MYL5_FELCA
ID MYL5_FELCA Reviewed; 173 AA.
AC P41691; Q9BGM1;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2003, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Myosin light chain 5;
DE AltName: Full=Myosin regulatory light chain 5;
DE AltName: Full=Superfast myosin regulatory light chain 2;
DE Short=MYLC2;
DE Short=MyLC-2;
GN Name=MYL5;
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Masseter muscle;
RX PubMed=8185576; DOI=10.1006/bbrc.1994.1589;
RA Qin H., Morris B.J., Hoh J.F.Y.;
RT "Isolation and structure of cat superfast myosin light chain-2 cDNA and
RT evidence for the identity of its human homologue.";
RL Biochem. Biophys. Res. Commun. 200:1277-1282(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RA Hsu M.K.H., Hoh J.F.Y.;
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
CC -!- TISSUE SPECIFICITY: Jaw-closing muscles.
CC -!- MISCELLANEOUS: This chain binds calcium. {ECO:0000250}.
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DR EMBL; S70434; AAB30787.1; -; mRNA.
DR EMBL; AF229809; AAK00755.1; -; Genomic_DNA.
DR PIR; JC2242; JC2242.
DR RefSeq; NP_001009874.3; NM_001009874.3.
DR AlphaFoldDB; P41691; -.
DR SMR; P41691; -.
DR STRING; 9685.ENSFCAP00000015333; -.
DR Ensembl; ENSFCAT00000060819; ENSFCAP00000051253; ENSFCAG00000018168.
DR GeneID; 493974; -.
DR KEGG; fca:493974; -.
DR CTD; 4636; -.
DR VGNC; VGNC:68385; MYL5.
DR eggNOG; KOG0031; Eukaryota.
DR GeneTree; ENSGT00940000163023; -.
DR HOGENOM; CLU_061288_9_0_1; -.
DR InParanoid; P41691; -.
DR OrthoDB; 1435392at2759; -.
DR Proteomes; UP000011712; Chromosome B1.
DR Bgee; ENSFCAG00000018168; Expressed in adult mammalian kidney and 9 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF00036; EF-hand_1; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 2: Evidence at transcript level;
KW Calcium; Metal-binding; Motor protein; Muscle protein; Myosin;
KW Reference proteome; Repeat.
FT CHAIN 1..173
FT /note="Myosin light chain 5"
FT /id="PRO_0000198744"
FT DOMAIN 30..65
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 100..135
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 136..171
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 43
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 45
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 47
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 54
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT CONFLICT 127
FT /note="R -> P (in Ref. 1; AAB30787)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="Q -> H (in Ref. 1; AAB30787)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 173 AA; 19453 MW; 84B7AB0784F967AC CRC64;
MASRKTKKKE GGGLRAQRAS SNVFSNFEQT QIQEFKEAFT LMDQNRDGFI DKEDLKDTYA
SLGKTNIKDD ELDAMLKEAS GPINFTMFLN MFGAKLTGTD AEETILNAFK MLDPEGKGSI
NKDYIKRLLM SQADKMTAEE VDQMFQFATI DAAGNLDYKA LSYVLTHGEE KEE
