ID   MYH6_RABIT              Reviewed;         465 AA.
AC   P04460; Q28712;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Myosin-6;
DE   AltName: Full=Alpha isomyosin;
DE   AltName: Full=Myosin heavy chain 6;
DE   AltName: Full=Myosin heavy chain, cardiac muscle alpha isoform;
DE            Short=MyHC-alpha;
DE   Flags: Fragment;
GN   Name=MYH6;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=6321481; DOI=10.1016/s0021-9258(17)43213-3;
RA   Kavinsky C.J., Umeda P.K., Levin J.E., Sinha A.M., Nigro J.M., Jakovcic S.,
RA   Rabinowitz M.;
RT   "Analysis of cloned mRNA sequences encoding subfragment 2 and part of
RT   subfragment 1 of alpha- and beta-myosin heavy chains of rabbit heart.";
RL   J. Biol. Chem. 259:2775-2781(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 91-177.
RX   PubMed=6328491; DOI=10.1073/pnas.81.10.3044;
RA   Friedman D.J., Umeda P.K., Sinha A.M., Hsu H.J., Jokovcic S.,
RA   Rabinowitz M.;
RT   "Characterization of genomic clones specifying rabbit alpha- and beta-
RT   ventricular myosin heavy chains.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:3044-3048(1984).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 233-353.
RX   PubMed=6193509; DOI=10.1073/pnas.79.19.5847;
RA   Sinha A.M., Umeda P.K., Kavinsky C.J., Rajamanickam C., Hsu H.J.,
RA   Jakovcic S., Rabinowitz M.;
RT   "Molecular cloning of mRNA sequences for cardiac alpha- and beta-form
RT   myosin heavy chains: expression in ventricles of normal, hypothyroid, and
RT   thyrotoxic rabbits.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:5847-5851(1982).
CC   -!- FUNCTION: Muscle contraction.
CC   -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC       chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC       regulatory light chain subunits (MLC-2).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the
CC       myofibrils.
CC   -!- DOMAIN: The rodlike tail sequence is highly repetitive, showing cycles
CC       of a 28-residue repeat pattern composed of 4 heptapeptides,
CC       characteristic for alpha-helical coiled coils.
CC   -!- DOMAIN: Limited proteolysis of myosin heavy chain produces 1 light
CC       meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further
CC       cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment
CC       (S2). {ECO:0000305}.
CC   -!- CAUTION: Represents a conventional myosin. This protein should not be
CC       confused with the unconventional myosin-6 (MYO6). {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; K02443; AAA31412.1; -; mRNA.
DR   EMBL; K01697; AAA31416.1; -; mRNA.
DR   EMBL; J00671; AAA31410.1; -; mRNA.
DR   PIR; A02986; A02986.
DR   AlphaFoldDB; P04460; -.
DR   SMR; P04460; -.
DR   InParanoid; P04460; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002928; Myosin_tail.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; ATP-binding; Coiled coil; Cytoplasm; Motor protein;
KW   Muscle protein; Myosin; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Thick filament.
FT   CHAIN           <1..>465
FT                   /note="Myosin-6"
FT                   /id="PRO_0000123405"
FT   DOMAIN          <1..35
FT                   /note="Myosin motor"
FT   COILED          36..>465
FT                   /evidence="ECO:0000255"
FT   MOD_RES         285
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02563"
FT   MOD_RES         334
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02563"
FT   MOD_RES         456
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:P02563"
FT   CONFLICT        271
FT                   /note="Q -> L (in Ref. 3; AAA31410)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT   NON_TER         465
SQ   SEQUENCE   465 AA;  54376 MW;  BAC86AFF8CE8E29C CRC64;
     ILERGDALLV VQWNIRAFTG VKKWPWMELY FEIEPLLKSA EAEKEMAAMK EEFGRIKESL
     EKSEARRKEL EEKMVSLLQE KNDLQLQVQA EQDNLNDAEE RCDQLIKNKI QLEAKVKEMN
     ERLEDEEEMN AELTAKKRKL EDECSELKKD IDDLELTLAK VEKEKHATEN KVKNLTEEMA
     GLDEIIAKLT KEKKALQEAH QQALDDLQAE EDKVNTLTKA KLKLEQQVDD LEGSLEQEKK
     VRMDLERAKR KLEGDLKLTQ ESIMDLENDK QQLEERLKKK EFDISQLNSK IEDEQALVLQ
     LQKKLKENQA RIEELEEELE AERTARAKVE KLRSDLSREL EEISERLEEA GGATSVQIEM
     NKKREAEFQK MRRDLEEATL QHEATASALR RKHADSVAEL GEQIDNLQRV KQKLEKEKSE
     FKLELDDVTS NMEQIIKAKA NLEKVSRTLE DQANEYRRKL EEAQR