ID   MYH16_HUMAN             Reviewed;        1097 AA.
AC   Q9H6N6;
DT   27-MAY-2015, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2015, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Putative uncharacterized protein MYH16 {ECO:0000305};
DE   AltName: Full=Myosin heavy chain 16 pseudogene {ECO:0000312|HGNC:HGNC:31038};
DE   AltName: Full=myosin heavy polypeptide 5 {ECO:0000312|HGNC:HGNC:31038};
GN   Name=MYH16 {ECO:0000312|HGNC:HGNC:31038};
GN   Synonyms=MYH5 {ECO:0000312|HGNC:HGNC:31038};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-740.
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   FUNCTION, TISSUE SPECIFICITY, AND CAUTION.
RX   PubMed=15042088; DOI=10.1038/nature02358;
RA   Stedman H.H., Kozyak B.W., Nelson A., Thesier D.M., Su L.T., Low D.W.,
RA   Bridges C.R., Shrager J.B., Minugh-Purvis N., Mitchell M.A.;
RT   "Myosin gene mutation correlates with anatomical changes in the human
RT   lineage.";
RL   Nature 428:415-418(2004).
RN   [4]
RP   CAUTION.
RX   PubMed=16376411; DOI=10.1016/j.jhevol.2005.10.003;
RA   McCollum M.A., Sherwood C.C., Vinyard C.J., Lovejoy C.O., Schachat F.;
RT   "Of muscle-bound crania and human brain evolution: the story behind the
RT   MYH16 headlines.";
RL   J. Hum. Evol. 50:232-236(2006).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY, AND CAUTION.
RX   PubMed=24240322; DOI=10.1038/nmeth.2732;
RA   Branca R.M., Orre L.M., Johansson H.J., Granholm V., Huss M.,
RA   Perez-Bercoff A., Forshed J., Kaell L., Lehtioe J.;
RT   "HiRIEF LC-MS enables deep proteome coverage and unbiased proteogenomics.";
RL   Nat. Methods 11:59-62(2014).
CC   -!- FUNCTION: Has most probably lost the function in masticatory muscles
CC       contraction suspected for its homologs in dog (AC F1PT61) and apes.
CC       {ECO:0000303|PubMed:15042088}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in muscles of the head
CC       including temporalis and tensor veli palatini.
CC       {ECO:0000269|PubMed:15042088}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000305}.
CC   -!- CAUTION: An inactivating mutation in MYH16 probably appeared 2.4
CC       million years ago in a hominid ancestor (PubMed:15042088). The
CC       inactivation and its correlation with evolution of the skull and
CC       cranial capacity in hominids is not clear (PubMed:15042088,
CC       PubMed:16376411). However, the gene is transcribed and the N-terminally
CC       truncated protein shown here was detected in a human cell line
CC       (PubMed:24240322). Its biological significance remains unclear since it
CC       lacks most of the domains important for the function of myosins
CC       (PubMed:15042088). {ECO:0000269|PubMed:15042088,
CC       ECO:0000269|PubMed:16376411, ECO:0000269|PubMed:24240322}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB15219.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR   EMBL; AC004834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AK025690; BAB15219.1; ALT_SEQ; mRNA.
DR   AlphaFoldDB; Q9H6N6; -.
DR   SMR; Q9H6N6; -.
DR   IntAct; Q9H6N6; 1.
DR   iPTMnet; Q9H6N6; -.
DR   PhosphoSitePlus; Q9H6N6; -.
DR   BioMuta; HGNC:31038; -.
DR   jPOST; Q9H6N6; -.
DR   MassIVE; Q9H6N6; -.
DR   PeptideAtlas; Q9H6N6; -.
DR   PRIDE; Q9H6N6; -.
DR   GeneCards; MYH16; -.
DR   HGNC; HGNC:31038; MYH16.
DR   neXtProt; NX_Q9H6N6; -.
DR   PathwayCommons; Q9H6N6; -.
DR   SignaLink; Q9H6N6; -.
DR   Pharos; Q9H6N6; Tdark.
DR   PRO; PR:Q9H6N6; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q9H6N6; protein.
DR   GO; GO:0005814; C:centriole; IBA:GO_Central.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR   Gene3D; 1.20.5.370; -; 4.
DR   InterPro; IPR002928; Myosin_tail.
DR   InterPro; IPR014751; XRCC4-like_C.
DR   Pfam; PF01576; Myosin_tail_1; 2.
PE   1: Evidence at protein level;
KW   Coiled coil; Reference proteome.
FT   CHAIN           1..1097
FT                   /note="Putative uncharacterized protein MYH16"
FT                   /id="PRO_0000433095"
FT   COILED          31..1087
FT                   /evidence="ECO:0000255"
FT   CONFLICT        11
FT                   /note="H -> R (in Ref. 2; BAB15219)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1097 AA;  128290 MW;  DC459CD5FA5D0BC4 CRC64;
     MGLKVIQQNV HKFLQLRFWG WWKLYNKVKP LLNVARQEEE MKAKEEELRK AMAQTQELVN
     KVKELEEKTA TLSQEKNDLT IQLQAEQENL MDAEERLTWM MKTKMDLESQ ISDMRERLEE
     EEGMAASLSA AKRKLEGELS DLKRDLEGLE TTLAKTEKEK QALDHKVRTL TGDLSLREDS
     ITKLQKEKRA LEELHQKTLD DLQAEEDKVN HLTKNNSKLS TQIHELEDNW EQEKKIRAEV
     EKARRKAESD LKMTIDNLNE MERSKLDLEE VVKKRDLEIN SVNSKYEDEQ SLNSTLQRKL
     KEHQDRIEEL EEELEAERAM RAKIEQNRKR EAELLKLRRE LEEAALQSEA TASTLRKKHV
     DSMAELTEHV ESLQRVKSKL EKDKQVMKAE IDDLNASMET IQKSKMNAEA HVRKLEDSLS
     EANAKVAELE RNQAEINAIR TRLQAENSEL SREYEESQSR LNQILRIKTS LTSQVDDYKR
     QLDEESKSRS TAVVSLANTK HDLDLVKEQL EEEQGGKSEL QRLVSKLNTE VTTWRTKYET
     DAIQRTEELE ETKRKLAARL QEAEEAAETA QARAASLEKN KQRLQAEVED LTIDLEKANA
     AAAALDKKQR LFDKMLAEWQ QKCEELQVEV DSSQKECRMY MTESFKIKTA YEESLEHLES
     VKKENKTLQE EIKDLIDQLG EGGRSVHELQ KLKKKLEMEK EELQVALEEA ESSLEVEESK
     VIRIQLELAQ VKADIDRRIH EKEEEFEATR KNHQRAIESL QASLEAEAKG RAEALRLKKK
     METDLNEMEI QLDHANKNNS ELVKTLKRLQ QQIKDLQVQM DEDARQHEEL RKQYNLQERR
     LSLLQTELEE VRSALEGSER SRKLLEQEVV EITEWHNEIN IQNQSLLVVK RKLESDVQRI
     SNEHEELISE FRLTEERAKK AMMDAARMAE ELRQEQDHCM HLEKIKKNYE VTIKDLQAKM
     EEAEQLALKG GKRTIMKLEA RIKELETELD GEQKQHVETV KTLCKNERRL KELVFQTEED
     HKTNQRMQAL VEKLQNKLKV YKRQIEEAED QANQTLARYR KTVHELDDAE DRAGMAETAL
     NKLRTRHRVA GKGITSV