MYHV1_BOMMX
ID MYHV1_BOMMX Reviewed; 142 AA.
AC Q58T91;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 34.
DE RecName: Full=Maximins y/Hv type 1;
DE Contains:
DE RecName: Full=Maximin-y;
DE Contains:
DE RecName: Full=Maximin-Hv;
DE Flags: Precursor;
OS Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Bombinatoridae; Bombina.
OX NCBI_TaxID=161274;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Skin;
RX PubMed=15770703; DOI=10.1002/eji.200425615;
RA Lee W.-H., Li Y., Lai R., Li S., Zhang Y., Wang W.;
RT "Variety of antimicrobial peptides in the Bombina maxima toad and evidence
RT of their rapid diversification.";
RL Eur. J. Immunol. 35:1220-1229(2005).
CC -!- FUNCTION: Maximin-y shows antimicrobial activity against bacteria and
CC against the fungus C.albicans. It has little hemolytic activity (By
CC similarity). {ECO:0000250}.
CC -!- FUNCTION: Maximin-Hv shows antimicrobial activity against bacteria and
CC against the fungus C.albicans. Shows strong hemolytic activity (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC -!- SIMILARITY: Belongs to the bombinin family. {ECO:0000305}.
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DR EMBL; AY847753; AAX50247.1; -; Genomic_DNA.
DR AlphaFoldDB; Q58T91; -.
DR SMR; Q58T91; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR InterPro; IPR007962; Bombinin.
DR Pfam; PF05298; Bombinin; 1.
PE 2: Evidence at transcript level;
KW Amidation; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Cleavage on pair of basic residues; Cytolysis; Fungicide; Hemolysis;
KW Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..43
FT /evidence="ECO:0000250"
FT /id="PRO_0000003244"
FT PEPTIDE 44..68
FT /note="Maximin-y"
FT /id="PRO_0000003245"
FT PROPEP 72..121
FT /evidence="ECO:0000305"
FT /id="PRO_0000003246"
FT PEPTIDE 122..141
FT /note="Maximin-Hv"
FT /id="PRO_0000003247"
FT MOD_RES 68
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000305"
FT MOD_RES 141
FT /note="Isoleucine amide"
FT /evidence="ECO:0000305"
SQ SEQUENCE 142 AA; 15632 MW; 811889DA4B891C6C CRC64;
MNFKYIVAVS FLIASGYARS EENDVQSLSQ REVLEEESLR EIRGIGGALL SAGKSALKGL
AKGFAEHFGK RTAEDHEVMK RLEAVMRDLD SLDHPEEASE RETRGFNQEE IANLFTKKEK
RILGPVLSLV GSALGGLIKK IG