MYL6_BOVIN
ID MYL6_BOVIN Reviewed; 151 AA.
AC P60661; A5PJX9; P16475; P24572; P24573; Q12790; Q3SYR6;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Myosin light polypeptide 6;
DE AltName: Full=17 kDa myosin light chain;
DE Short=LC17;
DE AltName: Full=Myosin light chain 3;
DE Short=MLC-3;
DE AltName: Full=Myosin light chain alkali 3;
DE Short=Myosin light chain A3;
GN Name=MYL6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS NON-MUSCLE AND SMOOTH MUSCLE).
RC TISSUE=Aorta;
RX PubMed=2263497; DOI=10.1093/nar/18.23.7176;
RA Lash J.A., Helper D.J., Klug M., Nicolozakes A.W., Hathaway D.R.;
RT "Nucleotide and deduced amino acid sequence of cDNAs encoding two isoforms
RT for the 17,000 dalton myosin light chain in bovine aortic smooth muscle.";
RL Nucleic Acids Res. 18:7176-7176(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS NON-MUSCLE AND SMOOTH
RP MUSCLE).
RC STRAIN=Hereford; TISSUE=Fetal spinal cord, and Testis;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Regulatory light chain of myosin. Does not bind calcium.
CC -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
CC Interacts with SPATA6. {ECO:0000250|UniProtKB:Q60605}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Non-muscle; Synonyms=MLC3nm, LC17A, LC17-nm;
CC IsoId=P60661-1, P16475-1;
CC Sequence=Displayed;
CC Name=Smooth muscle; Synonyms=MLC3sm, LC17B, LC17-sm;
CC IsoId=P60661-2, P24572-1;
CC Sequence=VSP_009734;
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DR EMBL; X54977; CAA38721.1; -; mRNA.
DR EMBL; X54978; CAA38722.1; -; mRNA.
DR EMBL; BC103428; AAI03429.1; -; mRNA.
DR EMBL; BC142278; AAI42279.1; -; mRNA.
DR PIR; S13671; S13671.
DR PIR; S13672; S13672.
DR RefSeq; NP_786974.1; NM_175780.1. [P60661-1]
DR RefSeq; XP_005206559.1; XM_005206502.3. [P60661-2]
DR AlphaFoldDB; P60661; -.
DR SMR; P60661; -.
DR STRING; 9913.ENSBTAP00000014304; -.
DR PaxDb; P60661; -.
DR PeptideAtlas; P60661; -.
DR PRIDE; P60661; -.
DR Ensembl; ENSBTAT00000014304; ENSBTAP00000014304; ENSBTAG00000010799. [P60661-1]
DR GeneID; 281341; -.
DR KEGG; bta:281341; -.
DR CTD; 4637; -.
DR VEuPathDB; HostDB:ENSBTAG00000010799; -.
DR eggNOG; KOG0030; Eukaryota.
DR GeneTree; ENSGT01030000234570; -.
DR HOGENOM; CLU_061288_13_0_1; -.
DR InParanoid; P60661; -.
DR OMA; PANEHRN; -.
DR OrthoDB; 1470794at2759; -.
DR TreeFam; TF351553; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000010799; Expressed in aorta and 105 other tissues.
DR ExpressionAtlas; P60661; baseline and differential.
DR GO; GO:0005903; C:brush border; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0000146; F:microfilament motor activity; ISS:HGNC-UCL.
DR GO; GO:0008307; F:structural constituent of muscle; ISS:HGNC-UCL.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Motor protein; Muscle protein; Myosin;
KW Phosphoprotein; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P60660"
FT CHAIN 2..151
FT /note="Myosin light polypeptide 6"
FT /id="PRO_0000198689"
FT DOMAIN 7..42
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 84..119
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT MOD_RES 2
FT /note="N-acetylcysteine"
FT /evidence="ECO:0000250|UniProtKB:P60660"
FT MOD_RES 57
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P60660"
FT MOD_RES 81
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P60660"
FT VAR_SEQ 143..151
FT /note="AFVRHILSG -> ELVRMVLNG (in isoform Smooth muscle)"
FT /evidence="ECO:0000303|PubMed:2263497, ECO:0000303|Ref.2"
FT /id="VSP_009734"
SQ SEQUENCE 151 AA; 16930 MW; A2B7B4F41179523D CRC64;
MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK VLGNPKSDEM
NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG NGTVMGAEIR HVLVTLGEKM
TEEEVEMLVA GHEDSNGCIN YEAFVRHILS G
