MYG_MOUSE
ID MYG_MOUSE Reviewed; 154 AA.
AC P04247;
DT 20-MAR-1987, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Myoglobin;
GN Name=Mb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3758071; DOI=10.1111/j.1432-1033.1986.tb09909.x;
RA Blanchetot A., Price M., Jeffreys A.J.;
RT "The mouse myoglobin gene. Characterisation and sequence comparison with
RT other mammalian myoglobin genes.";
RL Eur. J. Biochem. 159:469-474(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 2-154.
RX PubMed=4043406; DOI=10.1016/0014-5793(85)81302-8;
RA Harris D.E., Gurnett A.M., Lehmann H., Joysey K.A.;
RT "The myoglobin of rodents Proechimys guairae (casiragua) and Mus musculus
RT (house mouse).";
RL FEBS Lett. 190:288-292(1985).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-68; THR-75 AND SER-121, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Serves as a reserve supply of oxygen and facilitates the
CC movement of oxygen within muscles.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; BC025172; AAH25172.1; -; mRNA.
DR EMBL; X04405; CAA27994.1; -; Genomic_DNA.
DR EMBL; X04417; CAA27994.1; JOINED; Genomic_DNA.
DR CCDS; CCDS27597.1; -.
DR PIR; A25799; MYMS.
DR RefSeq; NP_001157519.1; NM_001164047.1.
DR RefSeq; NP_001157520.1; NM_001164048.1.
DR RefSeq; NP_038621.2; NM_013593.3.
DR AlphaFoldDB; P04247; -.
DR SMR; P04247; -.
DR BioGRID; 201329; 2.
DR IntAct; P04247; 3.
DR MINT; P04247; -.
DR STRING; 10090.ENSMUSP00000125995; -.
DR iPTMnet; P04247; -.
DR MetOSite; P04247; -.
DR PhosphoSitePlus; P04247; -.
DR SWISS-2DPAGE; P04247; -.
DR CPTAC; non-CPTAC-3847; -.
DR PaxDb; P04247; -.
DR PeptideAtlas; P04247; -.
DR PRIDE; P04247; -.
DR ProteomicsDB; 252629; -.
DR Antibodypedia; 292; 1357 antibodies from 46 providers.
DR DNASU; 17189; -.
DR Ensembl; ENSMUST00000019037; ENSMUSP00000019037; ENSMUSG00000018893.
DR Ensembl; ENSMUST00000166179; ENSMUSP00000128399; ENSMUSG00000018893.
DR Ensembl; ENSMUST00000169226; ENSMUSP00000125995; ENSMUSG00000018893.
DR Ensembl; ENSMUST00000229423; ENSMUSP00000155115; ENSMUSG00000018893.
DR GeneID; 17189; -.
DR KEGG; mmu:17189; -.
DR UCSC; uc007wmx.2; mouse.
DR CTD; 4151; -.
DR MGI; MGI:96922; Mb.
DR VEuPathDB; HostDB:ENSMUSG00000018893; -.
DR eggNOG; KOG3378; Eukaryota.
DR GeneTree; ENSGT00940000160809; -.
DR HOGENOM; CLU_003827_18_0_1; -.
DR InParanoid; P04247; -.
DR OMA; MRLFQDH; -.
DR OrthoDB; 1405713at2759; -.
DR PhylomeDB; P04247; -.
DR TreeFam; TF332967; -.
DR Reactome; R-MMU-8981607; Intracellular oxygen transport.
DR BioGRID-ORCS; 17189; 2 hits in 76 CRISPR screens.
DR ChiTaRS; Mb; mouse.
DR PRO; PR:P04247; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P04247; protein.
DR Bgee; ENSMUSG00000018893; Expressed in digastric muscle group and 137 other tissues.
DR ExpressionAtlas; P04247; baseline and differential.
DR Genevisible; P04247; MM.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; ISO:MGI.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR GO; GO:0050873; P:brown fat cell differentiation; IDA:MGI.
DR GO; GO:0043353; P:enucleate erythrocyte differentiation; IMP:MGI.
DR GO; GO:0007507; P:heart development; IMP:MGI.
DR GO; GO:0015671; P:oxygen transport; ISO:MGI.
DR GO; GO:0009725; P:response to hormone; ISO:MGI.
DR GO; GO:0042542; P:response to hydrogen peroxide; ISO:MGI.
DR GO; GO:0001666; P:response to hypoxia; IMP:MGI.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR002335; Myoglobin.
DR PANTHER; PTHR47132; PTHR47132; 1.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00613; MYOGLOBIN.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Muscle protein;
KW Oxygen transport; Phosphoprotein; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:4043406"
FT CHAIN 2..154
FT /note="Myoglobin"
FT /id="PRO_0000053319"
FT BINDING 65
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT BINDING 94
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT MOD_RES 4
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9QZ76"
FT MOD_RES 68
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 75
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 121
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 116
FT /note="L -> K (in Ref. 3; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 154 AA; 17070 MW; 8EE1EE3FFEE36AF0 CRC64;
MGLSDGEWQL VLNVWGKVEA DLAGHGQEVL IGLFKTHPET LDKFDKFKNL KSEEDMKGSE
DLKKHGCTVL TALGTILKKK GQHAAEIQPL AQSHATKHKI PVKYLEFISE IIIEVLKKRH
SGDFGADAQG AMSKALELFR NDIAAKYKEL GFQG
