAH82112.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Brown Norway {ECO:0000269|PubMed:15489334};
RC   TISSUE=Testis {ECO:0000312|EMBL:AAH82112.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:EDL86845.1}
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RA   Maurya D.K., Bhargava P.;
RL   Submitted (MAR-2009) to UniProtKB.
CC   -!- FUNCTION: 3'-5' RNA exonuclease which cleaves in situ on specific
CC       transcripts in both nucleus and mitochondrion. Involved in regulating
CC       spatially segregated organellar RNA processing, acts as a coordinator
CC       of nucleo-mitochondrial crosstalk. In nucleolus, processes pre-
CC       ribosomal RNA involved in ribosome assembly and alters cytoplasmic
CC       translation. In mitochondrial matrix, processes 3'-termini of the mito-
CC       ribosomal and messenger RNAs and controls translation of mitochondrial
CC       proteins. {ECO:0000250|UniProtKB:Q9HB07}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q9HB07}. Mitochondrion matrix
CC       {ECO:0000250|UniProtKB:Q9HB07}. Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9JK81}.
CC   -!- SIMILARITY: Belongs to the MYG1 family. {ECO:0000305}.
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DR   EMBL; CH474035; EDL86845.1; -; Genomic_DNA.
DR   EMBL; BC082112; AAH82112.1; -; mRNA.
DR   RefSeq; NP_001005545.1; NM_001005545.1.
DR   AlphaFoldDB; Q641W2; -.
DR   STRING; 10116.ENSRNOP00000017942; -.
DR   iPTMnet; Q641W2; -.
DR   PhosphoSitePlus; Q641W2; -.
DR   jPOST; Q641W2; -.
DR   PaxDb; Q641W2; -.
DR   PRIDE; Q641W2; -.
DR   Ensembl; ENSRNOT00000017942; ENSRNOP00000017942; ENSRNOG00000013343.
DR   GeneID; 300258; -.
DR   KEGG; rno:300258; -.
DR   UCSC; RGD:1359237; rat.
DR   CTD; 60314; -.
DR   RGD; 1359237; Myg1.
DR   eggNOG; KOG2948; Eukaryota.
DR   GeneTree; ENSGT00390000010265; -.
DR   HOGENOM; CLU_051576_0_0_1; -.
DR   InParanoid; Q641W2; -.
DR   OMA; FHCDEVV; -.
DR   OrthoDB; 1174497at2759; -.
DR   PhylomeDB; Q641W2; -.
DR   TreeFam; TF313313; -.
DR   PRO; PR:Q641W2; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Proteomes; UP000234681; Chromosome 7.
DR   Bgee; ENSRNOG00000013343; Expressed in pancreas and 20 other tissues.
DR   Genevisible; Q641W2; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0035641; P:locomotory exploration behavior; ISO:RGD.
DR   InterPro; IPR003226; Met-dep_prot_hydro.
DR   PANTHER; PTHR11215; PTHR11215; 1.
DR   Pfam; PF03690; UPF0160; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Hydrolase; Mitochondrion; Nuclease; Nucleus;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..47
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           48..381
FT                   /note="MYG1 exonuclease"
FT                   /id="PRO_0000371227"
FT   MOD_RES         267
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HB07"
FT   MOD_RES         273
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JK81"
SQ   SEQUENCE   381 AA;  42889 MW;  C05C46F3C28E89BA CRC64;
     MGRGFLRGVL TLLPLRSVLQ VQHCMLVSEP DLPPKRPRNN LMAPPRIGTH NGTFHCDEAL
     ACALLRLLPE YRNAEIVRTR DPEKLALCDI VVDVGGEYNP QRHRYDHHQR TFTETMSSLC
     PGKPWQTKLS SAGLVYLHFG HKLLAQLLGT SEEDSVVDTI YDKMYENFVE EVDAVDNGIS
     QWAEGEPRYA LTTTLSARVS RLNPTWNQPD QDTEAGFRRA MDLVQEEFLQ RLNFYQHSWL
     PARALVEEAL AQRFKVDSSG EIVELAKGGC PWKEHLYHLE SELSPTVAIT FVIYTDQAGQ
     WRVQCVPKEP HSFQSRLPLP EPWRGLRDEA LDQVSGIPGC IFVHASGFIG GHHTREGALN
     MARATLAQRT APVPLANAVV Q