MYL10_HUMAN
ID MYL10_HUMAN Reviewed; 226 AA.
AC Q9BUA6;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Myosin regulatory light chain 10;
DE AltName: Full=Myosin light chain 2, lymphocyte-specific;
DE AltName: Full=Precursor lymphocyte-specific regulatory light chain;
GN Name=MYL10; Synonyms=MYLC2PL, PLRLC;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
CC -!- INTERACTION:
CC Q9BUA6; P36508: ZNF76; NbExp=3; IntAct=EBI-17561739, EBI-7254550;
CC -!- MISCELLANEOUS: This chain binds calcium. {ECO:0000250}.
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DR EMBL; CH471197; EAW50226.1; -; Genomic_DNA.
DR EMBL; BC002778; AAH02778.2; -; mRNA.
DR CCDS; CCDS34713.1; -.
DR RefSeq; NP_612412.2; NM_138403.4.
DR AlphaFoldDB; Q9BUA6; -.
DR SMR; Q9BUA6; -.
DR BioGRID; 125022; 33.
DR IntAct; Q9BUA6; 3.
DR STRING; 9606.ENSP00000223167; -.
DR iPTMnet; Q9BUA6; -.
DR PhosphoSitePlus; Q9BUA6; -.
DR BioMuta; MYL10; -.
DR DMDM; 74761268; -.
DR MassIVE; Q9BUA6; -.
DR PaxDb; Q9BUA6; -.
DR PeptideAtlas; Q9BUA6; -.
DR PRIDE; Q9BUA6; -.
DR ProteomicsDB; 79068; -.
DR Antibodypedia; 16757; 34 antibodies from 12 providers.
DR DNASU; 93408; -.
DR Ensembl; ENST00000223167.5; ENSP00000223167.4; ENSG00000106436.7.
DR GeneID; 93408; -.
DR KEGG; hsa:93408; -.
DR MANE-Select; ENST00000223167.5; ENSP00000223167.4; NM_138403.5; NP_612412.2.
DR UCSC; uc003uyr.3; human.
DR CTD; 93408; -.
DR GeneCards; MYL10; -.
DR HGNC; HGNC:29825; MYL10.
DR HPA; ENSG00000106436; Not detected.
DR neXtProt; NX_Q9BUA6; -.
DR OpenTargets; ENSG00000106436; -.
DR PharmGKB; PA164723254; -.
DR VEuPathDB; HostDB:ENSG00000106436; -.
DR eggNOG; KOG0031; Eukaryota.
DR GeneTree; ENSGT00940000161811; -.
DR HOGENOM; CLU_061288_9_0_1; -.
DR InParanoid; Q9BUA6; -.
DR OMA; FPPDMCG; -.
DR OrthoDB; 1435392at2759; -.
DR PhylomeDB; Q9BUA6; -.
DR TreeFam; TF314218; -.
DR PathwayCommons; Q9BUA6; -.
DR Reactome; R-HSA-445355; Smooth Muscle Contraction.
DR SignaLink; Q9BUA6; -.
DR BioGRID-ORCS; 93408; 8 hits in 1070 CRISPR screens.
DR GenomeRNAi; 93408; -.
DR Pharos; Q9BUA6; Tdark.
DR PRO; PR:Q9BUA6; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9BUA6; protein.
DR Bgee; ENSG00000106436; Expressed in olfactory bulb and 153 other tissues.
DR ExpressionAtlas; Q9BUA6; baseline and differential.
DR Genevisible; Q9BUA6; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005739; C:mitochondrion; IDA:LIFEdb.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 1: Evidence at protein level;
KW Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..226
FT /note="Myosin regulatory light chain 10"
FT /id="PRO_0000322130"
FT DOMAIN 84..119
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 154..189
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 190..225
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 97
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 99
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 101
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 108
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT VARIANT 46
FT /note="M -> T (in dbSNP:rs12216595)"
FT /id="VAR_039401"
SQ SEQUENCE 226 AA; 25308 MW; BC9E7976D178D0B9 CRC64;
MLLRLVSNSW PQVILPPRPP KVLGLQAPRR ARKRAEGTAS SNVFSMFDQS QIQEFKESLA
LSPRLERNGM ISAHCNLCLT GSSNSPASAS QAFTIMDQNR DGFIDKEDLR DTFAALGRIN
VKNEELEAMV KEAPGPINFT VFLTMFGEKL KGTDPEETIL HAFKVFDTEG KGFVKADVIK
EKLMTQADRF SEEEVKQMFA AFPPDVCGNL DYRNLCYVIT HGEEKD
