ID   MYG_SHEEP               Reviewed;         154 AA.
AC   P02190; A0FH33;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Myoglobin;
GN   Name=MB;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart;
RA   Deng H., Zheng Y.;
RT   "Cloning and characterization of myoglobin cDNA from Ovis aries.";
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 2-154.
RC   TISSUE=Heart muscle;
RX   PubMed=5065743; DOI=10.1111/j.1432-1033.1972.tb01876.x;
RA   Han K., Tetaert D., Moschetto Y., Dautrevaux M., Kopeyan C.;
RT   "The covalent structure of sheep-heart myoglobin.";
RL   Eur. J. Biochem. 27:585-592(1972).
RN   [3]
RP   SEQUENCE REVISION TO 100-102.
RA   Han K.;
RL   Submitted (NOV-1972) to the PIR data bank.
RN   [4]
RP   PROTEIN SEQUENCE OF 141-154.
RX   PubMed=1202228; DOI=10.1007/bf01732218;
RA   Votsch W., Anderer F.A.;
RT   "The amino acid sequence of myoglobin from skeletal muscles of red deer
RT   (Cervus elaphus).";
RL   J. Mol. Evol. 5:315-326(1975).
CC   -!- FUNCTION: Serves as a reserve supply of oxygen and facilitates the
CC       movement of oxygen within muscles.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; DQ995220; ABJ97274.1; -; mRNA.
DR   PIR; A91195; MYSH.
DR   RefSeq; NP_001072126.1; NM_001078658.1.
DR   RefSeq; XP_012015345.1; XM_012159955.2.
DR   AlphaFoldDB; P02190; -.
DR   SMR; P02190; -.
DR   STRING; 9940.ENSOARP00000020014; -.
DR   Ensembl; ENSOART00000020291; ENSOARP00000020014; ENSOARG00000018639.
DR   Ensembl; ENSOART00020032111; ENSOARP00020026520; ENSOARG00020020783.
DR   GeneID; 780509; -.
DR   KEGG; oas:780509; -.
DR   CTD; 4151; -.
DR   eggNOG; KOG3378; Eukaryota.
DR   HOGENOM; CLU_003827_18_0_1; -.
DR   OMA; MRLFQDH; -.
DR   OrthoDB; 1405713at2759; -.
DR   Proteomes; UP000002356; Chromosome 3.
DR   Bgee; ENSOARG00000018639; Expressed in longissimus thoracis muscle and 49 other tissues.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR002335; Myoglobin.
DR   PANTHER; PTHR47132; PTHR47132; 1.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00613; MYOGLOBIN.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Muscle protein;
KW   Oxygen transport; Phosphoprotein; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:5065743"
FT   CHAIN           2..154
FT                   /note="Myoglobin"
FT                   /id="PRO_0000053344"
FT   BINDING         65
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT   BINDING         94
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   MOD_RES         4
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9QZ76"
FT   MOD_RES         68
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P04247"
FT   CONFLICT        21
FT                   /note="D -> G (in Ref. 1; ABJ97274)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        78
FT                   /note="K -> E (in Ref. 1; ABJ97274)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        123
FT                   /note="D -> N (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        146
FT                   /note="Q -> E (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   154 AA;  17055 MW;  E13E47B6C6851761 CRC64;
     MGLSDGEWQL VLNAWGKVEA DVAGHGQEVL IRLFTGHPET LEKFDKFKHL KTEAEMKASE
     DLKKHGNTVL TALGGILKKK GHHEAEVKHL AESHANKHKI PVKYLEFISD AIIHVLHAKH
     PSDFGADAQG AMSKALELFR NDMAAQYKVL GFQG