MYL6B_MOUSE
ID MYL6B_MOUSE Reviewed; 207 AA.
AC Q8CI43;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Myosin light chain 6B;
DE AltName: Full=Smooth muscle and nonmuscle myosin light chain alkali 6B;
GN Name=Myl6b {ECO:0000312|EMBL:AAH37527.1, ECO:0000312|MGI:MGI:1917789};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAH37527.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland {ECO:0000312|EMBL:AAH37527.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Regulatory light chain of myosin. Does not bind calcium.
CC {ECO:0000305}.
CC -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
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DR EMBL; BC037527; AAH37527.1; -; mRNA.
DR CCDS; CCDS24279.1; -.
DR RefSeq; NP_758463.1; NM_172259.1.
DR RefSeq; XP_017169402.1; XM_017313913.1.
DR RefSeq; XP_017169403.1; XM_017313914.1.
DR RefSeq; XP_017169404.1; XM_017313915.1.
DR RefSeq; XP_017169405.1; XM_017313916.1.
DR RefSeq; XP_017169406.1; XM_017313917.1.
DR AlphaFoldDB; Q8CI43; -.
DR SMR; Q8CI43; -.
DR BioGRID; 229752; 9.
DR IntAct; Q8CI43; 3.
DR MINT; Q8CI43; -.
DR STRING; 10090.ENSMUSP00000026428; -.
DR iPTMnet; Q8CI43; -.
DR PhosphoSitePlus; Q8CI43; -.
DR SwissPalm; Q8CI43; -.
DR EPD; Q8CI43; -.
DR jPOST; Q8CI43; -.
DR MaxQB; Q8CI43; -.
DR PaxDb; Q8CI43; -.
DR PeptideAtlas; Q8CI43; -.
DR PRIDE; Q8CI43; -.
DR ProteomicsDB; 286120; -.
DR Antibodypedia; 27985; 191 antibodies from 26 providers.
DR DNASU; 216459; -.
DR Ensembl; ENSMUST00000026428; ENSMUSP00000026428; ENSMUSG00000039824.
DR GeneID; 216459; -.
DR KEGG; mmu:216459; -.
DR UCSC; uc007hne.1; mouse.
DR CTD; 140465; -.
DR MGI; MGI:1917789; Myl6b.
DR VEuPathDB; HostDB:ENSMUSG00000039824; -.
DR eggNOG; KOG0030; Eukaryota.
DR GeneTree; ENSGT01030000234570; -.
DR HOGENOM; CLU_061288_13_0_1; -.
DR InParanoid; Q8CI43; -.
DR OMA; DIRYMLT; -.
DR OrthoDB; 1470794at2759; -.
DR PhylomeDB; Q8CI43; -.
DR TreeFam; TF351553; -.
DR Reactome; R-MMU-445355; Smooth Muscle Contraction.
DR BioGRID-ORCS; 216459; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Myl6b; mouse.
DR PRO; PR:Q8CI43; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8CI43; protein.
DR Bgee; ENSMUSG00000039824; Expressed in cortical plate and 72 other tissues.
DR GO; GO:0016459; C:myosin complex; TAS:HGNC-UCL.
DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR GO; GO:0016461; C:unconventional myosin complex; TAS:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0003774; F:cytoskeletal motor activity; TAS:HGNC-UCL.
DR GO; GO:0008307; F:structural constituent of muscle; IBA:GO_Central.
DR GO; GO:0006936; P:muscle contraction; TAS:HGNC-UCL.
DR GO; GO:0030049; P:muscle filament sliding; TAS:HGNC-UCL.
DR GO; GO:0007519; P:skeletal muscle tissue development; TAS:HGNC-UCL.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 1: Evidence at protein level;
KW Motor protein; Muscle protein; Myosin; Reference proteome; Repeat.
FT CHAIN 1..207
FT /note="Myosin light chain 6B"
FT /id="PRO_0000248833"
FT DOMAIN 63..98
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 140..175
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 175..207
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 207 AA; 22749 MW; F402A5302A44F708 CRC64;
MPPKKDAPVK KPAGPSISKP AAKSTPGTPL AKAKAEPAAP QAPAKSQEPP VDLSKVVIEF
NKDQLEEFRE AFELFDRVGD GKILYSQCGD LMRALGQNPT NAEVLKVLGN PKNEELKSRR
VDFETFLPML QAVAKNRDQG TYEDYLEGLR VFDKEGNGKV MGAELRHVLT TLGEKMTEEE
VETVLAGHED SNGCINYEAF LKHILSL
