ID   MYG_ELEMA               Reviewed;         154 AA.
AC   P02186;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Myoglobin;
GN   Name=MB;
OS   Elephas maximus (Indian elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Elephas.
OX   NCBI_TaxID=9783;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-154.
RC   TISSUE=Skeletal muscle;
RX   PubMed=6102395; DOI=10.1098/rspb.1980.0016;
RA   Dene H., Goodman M., Romero-Herrera A.E.;
RT   "The amino acid sequence of elephant (Elephas maximus) myoglobin and the
RT   phylogeny of Proboscidea.";
RL   Proc. R. Soc. Lond., B, Biol. Sci. 207:111-127(1980).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS) OF 2-154 IN COMPLEX WITH HEME, AND
RP   SEQUENCE REVISION TO 28 AND 30.
RX   PubMed=7657658; DOI=10.1074/jbc.270.35.20754;
RA   Bisig D.A., di Iorio E.E., Diederichs K., Winterhalter K.H., Piontek K.;
RT   "Crystal structure of Asian elephant (Elephas maximus) cyano-metmyoglobin
RT   at 1.78-A resolution. Phe29(B10) accounts for its unusual ligand binding
RT   properties.";
RL   J. Biol. Chem. 270:20754-20762(1995).
CC   -!- FUNCTION: Serves as a reserve supply of oxygen and facilitates the
CC       movement of oxygen within muscles.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A94228; MYELI.
DR   PDB; 1EMY; X-ray; 1.78 A; A=2-154.
DR   PDBsum; 1EMY; -.
DR   AlphaFoldDB; P02186; -.
DR   SMR; P02186; -.
DR   EvolutionaryTrace; P02186; -.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR002335; Myoglobin.
DR   PANTHER; PTHR47132; PTHR47132; 1.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00613; MYOGLOBIN.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
KW   Muscle protein; Oxygen transport; Phosphoprotein; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:6102395"
FT   CHAIN           2..154
FT                   /note="Myoglobin"
FT                   /id="PRO_0000053290"
FT   BINDING         94
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000269|PubMed:7657658,
FT                   ECO:0007744|PDB:1EMY"
FT   MOD_RES         4
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QZ76"
FT   MOD_RES         68
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P04247"
FT   CONFLICT        28
FT                   /note="T -> F (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        30
FT                   /note="F -> L (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   HELIX           5..19
FT                   /evidence="ECO:0007829|PDB:1EMY"
FT   HELIX           22..36
FT                   /evidence="ECO:0007829|PDB:1EMY"
FT   HELIX           38..43
FT                   /evidence="ECO:0007829|PDB:1EMY"
FT   TURN            45..49
FT                   /evidence="ECO:0007829|PDB:1EMY"
FT   HELIX           53..57
FT                   /evidence="ECO:0007829|PDB:1EMY"
FT   HELIX           60..78
FT                   /evidence="ECO:0007829|PDB:1EMY"
FT   TURN            79..81
FT                   /evidence="ECO:0007829|PDB:1EMY"
FT   HELIX           84..96
FT                   /evidence="ECO:0007829|PDB:1EMY"
FT   HELIX           102..119
FT                   /evidence="ECO:0007829|PDB:1EMY"
FT   TURN            121..123
FT                   /evidence="ECO:0007829|PDB:1EMY"
FT   HELIX           126..149
FT                   /evidence="ECO:0007829|PDB:1EMY"
SQ   SEQUENCE   154 AA;  17127 MW;  F1031658D39BEAD5 CRC64;
     MGLSDGEWEL VLKTWGKVEA DIPGHGETVF VRLFTGHPET LEKFDKFKHL KTEGEMKASE
     DLKKQGVTVL TALGGILKKK GHHEAEIQPL AQSHATKHKI PIKYLEFISD AIIHVLQSKH
     PAEFGADAQG AMKKALELFR NDIAAKYKEL GFQG