ID   MYH7_PAPHA              Reviewed;         244 AA.
AC   P11778;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Myosin-7;
DE   AltName: Full=Myosin heavy chain 7;
DE   AltName: Full=Myosin heavy chain slow isoform;
DE            Short=MyHC-slow;
DE   AltName: Full=Myosin heavy chain, cardiac muscle beta isoform;
DE            Short=MyHC-beta;
DE   Flags: Fragment;
GN   Name=MYH7;
OS   Papio hamadryas (Hamadryas baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=3396877; DOI=10.1016/0378-1119(88)90478-7;
RA   Hixson J.E., Britten M.L.;
RT   "The baboon beta-myosin heavy-chain gene: construction and characterization
RT   of cDNA clones and gene expression in cardiac tissues.";
RL   Gene 64:33-42(1988).
CC   -!- FUNCTION: Myosins are actin-based motor molecules with ATPase activity
CC       essential for muscle contraction. Forms regular bipolar thick filaments
CC       that, together with actin thin filaments, constitute the fundamental
CC       contractile unit of skeletal and cardiac muscle.
CC       {ECO:0000250|UniProtKB:P12883}.
CC   -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC       chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC       regulatory light chain subunits (MLC-2). Interacts with ECPAS.
CC       Interacts (via C-terminus) with LRRC39. {ECO:0000250|UniProtKB:P12883}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC       {ECO:0000250|UniProtKB:P02564}. Cytoplasm, myofibril, sarcomere
CC       {ECO:0000250|UniProtKB:P02564}. Note=Thick filaments of the myofibrils.
CC       {ECO:0000250|UniProtKB:P02564}.
CC   -!- DOMAIN: Limited proteolysis of myosin heavy chain produces 1 light
CC       meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further
CC       cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment
CC       (S2). {ECO:0000305}.
CC   -!- DOMAIN: The rodlike tail sequence is highly repetitive, showing cycles
CC       of a 28-residue repeat pattern composed of 4 heptapeptides,
CC       characteristic for alpha-helical coiled coils. Four skip residues
CC       (Skip1-4) introduce discontinuities in the coiled-coil heptad repeats.
CC       The first three skip residues are structurally comparable and induce a
CC       unique local relaxation of the coiled-coil superhelical pitch and the
CC       fourth skip residue lies within a highly flexible molecular hinge that
CC       is necessary for myosin incorporation in the bare zone of sarcomeres.
CC       {ECO:0000250|UniProtKB:P12883}.
CC   -!- MISCELLANEOUS: The cardiac alpha isoform is a 'fast' ATPase myosin,
CC       while the beta isoform is a 'slow' ATPase.
CC   -!- CAUTION: Represents a conventional myosin. This protein should not be
CC       confused with the unconventional myosin-7 (MYO7). {ECO:0000305}.
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DR   EMBL; M19932; AAA35384.1; -; mRNA.
DR   PIR; I36913; I36913.
DR   AlphaFoldDB; P11778; -.
DR   SMR; P11778; -.
DR   GO; GO:0030016; C:myofibril; ISS:UniProtKB.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032982; C:myosin filament; ISS:UniProtKB.
DR   GO; GO:0030017; C:sarcomere; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.370; -; 2.
DR   InterPro; IPR002928; Myosin_tail.
DR   InterPro; IPR014751; XRCC4-like_C.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; ATP-binding; Coiled coil; Cytoplasm; Motor protein;
KW   Muscle protein; Myosin; Nucleotide-binding; Thick filament.
FT   CHAIN           <1..244
FT                   /note="Myosin-7"
FT                   /id="PRO_0000123409"
FT   REGION          <1..244
FT                   /note="Rodlike tail (S2 and LMM domains)"
FT   REGION          216..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          <1..244
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
SQ   SEQUENCE   244 AA;  28434 MW;  31F3ECC3FC53BB85 CRC64;
     VEQTERSRKL AEQELIETSE RVQLLHSQNT SLINQKKKMD ADLSQLQTEV EEAVQECRNA
     EEKAKKAITD AAMMAEELKK EQDTSAHLER MKKNMEQTIK DLQHRLDEAE QIALKGGKKQ
     LQKLEARVRE LENELEAEQK RNAESVKGMR KSERRIKELT YQTEEDRKNL LRLQDLVDKL
     QLKVKAYKRQ AEEAEEQANT NLSKFRKVQH ELDEAEERAD IAESQVNKLR AKSRDIGTKG
     LNEE