ID   MYL4_RAT                Reviewed;         193 AA.
AC   P17209;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Myosin light chain 4;
DE   AltName: Full=Myosin light chain 1, atrial isoform;
GN   Name=Myl4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Heart;
RX   PubMed=2326197;
RA   Rovner A.S., McNally E.M., Leinwand L.A.;
RT   "Complete cDNA sequence of rat atrial myosin light chain 1: patterns of
RT   expression during development and with hypertension.";
RL   Nucleic Acids Res. 18:1581-1586(1990).
CC   -!- FUNCTION: Regulatory light chain of myosin. Does not bind calcium.
CC       {ECO:0000305}.
CC   -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
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DR   EMBL; X51531; CAA35911.1; -; mRNA.
DR   PIR; S09236; MORT4E.
DR   AlphaFoldDB; P17209; -.
DR   SMR; P17209; -.
DR   IntAct; P17209; 1.
DR   STRING; 10116.ENSRNOP00000064224; -.
DR   iPTMnet; P17209; -.
DR   PhosphoSitePlus; P17209; -.
DR   PaxDb; P17209; -.
DR   PRIDE; P17209; -.
DR   RGD; 1591197; Myl4.
DR   eggNOG; KOG0030; Eukaryota.
DR   InParanoid; P17209; -.
DR   PhylomeDB; P17209; -.
DR   Reactome; R-RNO-390522; Striated Muscle Contraction.
DR   PRO; PR:P17209; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0031672; C:A band; ISO:RGD.
DR   GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; ISO:RGD.
DR   GO; GO:0003785; F:actin monomer binding; ISO:RGD.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0060048; P:cardiac muscle contraction; ISO:RGD.
DR   GO; GO:0032781; P:positive regulation of ATP-dependent activity; ISO:RGD.
DR   GO; GO:0002026; P:regulation of the force of heart contraction; ISO:RGD.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   2: Evidence at transcript level;
KW   Methylation; Motor protein; Muscle protein; Myosin; Reference proteome;
KW   Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:F1RRT2"
FT   CHAIN           2..193
FT                   /note="Myosin light chain 4"
FT                   /id="PRO_0000198701"
FT   DOMAIN          47..84
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          126..161
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          1..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N,N-dimethylproline"
FT                   /evidence="ECO:0000250|UniProtKB:F1RRT2"
SQ   SEQUENCE   193 AA;  21282 MW;  854A2B2C8B668253 CRC64;
     MPPKKPEPKK ETAKVAAAPA PAPAPAPEPL RDSAFDPKSV KIDFSADQIE EFKEAFSLFD
     RTPTGEMKIT YGQCGDVLRA LGQNPTNAEV LRVLGKPKPE EMNSKTLDFE MFLPILQHIS
     RNKEQGTYED FVEGLRVFDK ESNGTVMGAE LRHVLATLGE KMSEAEVEQL LTGQEDANGC
     INYEAFVKHV MSG