MYH7B_HUMAN
ID MYH7B_HUMAN Reviewed; 1983 AA.
AC A7E2Y1; Q5JVW7; Q6NT44; Q6NT57; Q6WG75; Q96I57; Q9NWE2; Q9P216;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 4.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Myosin-7B;
DE AltName: Full=Antigen MLAA-21;
DE AltName: Full=Myosin cardiac muscle beta chain;
DE AltName: Full=Myosin heavy chain 7B, cardiac muscle beta isoform;
DE AltName: Full=Slow A MYH14;
GN Name=MYH7B; Synonyms=KIAA1512;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND SUBCELLULAR LOCATION.
RX PubMed=15755502; DOI=10.1016/j.leukres.2004.09.013;
RA Chen G., Zhang W.G., Cao X.M., Li F.Y., Liu X.P., Yao L.B.;
RT "Serological identification of immunogenic antigens in acute monocytic
RT leukemia.";
RL Leuk. Res. 29:503-509(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), DEVELOPMENTAL STAGE,
RP AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION.
RX PubMed=11919279; DOI=10.1093/oxfordjournals.molbev.a004093;
RA Desjardins P.R., Burkman J.M., Shrager J.B., Allmond L.A., Stedman H.H.;
RT "Evolutionary implications of three novel members of the human sarcomeric
RT myosin heavy chain gene family.";
RL Mol. Biol. Evol. 19:375-393(2002).
CC -!- FUNCTION: Involved in muscle contraction.
CC {ECO:0000269|PubMed:11919279}.
CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC regulatory light chain subunits (MLC-2). {ECO:0000250}.
CC -!- INTERACTION:
CC A7E2Y1; Q8NB12: SMYD1; NbExp=2; IntAct=EBI-2880253, EBI-8463848;
CC A7E2Y1-2; Q16134: ETFDH; NbExp=3; IntAct=EBI-12813813, EBI-2870454;
CC A7E2Y1-2; P78337: PITX1; NbExp=3; IntAct=EBI-12813813, EBI-748265;
CC A7E2Y1-2; Q2TAL8: QRICH1; NbExp=3; IntAct=EBI-12813813, EBI-2798044;
CC A7E2Y1-2; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-12813813, EBI-740343;
CC A7E2Y1-2; Q8NB12: SMYD1; NbExp=3; IntAct=EBI-12813813, EBI-8463848;
CC A7E2Y1-2; Q08117-2: TLE5; NbExp=3; IntAct=EBI-12813813, EBI-11741437;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:15755502};
CC Peripheral membrane protein {ECO:0000269|PubMed:15755502}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A7E2Y1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A7E2Y1-2; Sequence=VSP_059497, VSP_059498;
CC Name=3;
CC IsoId=A7E2Y1-3; Sequence=VSP_035359, VSP_035361;
CC -!- TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, testis, and
CC all specific brain regions examined. Slightly lower expression was
CC detected in ovary and kidney, and intermediate expression was detected
CC in lung, pancreas, spleen and liver. {ECO:0000269|PubMed:10819331}.
CC -!- DEVELOPMENTAL STAGE: Found in fetal liver and brain.
CC {ECO:0000269|PubMed:10819331}.
CC -!- MISCELLANEOUS: Expression does not vary in normal patients compared to
CC patients with acute monocytic leukemia.
CC -!- MISCELLANEOUS: The cardiac alpha isoform is a 'fast' ATPase myosin,
CC while the beta isoform is a 'slow' ATPase.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000305}.
CC -!- CAUTION: This protein sequence has been named 'Slow A' MYH14, but it
CC also appears also as 'Slow B' MYH15 within the reference.
CC {ECO:0000305|PubMed:11919279}.
CC -!- CAUTION: Represents a conventional myosin. This protein should not be
CC confused with the unconventional myosin-7 (MYO7). {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA96036.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY288964; AAQ93060.1; -; mRNA.
DR EMBL; AB040945; BAA96036.2; ALT_INIT; mRNA.
DR EMBL; AK000947; BAA91440.1; -; mRNA.
DR EMBL; AL133324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL132825; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF456882; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471077; EAW76237.1; -; Genomic_DNA.
DR EMBL; BC007808; AAH07808.1; -; mRNA.
DR EMBL; BC069327; AAH69327.2; -; mRNA.
DR EMBL; BC069406; AAH69406.2; -; mRNA.
DR EMBL; BC151242; AAI51243.1; -; mRNA.
DR RefSeq; NP_065935.3; NM_020884.4. [A7E2Y1-1]
DR AlphaFoldDB; A7E2Y1; -.
DR SMR; A7E2Y1; -.
DR BioGRID; 121681; 60.
DR IntAct; A7E2Y1; 24.
DR MINT; A7E2Y1; -.
DR STRING; 9606.ENSP00000262873; -.
DR ChEMBL; CHEMBL3831286; -.
DR iPTMnet; A7E2Y1; -.
DR PhosphoSitePlus; A7E2Y1; -.
DR SwissPalm; A7E2Y1; -.
DR BioMuta; MYH7B; -.
DR EPD; A7E2Y1; -.
DR jPOST; A7E2Y1; -.
DR MassIVE; A7E2Y1; -.
DR MaxQB; A7E2Y1; -.
DR PaxDb; A7E2Y1; -.
DR PeptideAtlas; A7E2Y1; -.
DR PRIDE; A7E2Y1; -.
DR ProteomicsDB; 1802; -. [A7E2Y1-1]
DR ProteomicsDB; 1804; -. [A7E2Y1-3]
DR Antibodypedia; 54800; 47 antibodies from 8 providers.
DR DNASU; 57644; -.
DR Ensembl; ENST00000618182.6; ENSP00000483640.3; ENSG00000078814.18.
DR GeneID; 57644; -.
DR KEGG; hsa:57644; -.
DR UCSC; uc061wko.1; human. [A7E2Y1-1]
DR CTD; 57644; -.
DR DisGeNET; 57644; -.
DR GeneCards; MYH7B; -.
DR HGNC; HGNC:15906; MYH7B.
DR HPA; ENSG00000078814; Group enriched (heart muscle, skeletal muscle).
DR MalaCards; MYH7B; -.
DR MIM; 609928; gene.
DR neXtProt; NX_A7E2Y1; -.
DR Orphanet; 54260; Left ventricular noncompaction.
DR PharmGKB; PA31375; -.
DR VEuPathDB; HostDB:ENSG00000078814; -.
DR eggNOG; KOG0161; Eukaryota.
DR InParanoid; A7E2Y1; -.
DR OrthoDB; 47111at2759; -.
DR PhylomeDB; A7E2Y1; -.
DR TreeFam; TF314375; -.
DR PathwayCommons; A7E2Y1; -.
DR SignaLink; A7E2Y1; -.
DR BioGRID-ORCS; 57644; 32 hits in 1071 CRISPR screens.
DR ChiTaRS; MYH7B; human.
DR GeneWiki; MYH7B; -.
DR GenomeRNAi; 57644; -.
DR Pharos; A7E2Y1; Tbio.
DR PRO; PR:A7E2Y1; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; A7E2Y1; protein.
DR Bgee; ENSG00000078814; Expressed in apex of heart and 126 other tissues.
DR ExpressionAtlas; A7E2Y1; baseline and differential.
DR Genevisible; A7E2Y1; HS.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032982; C:myosin filament; IBA:GO_Central.
DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 2.30.30.360; -; 1.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Alternative splicing; ATP-binding; Coiled coil; Membrane;
KW Motor protein; Muscle protein; Myosin; Nucleotide-binding;
KW Reference proteome; Thick filament.
FT CHAIN 1..1983
FT /note="Myosin-7B"
FT /id="PRO_0000349312"
FT DOMAIN 72..122
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01190"
FT DOMAIN 126..827
FT /note="Myosin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT DOMAIN 830..859
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 704..726
FT /note="Actin-binding"
FT /evidence="ECO:0000250"
FT REGION 806..820
FT /note="Actin-binding"
FT /evidence="ECO:0000250"
FT REGION 1946..1983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 888..1977
FT /evidence="ECO:0000255"
FT BINDING 219..226
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..1809
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15755502"
FT /id="VSP_035359"
FT VAR_SEQ 1..42
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_059497"
FT VAR_SEQ 219..1983
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_059498"
FT VAR_SEQ 1810..1811
FT /note="DA -> MP (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15755502"
FT /id="VSP_035361"
FT VARIANT 70
FT /note="P -> T (in dbSNP:rs17092199)"
FT /id="VAR_046359"
FT VARIANT 501
FT /note="F -> Y (in dbSNP:rs754511)"
FT /id="VAR_046360"
FT VARIANT 780
FT /note="P -> S (in dbSNP:rs3746442)"
FT /id="VAR_046361"
FT VARIANT 1007
FT /note="E -> K (in dbSNP:rs2425015)"
FT /id="VAR_054814"
FT VARIANT 1552
FT /note="K -> N (in dbSNP:rs3746435)"
FT /id="VAR_046362"
FT VARIANT 1581
FT /note="A -> V (in dbSNP:rs6060147)"
FT /id="VAR_046363"
FT VARIANT 1698
FT /note="Q -> R (in dbSNP:rs6060148)"
FT /id="VAR_046364"
FT VARIANT 1917
FT /note="V -> E (in dbSNP:rs7273482)"
FT /id="VAR_046365"
FT CONFLICT 979
FT /note="E -> G (in Ref. 6; AAH07808)"
FT /evidence="ECO:0000305"
FT CONFLICT 1900
FT /note="A -> V (in Ref. 1; AAQ93060)"
FT /evidence="ECO:0000305"
FT CONFLICT 1903
FT /note="A -> T (in Ref. 1; AAQ93060)"
FT /evidence="ECO:0000305"
FT CONFLICT 1939
FT /note="N -> S (in Ref. 1; AAQ93060)"
FT /evidence="ECO:0000305"
FT CONFLICT 1973
FT /note="T -> S (in Ref. 1; AAQ93060)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1983 AA; 225845 MW; 407E723E41DEB9A8 CRC64;
MSGNKRGSRA SCPHRGAECL LPWAALNLQG FQLLLLHPSA TAMMDVSELG ESARYLRQGY
QEMTKVHTIP WDGKKRVWVP DEQDAYVEAE VKSEATGGRV TVETKDQKVL MVREAELQPM
NPPRFDLLED MAMMTHLNEA SVLHNLRQRY ARWMIYTYSG LFCVTINPYK WLPVYTASVV
AAYKGKRRSD SPPHIYAVAD NAYNDMLRNR DNQSMLITGE SGAGKTVNTK RVIQYFAIVA
ALGDGPGKKA QFLATKTGGT LEDQIIEANP AMEAFGNAKT LRNDNSSRFG KFIRIHFGPS
GKLASADIDS YLLEKSRVIF QLPGERSYHV YYQILSGRKP ELQDMLLLSM NPYDYHFCSQ
GVITVDNMND GEELIATDHA MDILGFSVDE KCACYKIVGA LLHFGNMKFK QKQREEQAEA
DGTESADKAA YLMGVSSGDL LKGLLHPRVR VGNEYVTKGQ SVEQVVFAVG ALAKATYDRL
FRWLVSRINQ TLDTKLPRQF FIGVLDIAGF EIFEFNSFEQ LCINFTNEKL QQFFNQHMFV
LEQEEYKREG IDWVFIDFGL DLQPCIDLIE KPLGILSILE EECMFPKASD ASFRAKLYDN
HAGKSPNFQQ PRPDKKRKYQ AHFEVVHYAG VVPYSIVGWL EKNKDPLNET VVPIFQKSQN
RLLATLYENY AGSCSTEPPK SGVKEKRKKA ASFQTVSQLH KENLNKLMTN LRATQPHFVR
CIVPNENKTP GVMDAFLVLH QLRCNGVLEG IRICRQGFPN RLLYTDFRQR YRILNPSAIP
DDTFMDSRKA TEKLLGSLDL DHTQYQFGHT KVFFKAGLLG VLEELRDQRL AKVLTLLQAR
SRGRLMRLEY QRLLGGRDAL FTIQWNIRAF NAVKNWSWMK LFFKMKPLLR SAQAEEELAA
LRAELRGLRG ALAAAEAKRQ ELEETHVSIT QEKNDLALQL QAEQDNLADA EERCHLLIKS
KVQLEGKVKE LSERLEDEEE VNADLAARRR KLEDECTELK KDIDDLELTL AKAEKEKQAT
ENKVKNLTEE MAALDESVAR LTKEKKALQE AHQQALGDLQ AEEDRVSALT KAKLRLEQQV
EDLECSLEQE KKLRMDTERA KRKLEGDLKL TQESVADAAQ DKQQLEEKLK KKDSELSQLS
LRVEDEQLLG AQMQKKIKEL QARAEELEEE LEAERAARAR VEKQRAEAAR ELEELSERLE
EAGGASAGQR EGCRKREAEL GRLRRELEEA ALRHEATVAA LRRKQAEGAA ELGEQVDSLQ
RVRQKLEKEK SELRMEVDDL AANVETLTRA KASAEKLCRT YEDQLSEAKI KVEELQRQLA
DASTQRGRLQ TESGELSRLL EEKECLISQL SRGKALAAQS LEELRRQLEE ESKAKSALAH
AVQALRHDCD LLREQHEEEA EAQAELQRLL SKANAEVAQW RSKYEADAIQ RTEELEEAKK
KLALRLQEAE EGVEAANAKC SSLEKAKLRL QTESEDVTLE LERATSAAAA LDKKQRHLER
ALEERRRQEE EMQRELEAAQ RESRGLGTEL FRLRHGHEEA LEALETLKRE NKNLQEEISD
LTDQVSLSGK SIQELEKTKK ALEGEKSEIQ AALEEAEGAL ELEETKTLRI QLELSQVKAE
VDRKLAEKDE ECANLRRNHQ RAVESLQASL DAETRARNEA LRLKKKMEGD LNDLELQLGH
ATRQATEAQA ATRLMQAQLK EEQAGRDEEQ RLAAELHEQA QALERRASLL AAELEELRAA
LEQGERSRRL AEQELLEATE RLNLLHSQNT GLLNQKKKLE ADLAQLSGEV EEAAQERREA
EEKAKKAITD AAMMAEELKK EQDTSAHLER MKKTLEQTVR ELQARLEEAE QAALRGGKKQ
VQKLEAKVRE LEAELDAEQK KHAEALKGVR KHERRVKELA YQAEEDRKNL ARMQDLVDKL
QSKVKSYKRQ FEEAEQQANT NLAKYRKAQH ELDDAEERAD MAETQANKLR ARTRDALGPK
HKE
